Correlates of Tumor Size, Gender, Cell Type, and Metastasis of Resected Non-Small Cell Lung Cancer and Age
The purpose of this retrospective study was to examine the relationship between tumor volume and age in resected nonsmall cell lung cancer (NSCLC). Differences exist in the behavior, growth rate, and metastatic potential of solid tumors in both aged humans and experimental animal models. Data from 6...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 1996-01, Vol.51A (1), p.B50-B53 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Pendleton, N. Jefferson, M.F. Dixon, G.R. Myskow, M.W. Horan, M.A. |
| description | The purpose of this retrospective study was to examine the relationship between tumor volume and age in resected nonsmall cell lung cancer (NSCLC). Differences exist in the behavior, growth rate, and metastatic potential of solid tumors in both aged humans and experimental animal models. Data from 669 cases of NSCLC resected between 1980 and 1992 were reviewed (445 males; 224 females; median age 67 years, range 16–86). Measurements of the resected tumor in-situ were made in three dimensions, and these were multiplied to give an estimate of the tumor volume. Multiple regression analysis was used to examine the relationship between the tumor volume, age, gender, histological cell type, and TNM nodal score. No direct relationship existed between patient age and tumor volume or nodal score. However, there was a significant relationship between patient gender and tumor volume, i.e., smaller volume tumors in female patients (p = .02). Considering all variables, two relational subgroups were identified: younger male patients with large adenocarcinomas and older female patients with small squamous cell carcinomas (p = .05). We conclude that the relationship between tumor volume and age is complex and dependent on patient gender and tumor cell type. |
| doi_str_mv | 10.1093/gerona/51A.1.B50 |
| format | Article |
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Differences exist in the behavior, growth rate, and metastatic potential of solid tumors in both aged humans and experimental animal models. Data from 669 cases of NSCLC resected between 1980 and 1992 were reviewed (445 males; 224 females; median age 67 years, range 16–86). Measurements of the resected tumor in-situ were made in three dimensions, and these were multiplied to give an estimate of the tumor volume. Multiple regression analysis was used to examine the relationship between the tumor volume, age, gender, histological cell type, and TNM nodal score. No direct relationship existed between patient age and tumor volume or nodal score. However, there was a significant relationship between patient gender and tumor volume, i.e., smaller volume tumors in female patients (p = .02). Considering all variables, two relational subgroups were identified: younger male patients with large adenocarcinomas and older female patients with small squamous cell carcinomas (p = .05). We conclude that the relationship between tumor volume and age is complex and dependent on patient gender and tumor cell type.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/51A.1.B50</identifier><identifier>PMID: 8548500</identifier><language>eng</language><publisher>United States: The Gerontological Society of America</publisher><subject>Adenocarcinoma - pathology ; Adolescent ; Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Carcinoid Tumor - pathology ; Carcinoma, Large Cell - pathology ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Squamous Cell - pathology ; Cellular biology ; Female ; Humans ; Lung cancer ; Lung Neoplasms - pathology ; Male ; Middle Aged ; Neoplasm Metastasis ; Retrospective Studies ; Sex Factors ; Sexes ; Tumors</subject><ispartof>The journals of gerontology. 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Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>The purpose of this retrospective study was to examine the relationship between tumor volume and age in resected nonsmall cell lung cancer (NSCLC). Differences exist in the behavior, growth rate, and metastatic potential of solid tumors in both aged humans and experimental animal models. Data from 669 cases of NSCLC resected between 1980 and 1992 were reviewed (445 males; 224 females; median age 67 years, range 16–86). Measurements of the resected tumor in-situ were made in three dimensions, and these were multiplied to give an estimate of the tumor volume. Multiple regression analysis was used to examine the relationship between the tumor volume, age, gender, histological cell type, and TNM nodal score. No direct relationship existed between patient age and tumor volume or nodal score. However, there was a significant relationship between patient gender and tumor volume, i.e., smaller volume tumors in female patients (p = .02). Considering all variables, two relational subgroups were identified: younger male patients with large adenocarcinomas and older female patients with small squamous cell carcinomas (p = .05). We conclude that the relationship between tumor volume and age is complex and dependent on patient gender and tumor cell type.