Metabolic Deglucuronidation and Demethylation of Estrogen Conjugates as a Source of Parent Estrogens and Catecholestrogen Metabolites in Syrian Hamster Kidney, a Target Organ of Estrogen-Induced Tumorigenesis

Estrogen-induced tumors in kidneys of male Syrian hamsters have been postulated to arise from cells which are damaged by free radicals and other reactive species generated during metabolic redox cycling of catecholestrogens and which at the same time are exposed to excessive growth stimulation media...

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