Dual action of tirapazamine in the induction of DNA strand breaks

Tirapazamine (3-amino-1,2,4-benzotriazine-1,4-dioxide, SR 4233) is the lead compound of a new class of hypoxic cell cytotoxins showing considerable antitumor activity. Hypoxic cytotoxicity of tirapazamine is believed to be mediated by free radical attack of its one-electron reduced metabolite on DNA...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1996-04, Vol.56 (7), p.1584-1590
Hauptverfasser:	JONES, G. D. D, WEINFELD, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences DNA - drug effects DNA Damage General aspects Glycolates - metabolism Medical sciences Pharmacology. Drug treatments Radiation-Sensitizing Agents - pharmacology Triazines - pharmacology
Online-Zugang:	Volltext
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