Age-Related Dynamics of Cognitive Brain Functions in Humans: An Electrophysiological Approach
Event-related P300 potentials closely reflect cognitive functions such as stimulus discrimination (N250) and processing time (P300 latencies) as well as attention capabilities (P300 amplitudes). To delineate the age-related dynamics of P300 potentials, we investigated 250 healthy subjects between 18...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 1996-01, Vol.51A (1), p.B3-B16 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Kügler, Christian F. A. Petter, Jürgen Platt, Dieter |
| description | Event-related P300 potentials closely reflect cognitive functions such as stimulus discrimination (N250) and processing time (P300 latencies) as well as attention capabilities (P300 amplitudes). To delineate the age-related dynamics of P300 potentials, we investigated 250 healthy subjects between 18 and 98 years of age in a cross-sectional study. A total of 330 visual P300 tests was performed in two different paradigms (PI, passive condition, n = 80; PII, active condition, n = 250). In both P300 paradigms, the N250 and P300 latencies were markedly prolonged (p < .0001) in older age, whereas the N250 and P300 latency differences between PII and PI did not change (p > .05). The P300 amplitudes in paradigm I and II revealed only a slight age-related reduction. In fact, the P300 amplitude ratios between PII and PI remained constant. Third-order polynomial regressions provided the best fit of the aging-P300 interactions in paradigms I and II for both males and females. Interestingly, females showed a greater and possibly earlier P300 latency increase during aging than males. These age-related changes of P300 potentials indicate a rather mild cognitive decline that does not accelerate before old age and may be different between both sexes. |
| doi_str_mv | 10.1093/gerona/51A.1.B3 |
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A. ; Petter, Jürgen ; Platt, Dieter</creator><creatorcontrib>Kügler, Christian F. A. ; Petter, Jürgen ; Platt, Dieter</creatorcontrib><description>Event-related P300 potentials closely reflect cognitive functions such as stimulus discrimination (N250) and processing time (P300 latencies) as well as attention capabilities (P300 amplitudes). To delineate the age-related dynamics of P300 potentials, we investigated 250 healthy subjects between 18 and 98 years of age in a cross-sectional study. A total of 330 visual P300 tests was performed in two different paradigms (PI, passive condition, n = 80; PII, active condition, n = 250). In both P300 paradigms, the N250 and P300 latencies were markedly prolonged (p < .0001) in older age, whereas the N250 and P300 latency differences between PII and PI did not change (p > .05). The P300 amplitudes in paradigm I and II revealed only a slight age-related reduction. In fact, the P300 amplitude ratios between PII and PI remained constant. Third-order polynomial regressions provided the best fit of the aging-P300 interactions in paradigms I and II for both males and females. Interestingly, females showed a greater and possibly earlier P300 latency increase during aging than males. These age-related changes of P300 potentials indicate a rather mild cognitive decline that does not accelerate before old age and may be different between both sexes.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/51A.1.B3</identifier><identifier>PMID: 8548496</identifier><language>eng</language><publisher>United States: The Gerontological Society of America</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging ; Aging - physiology ; Brain ; Brain - physiology ; Cognition & reasoning ; Cognition - physiology ; Cross-Sectional Studies ; Evoked Potentials, Visual ; Female ; Humans ; Male ; Middle Aged ; Regression Analysis</subject><ispartof>The journals of gerontology. 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A.</creatorcontrib><creatorcontrib>Petter, Jürgen</creatorcontrib><creatorcontrib>Platt, Dieter</creatorcontrib><title>Age-Related Dynamics of Cognitive Brain Functions in Humans: An Electrophysiological Approach</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Event-related P300 potentials closely reflect cognitive functions such as stimulus discrimination (N250) and processing time (P300 latencies) as well as attention capabilities (P300 amplitudes). To delineate the age-related dynamics of P300 potentials, we investigated 250 healthy subjects between 18 and 98 years of age in a cross-sectional study. A total of 330 visual P300 tests was performed in two different paradigms (PI, passive condition, n = 80; PII, active condition, n = 250). In both P300 paradigms, the N250 and