Population Dynamics of Immune Responses to Persistent Viruses

Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relati...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1996-04, Vol.272 (5258), p.74-79
Hauptverfasser:	Nowak, Martin A., Charles R. M. Bangham
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS AIDS/HIV Antibodies, Viral - immunology Antigenic Variation Antigens, Viral - immunology Cytokines - immunology Cytotoxicity, Immunologic Drug Therapy Epitopes Epitopes - immunology Feedback (Response) Genetic Variation HIV HIV Infections - immunology HIV Infections - virology HIV-1 - immunology HIV-1 - physiology HTLV-I Infections - immunology HTLV-I Infections - virology Human immunodeficiency virus Human immunodeficiency virus 1 Human T lymphotropic virus 1 Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - immunology Human T-lymphotropic virus 1 - physiology Humans Immune response Immune response regulation Immunity (Disease) Immunology Infections Leukemia Mathematical models Models, Biological Mutation Population Dynamics Regulation Reproduction T-Lymphocytes, Cytotoxic - immunology Transponders Viral research Virus Diseases - immunology Virus Diseases - virology Virus Physiological Phenomena Virus Replication Virus research Viruses Viruses - genetics Viruses - immunology
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Beschreibung
Zusammenfassung:	Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on cytotoxic T cell responses and viral diversity in infections with the human T cell leukemia virus (HTLV-1) and the human immunodeficiency virus (HIV-1).
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.272.5258.74