Malignant glomus tumor : a case report of widespread metastases in a patient with multiple glomus body hamartomas
Glomus tumors are characteristically benign solitary tumors. A few cases of malignant glomus tumors have been reported; however, they are usually only locally invasive, and metastases are exceedingly rare. We report a case of widespread metastases of a malignant glomus tumor involving the skin, lung...
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| Veröffentlicht in: | The American journal of surgical pathology 1996-02, Vol.20 (2), p.233-238 |
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| creator | BRATHWAITE, C. D POPPITI, R. J |
| description | Glomus tumors are characteristically benign solitary tumors. A few cases of malignant glomus tumors have been reported; however, they are usually only locally invasive, and metastases are exceedingly rare. We report a case of widespread metastases of a malignant glomus tumor involving the skin, lungs, jejunum, liver, spleen, and lymph nodes in a 63-year-old man with end-stage chronic renal failure. At autopsy, multiple glomus body hamartomas were also noted throughout the dermis proximal to the skin tumors. Histologically, the tumor was composed of monotonous round cells in solid sheets and investing numerous capillary-sized vessels. Approximately four to six mitoses were present per high-power field. The tumor cells were strongly immunoreactive for actin and vimentin, and ultrastructurally there were whorls of microfilaments with focal condensations. This case is exceptional because of its aggressive course. |
| doi_str_mv | 10.1097/00000478-199602000-00012 |
| format | Article |
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D ; POPPITI, R. J</creator><creatorcontrib>BRATHWAITE, C. D ; POPPITI, R. J</creatorcontrib><description>Glomus tumors are characteristically benign solitary tumors. A few cases of malignant glomus tumors have been reported; however, they are usually only locally invasive, and metastases are exceedingly rare. We report a case of widespread metastases of a malignant glomus tumor involving the skin, lungs, jejunum, liver, spleen, and lymph nodes in a 63-year-old man with end-stage chronic renal failure. At autopsy, multiple glomus body hamartomas were also noted throughout the dermis proximal to the skin tumors. Histologically, the tumor was composed of monotonous round cells in solid sheets and investing numerous capillary-sized vessels. Approximately four to six mitoses were present per high-power field. The tumor cells were strongly immunoreactive for actin and vimentin, and ultrastructurally there were whorls of microfilaments with focal condensations. This case is exceptional because of its aggressive course.</description><identifier>ISSN: 0147-5185</identifier><identifier>EISSN: 1532-0979</identifier><identifier>DOI: 10.1097/00000478-199602000-00012</identifier><identifier>PMID: 8554113</identifier><identifier>CODEN: AJSPDX</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Antigens, Neoplasm - analysis ; Biological and medical sciences ; Cytoskeletal Proteins - analysis ; Dermatology ; Glomus Tumor - chemistry ; Glomus Tumor - pathology ; Hamartoma - pathology ; Humans ; Immunoenzyme Techniques ; Kidney Failure, Chronic - complications ; Male ; Medical sciences ; Middle Aged ; Mucin-1 - analysis ; Neoplasm Metastasis ; S100 Proteins - analysis ; Skin Neoplasms - chemistry ; Skin Neoplasms - pathology ; Tumors of the skin and soft tissue. 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J</creatorcontrib><title>Malignant glomus tumor : a case report of widespread metastases in a patient with multiple glomus body hamartomas</title><title>The American journal of surgical pathology</title><addtitle>Am J Surg Pathol</addtitle><description>Glomus tumors are characteristically benign solitary tumors. A few cases of malignant glomus tumors have been reported; however, they are usually only locally invasive, and metastases are exceedingly rare. We report a case of widespread metastases of a malignant glomus tumor involving the skin, lungs, jejunum, liver, spleen, and lymph nodes in a 63-year-old man with end-stage chronic renal failure. At autopsy, multiple glomus body hamartomas were also noted throughout the dermis proximal to the skin tumors. Histologically, the tumor was composed of monotonous round cells in solid sheets and investing numerous capillary-sized vessels. Approximately four to six mitoses were present per high-power field. The tumor cells were strongly immunoreactive for actin and vimentin, and ultrastructurally there were whorls of microfilaments with focal condensations. This case is exceptional because of its aggressive course.</description><subject>Antigens, Neoplasm - analysis</subject><subject>Biological and medical sciences</subject><subject>Cytoskeletal Proteins - analysis</subject><subject>Dermatology</subject><subject>Glomus Tumor - chemistry</subject><subject>Glomus Tumor - pathology</subject><subject>Hamartoma - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mucin-1 - analysis</subject><subject>Neoplasm Metastasis</subject><subject>S100 Proteins - analysis</subject><subject>Skin Neoplasms - chemistry</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0147-5185</issn><issn>1532-0979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1P3DAQhq2KChban1DJB8QtrT-Stc0NIdoiUfXSnqOxMwZXSRxsR2j_fb2w7MjWjDXPvGO9hFDOvnJm1De2j1bphhuzZaI-mnq5-EA2vJOiqYw5IRvGW9V0XHdn5Dznf3tCc3FKTnXXtZzLDXn-BWN4nGEu9HGM05ppWaeY6DUF6iAjTbjEVGj09CUMmJeEMNAJC-R6MNMwV3KBErBKvITyRKd1LGEZ8V3QxmFHn2CCVOIE-RP56GHM-PmQL8jf73d_bn82D79_3N_ePDRO6LY0FqSU2urBgTVMe98hSkBvud0OUAO34Fz7WrmWWSVb740BNgjU2lt5Qa7edJcUn1fMpZ9CdjiOMGNcc6-UUZwLVUH9BroUc07o-yWF-ttdz1m_d7t_d7s_ut2_ul1Hvxx2rHbC4Th4sLf2Lw99yA5Gn2B2IR8xYdS2E0z-B1wUizY</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>BRATHWAITE, C. D</creator><creator>POPPITI, R. 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Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRATHWAITE, C. D</creatorcontrib><creatorcontrib>POPPITI, R. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BRATHWAITE, C. D</au><au>POPPITI, R. 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At autopsy, multiple glomus body hamartomas were also noted throughout the dermis proximal to the skin tumors. Histologically, the tumor was composed of monotonous round cells in solid sheets and investing numerous capillary-sized vessels. Approximately four to six mitoses were present per high-power field. The tumor cells were strongly immunoreactive for actin and vimentin, and ultrastructurally there were whorls of microfilaments with focal condensations. This case is exceptional because of its aggressive course.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>8554113</pmid><doi>10.1097/00000478-199602000-00012</doi><tpages>6</tpages></addata></record> |
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| ispartof | The American journal of surgical pathology, 1996-02, Vol.20 (2), p.233-238 |
| issn | 0147-5185 1532-0979 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Antigens, Neoplasm - analysis Biological and medical sciences Cytoskeletal Proteins - analysis Dermatology Glomus Tumor - chemistry Glomus Tumor - pathology Hamartoma - pathology Humans Immunoenzyme Techniques Kidney Failure, Chronic - complications Male Medical sciences Middle Aged Mucin-1 - analysis Neoplasm Metastasis S100 Proteins - analysis Skin Neoplasms - chemistry Skin Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions |
| title | Malignant glomus tumor : a case report of widespread metastases in a patient with multiple glomus body hamartomas |
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