P300 latencies were markedly prolonged (p < .0001) in older age, whereas the N250 and P300 latency differences between PII and PI did not change (p > .05). The P300 amplitudes in paradigm I and II revealed only a slight age-related reduction. In fact, the P300 amplitude ratios between PII and PI remained constant. Third-order polynomial regressions provided the best fit of the aging-P300 interactions in paradigms I and II for both males and females. Interestingly, females showed a greater and possibly earlier P300 latency increase during aging than males. These age-related changes of P300 potentials indicate a rather mild cognitive decline that does not accelerate before old age and may be different between both sexes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Brain</subject><subject>Brain - physiology</subject><subject>Cognition & reasoning</subject><subject>Cognition - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Evoked Potentials, Visual</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Regression Analysis</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNp1kc1rGzEQxUVoSVIn554KooHe1tbHSlr1tnaSOhCSUAINhSJkWeso2ZUcabfU_33l2uQQ6CCYEe_HG4kHwEeMxhhJOlnZGLyeMFyP8XhKD8AxFqwqGGUP7_KMhCwYQvwIfEjpCW2LkUNwWLGyKiU_Br_qlS2-21b3dgnPN153ziQYGjgLK-9699vCadTOw8vBm94Fn2C-zIdO-_QV1h5etNb0MawfN8mFNqyc0S2s1-sYtHk8Ae8b3SZ7uu8jcH95cT-bF9e3365m9XVhSsL7giJZmgVnzC4FN03ZLDCxpZTYiPwBIozhxogGCcEIqXgjkcQUN5UUGZaSjsCXnW3e-jLY1KvOJWPbVnsbhqSEkFxU_8DPb8CnMESfn6YIqjgpOaEZOvsfhCshMGU0nxGY7CgTQ0rRNmodXafjRmGkttGoXTQqR6Owmm59P-19h0Vnl6_8PousFzvdpd7-eZV1fFZcUMHU_OGnwjf4B75DUjH6F6s8mIA</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>Kügler, Christian F. A.</creator><creator>Petter, Jürgen</creator><creator>Platt, Dieter</creator><general>The Gerontological Society of America</general><general>Gerontological Society of America</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOIBA</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>199601</creationdate><title>Age-Related Dynamics of Cognitive Brain Functions in Humans: An Electrophysiological Approach</title><author>Kügler, Christian F. 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Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kügler, Christian F. A.</au><au>Petter, Jürgen</au><au>Platt, Dieter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-Related Dynamics of Cognitive Brain Functions in Humans: An Electrophysiological Approach</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>1996-01</date><risdate>1996</risdate><volume>51A</volume><issue>1</issue><spage>B3</spage><epage>B16</epage><pages>B3-B16</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Event-related P300 potentials closely reflect cognitive functions such as stimulus discrimination (N250) and processing time (P300 latencies) as well as attention capabilities (P300 amplitudes). To delineate the age-related dynamics of P300 potentials, we investigated 250 healthy subjects between 18 and 98 years of age in a cross-sectional study. A total of 330 visual P300 tests was performed in two different paradigms (PI, passive condition, n = 80; PII, active condition, n = 250). In both P300 paradigms, the N250 and P300 latencies were markedly prolonged (p < .0001) in older age, whereas the N250 and P300 latency differences between PII and PI did not change (p > .05). The P300 amplitudes in paradigm I and II revealed only a slight age-related reduction. In fact, the P300 amplitude ratios between PII and PI remained constant. Third-order polynomial regressions provided the best fit of the aging-P300 interactions in paradigms I and II for both males and females. Interestingly, females showed a greater and possibly earlier P300 latency increase during aging than males. These age-related changes of P300 potentials indicate a rather mild cognitive decline that does not accelerate before old age and may be different between both sexes.</abstract><cop>United States</cop><pub>The Gerontological Society of America</pub><pmid>8548496</pmid><doi>10.1093/gerona/51A.1.B3</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 1996-01, Vol.51A (1), p.B3-B16 |
| issn | 1079-5006 1758-535X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77967899 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Periodicals Index Online |
| subjects | Adolescent Adult Aged Aged, 80 and over Aging Aging - physiology Brain Brain - physiology Cognition & reasoning Cognition - physiology Cross-Sectional Studies Evoked Potentials, Visual Female Humans Male Middle Aged Regression Analysis |
| title | Age-Related Dynamics of Cognitive Brain Functions in Humans: An Electrophysiological Approach |
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