2-[ 125I]Iodomelatonin binding sites in the quail heart: Characteristics, distribution and modulation by guanine nucleotides and cations

To investigate whether melatonin has a direct action on the cardiovascular system, putative melatonin receptors were studied in quail heart membrane preparations using the specific melatonin agonist 2-[ 125I]iodomelatonin ([ 125I]Mel) as the radioligand. The [ 125I]Mel binding demonstrated in the ma...

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Veröffentlicht in:	Life sciences (1973) 1996, Vol.58 (13), p.1047-1057
Hauptverfasser:	Pang, C.S., Tang, P.L., Song, Y., Brown, G.M., Panga, S.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Binding Sites Binding, Competitive calcium Calcium Chloride - pharmacology Cell Membrane - metabolism Choline - pharmacology Coturnix Female guanine nucleotide Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Iodine Radioisotopes Kinetics magnesium Magnesium Chloride - pharmacology Male Melatonin - analogs & derivatives Melatonin - metabolism Melatonin - pharmacology melatonin receptor Myocardium - cytology Myocardium - metabolism pineal gland potassium Radioligand Assay Receptors, Cell Surface - analysis Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Melatonin Sensitivity and Specificity sodium Structure-Activity Relationship
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