Correlation between glutathione and stimulation of the pentose phosphate cycle in situ in Chinese hamster ovary cells exposed to hydrogen peroxide

The effect of glutathione on stimulation of pentose phosphate cycle activity during oxidative challenge was evaluated in intact Chinese hamster ovary cells in situ. Glutathione was depleted to varying levels with L-buthionine-[S,R] sulfoximine. The level of stimulation of pentose phosphate cycle act...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1996-01, Vol.325 (1), p.91-98
Hauptverfasser:	Przybytkowski, E, Averill-Bates, D A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitrole - pharmacology Animals Buthionine Sulfoximine Carmustine - pharmacology CHO Cells Cricetinae Enzyme Inhibitors - pharmacology Glucosephosphate Dehydrogenase - metabolism Glutamate-Cysteine Ligase - antagonists & inhibitors Glutathione - metabolism Hydrogen Peroxide - pharmacology Kinetics Methionine Sulfoximine - analogs & derivatives Methionine Sulfoximine - pharmacology Oxidation-Reduction Paraquat - pharmacology Pentose Phosphate Pathway - drug effects
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