In vivo antitumor activity of cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) formulated in long-circulating liposomes

A lipophilic cisplatin derivative, cis-bis-neodecanoato-trans- R,R-1,2-diaminocyclohexane platinum (II) (NDDP), was formulated in liposomes composed of phosphatidylcholine (PC) and cholesterol (Chol) additionally containing monosialoganglioside (Gm1) or polyethyleneglycol conjugated to phosphatidyle...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1996, Vol.37 (5), p.435-444
Hauptverfasser:	MORI, A, SU-PING WU, HAN, I, KHOKHAR, A. R, PEREZ-SOLER, R, LEAF HUANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Cell Survival - drug effects Chemotherapy Cholesterol Drug Carriers Female Fibrosarcoma - drug therapy Fibrosarcoma - metabolism Fibrosarcoma - pathology G(M1) Ganglioside Liposomes Medical sciences Mice Mice, Inbred C3H Neoplasm Transplantation Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - pharmacokinetics Organoplatinum Compounds - pharmacology Organoplatinum Compounds - therapeutic use Pharmacology. Drug treatments Phosphatidylcholines Phosphatidylethanolamines Platinum - analysis Polyethylene Glycols Solubility Time Factors Tissue Distribution
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