Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA

Variants of λ repressor and cytochrome b$_{562}$ translated from messenger RNAs without stop codons were modified by carboxyl terminal addition of an ssrA-encoded peptide tag and subsequently degraded by carboxyl terminal-specific proteases present in both the cytoplasm and periplasm of Escherichia...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1996-02, Vol.271 (5251), p.990-993
Hauptverfasser:	Keiler, Kenneth C., Patrick R. H. Waller, Sauer, Robert T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino Acid Sequence Base Sequence Biological and medical sciences Cloning, Molecular Codon, Terminator Cytochrome b Group - genetics Cytochrome b Group - metabolism Cytochromes DNA-Binding Proteins Endopeptidases - metabolism Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins Fundamental and applied biological sciences. Psychology Genes Half lives Mass spectroscopy Messenger RNA Molecular and cellular biology Molecular genetics Molecular Sequence Data Peptides Peptides - metabolism phage lambda Protein Biosynthesis Protein Processing, Post-Translational Proteins Repressor Proteins - genetics Repressor Proteins - metabolism Ribonucleic acid Ribosomes RNA RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Stop codon Terminator regions Transcription. Transcription factor. Splicing. Rna processing Translation Viral Proteins Viral Regulatory and Accessory Proteins
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