Dual Metalloprotease Inhibitors. 6. Incorporation of Bicyclic and Substituted Monocyclic Azepinones as Dipeptide Surrogates in Angiotensin-Converting Enzyme/Neutral Endopeptidase Inhibitors

A series of substituted monocyclic and bicyclic azepinones were incorporated as dipeptide surrogates in mercaptoacetyl dipeptides with the desire to generate a single compound which would potently inhibit both angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). Many of these compoun...

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Veröffentlicht in:	Journal of medicinal chemistry 1996-01, Vol.39 (2), p.494-502
Hauptverfasser:	Robl, Jeffrey A, Cimarusti, Maria P, Simpkins, Ligaya M, Brown, Baerbel, Ryono, Denis E, Bird, J. Eileen, Asaad, Magdi M, Schaeffer, Thomas R, Trippodo, Nick C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive Agents - pharmacology Azepines - pharmacology Dipeptides - pharmacology Kidney - enzymology Lung - enzymology Male Metalloendopeptidases - antagonists & inhibitors Molecular Sequence Data Neprilysin - antagonists & inhibitors Protease Inhibitors - pharmacology Rats Rats, Sprague-Dawley
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