Comparison of the segregation of the RYR1/C1840T mutation with segregation of the caffeine/halothane contracture test results for malignant hyperthermia susceptibility in a large Manitoba Mennonite family

Malignant hyperthermia (MH) is an important cause of anesthesia-induced death. Malignant hyperthermia susceptibility is diagnosed using the in vitro caffeine/halothane contracture test (CHCT) in fresh muscle biopsy specimens. The CHCT test is highly invasive, expensive, and lacks 100% specificity. G...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1996-02, Vol.84 (2), p.322-329
Hauptverfasser:	SERFAS, K. D, BOSE, D, PATEL, L, WROGEMANN, K, PHILLIPS, M. S, MACLENNAN, D. H, GREENBERG, C. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation Biological and medical sciences Caffeine Disease Susceptibility Female General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Halothane Heterozygote Humans Male Malignant Hyperthermia - diagnosis Malignant Hyperthermia - genetics Manitoba Medical sciences Middle Aged Muscle Contraction - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Mutation Pedigree
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