Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

Binding of α factor to Ste2p, a G protein–coupled plasma membrane receptor, activates a signal transduction pathway and stimulates endocytosis of the receptor–ligand complex. Ligand binding also induces ubiquitination of the Ste2p cytoplasmic tail. Protein ubiquitination is required for stimulated e...

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