</description><subject>Adenocarcinoma - pathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoid Tumor - pathology</subject><subject>Carcinoma, Large Cell - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cellular biology</subject><subject>Female</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Sexes</subject><subject>Tumors</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNp1kUtrGzEUhUVoSfPad1MQLWSVcaSR9ZilO7ROwU4gcULIRsiaKzOuZ-RKM9Dk10d-kEUgQqDLvd85unAQ-krJgJKCXS4g-NZccjoa0MFPTg7QEZVcZZzxx0-pJrLIOCHiCzqOcUk2h-eH6FDxoUr9I7QsfQiwMh1E7B2e9Y0P-K5-gQs8hraCcIFLWK3w7HmdWqat8BQ6E9Ott4JbiGA7qPC1b7O7xiR0y0_6doFL01oIW9VoAafoszOrCGf79wTd__41K6-yyc34TzmaZHaYF12mGDXOCpfPeU5ZJaTlnBXcOSgIU04wOSfOVFbMK7BAhRtSw5XIAcBSRQU7Qec733Xw_3qInW7qaNNSpgXfRy1lIUShVAK_vwOXvg9t2k3nJDlSLniCfnwEUSUlpQURmz_JjrLBxxjA6XWoGxOeNSV6k5TeJaVTUprqlFSSfNsb9_MGqjfBPpo0z3bzOnbw_21swl8tJJNcXz0-aS6extOHyVRL9gqUdJ1v</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>Pendleton, N.</creator><creator>Jefferson, M.F.</creator><creator>Dixon, G.R.</creator><creator>Myskow, M.W.</creator><creator>Horan, M.A.</creator><general>The Gerontological Society of America</general><general>Gerontological Society of America</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOIBA</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>199601</creationdate><title>Correlates of Tumor Size, Gender, Cell Type, and Metastasis of Resected Non-Small Cell Lung Cancer and Age</title><author>Pendleton, N. ; 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Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pendleton, N.</au><au>Jefferson, M.F.</au><au>Dixon, G.R.</au><au>Myskow, M.W.</au><au>Horan, M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlates of Tumor Size, Gender, Cell Type, and Metastasis of Resected Non-Small Cell Lung Cancer and Age</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>1996-01</date><risdate>1996</risdate><volume>51A</volume><issue>1</issue><spage>B50</spage><epage>B53</epage><pages>B50-B53</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>The purpose of this retrospective study was to examine the relationship between tumor volume and age in resected nonsmall cell lung cancer (NSCLC). Differences exist in the behavior, growth rate, and metastatic potential of solid tumors in both aged humans and experimental animal models. Data from 669 cases of NSCLC resected between 1980 and 1992 were reviewed (445 males; 224 females; median age 67 years, range 16–86). Measurements of the resected tumor in-situ were made in three dimensions, and these were multiplied to give an estimate of the tumor volume. Multiple regression analysis was used to examine the relationship between the tumor volume, age, gender, histological cell type, and TNM nodal score. No direct relationship existed between patient age and tumor volume or nodal score. However, there was a significant relationship between patient gender and tumor volume, i.e., smaller volume tumors in female patients (p = .02). Considering all variables, two relational subgroups were identified: younger male patients with large adenocarcinomas and older female patients with small squamous cell carcinomas (p = .05). We conclude that the relationship between tumor volume and age is complex and dependent on patient gender and tumor cell type.</abstract><cop>United States</cop><pub>The Gerontological Society of America</pub><pmid>8548500</pmid><doi>10.1093/gerona/51A.1.B50</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1079-5006 |
| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 1996-01, Vol.51A (1), p.B50-B53 |
| issn | 1079-5006 1758-535X |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Periodicals Index Online |
| subjects | Adenocarcinoma - pathology Adolescent Adult Age Age Factors Aged Aged, 80 and over Carcinoid Tumor - pathology Carcinoma, Large Cell - pathology Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - pathology Cellular biology Female Humans Lung cancer Lung Neoplasms - pathology Male Middle Aged Neoplasm Metastasis Retrospective Studies Sex Factors Sexes Tumors |
| title | Correlates of Tumor Size, Gender, Cell Type, and Metastasis of Resected Non-Small Cell Lung Cancer and Age |
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