High Incidence of Potential p53 Inactivation in Poor Outcome Childhood Acute Lymphoblastic Leukemia at Diagnosis

Previous studies have indicated that p53 gene mutations were an uncommon event in acute lymphoblastic leukemia (ALL) in children. In one series of 330 patients, p53 mutations were seen in fewer than 3%. We analyzed bone marrow mononuclear cells derived from 10 children with ALL at diagnosis who subs...

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