Insulin as a factor of increased androgen production in women with obesity and polycystic ovaries
To evaluate the possible role of moderate hyperinsulinemia on abnormal androgen secretion, we examined 4 age and weight-matched groups of obese subjects: 2 groups of women with normal menses whose fasting insulin (IRI) levels were less than or equal to 20 microU/ml (OB-I) or greater than or equal to...
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| Veröffentlicht in: | Journal of endocrinological investigation 1987-12, Vol.10 (6), p.575-579 |
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| container_title | Journal of endocrinological investigation |
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| creator | PASQUALI, R ANTENUCCI, D CASIMIRRI, F VENTUROLI, S PARADISI, R FABBRI, R MELCHIONDA, N BARBARA, L |
| description | To evaluate the possible role of moderate hyperinsulinemia on abnormal androgen secretion, we examined 4 age and weight-matched groups of obese subjects: 2 groups of women with normal menses whose fasting insulin (IRI) levels were less than or equal to 20 microU/ml (OB-I) or greater than or equal to 40 microU/ml (OB-I) and 2 groups of women with polycystic ovaries who were similarly grouped. All subjects underwent an oral glucose tolerance test, blood sex hormone determination and multiple LH determinations. Compared to OB, OB-PCO women showed significantly higher values of LH, androgen and estrogen concentrations. OB-I and OB-II showed similar hormonal patterns. On the contrary, OB-PCO-II presented significantly (p less than 0.05) higher androstenedione concentrations (348.7 +/- 129.9 ng/dl) (m +/- SD) than OB-PCO-I women (237.0 +/- 73.7 ng/dl). These differences were evident despite similar plasma LH concentrations. In conclusion, these results suggest that insulin may be a factor amplifying LH-dependent androgen secretion in hyperandrogenized women with obesity and PCO. |
| doi_str_mv | 10.1007/BF03346997 |
| format | Article |
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All subjects underwent an oral glucose tolerance test, blood sex hormone determination and multiple LH determinations. Compared to OB, OB-PCO women showed significantly higher values of LH, androgen and estrogen concentrations. OB-I and OB-II showed similar hormonal patterns. On the contrary, OB-PCO-II presented significantly (p less than 0.05) higher androstenedione concentrations (348.7 +/- 129.9 ng/dl) (m +/- SD) than OB-PCO-I women (237.0 +/- 73.7 ng/dl). These differences were evident despite similar plasma LH concentrations. In conclusion, these results suggest that insulin may be a factor amplifying LH-dependent androgen secretion in hyperandrogenized women with obesity and PCO.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/BF03346997</identifier><identifier>PMID: 3326891</identifier><identifier>CODEN: JEIND7</identifier><language>eng</language><publisher>Milano: Kurtis</publisher><subject>Androgens - biosynthesis ; Androgens - blood ; Androgens - secretion ; Biological and medical sciences ; Estrogens - blood ; Female ; Glucose Tolerance Test ; Gonadotropins, Pituitary - blood ; Humans ; Hyperinsulinism - metabolism ; Insulin - physiology ; Insulin Resistance ; Luteinizing Hormone - blood ; Luteinizing Hormone - physiology ; Luteinizing Hormone - secretion ; Medical sciences ; Metabolic diseases ; Obesity ; Obesity - metabolism ; Polycystic Ovary Syndrome - metabolism</subject><ispartof>Journal of endocrinological investigation, 1987-12, Vol.10 (6), p.575-579</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-b2950d2209ec364aaa4422267c1b10d0bbe9175b953e11371b87afdf2317be273</citedby><cites>FETCH-LOGICAL-c342t-b2950d2209ec364aaa4422267c1b10d0bbe9175b953e11371b87afdf2317be273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7835505$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3326891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PASQUALI, R</creatorcontrib><creatorcontrib>ANTENUCCI, D</creatorcontrib><creatorcontrib>CASIMIRRI, F</creatorcontrib><creatorcontrib>VENTUROLI, S</creatorcontrib><creatorcontrib>PARADISI, R</creatorcontrib><creatorcontrib>FABBRI, R</creatorcontrib><creatorcontrib>MELCHIONDA, N</creatorcontrib><creatorcontrib>BARBARA, L</creatorcontrib><title>Insulin as a factor of increased androgen production in women with obesity and polycystic ovaries</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>To evaluate the possible role of moderate hyperinsulinemia on abnormal androgen secretion, we examined 4 age and weight-matched groups of obese subjects: 2 groups of women with normal menses whose fasting insulin (IRI) levels were less than or equal to 20 microU/ml (OB-I) or greater than or equal to 40 microU/ml (OB-I) and 2 groups of women with polycystic ovaries who were similarly grouped. All subjects underwent an oral glucose tolerance test, blood sex hormone determination and multiple LH determinations. Compared to OB, OB-PCO women showed significantly higher values of LH, androgen and estrogen concentrations. OB-I and OB-II showed similar hormonal patterns. On the contrary, OB-PCO-II presented significantly (p less than 0.05) higher androstenedione concentrations (348.7 +/- 129.9 ng/dl) (m +/- SD) than OB-PCO-I women (237.0 +/- 73.7 ng/dl). These differences were evident despite similar plasma LH concentrations. In conclusion, these results suggest that insulin may be a factor amplifying LH-dependent androgen secretion in hyperandrogenized women with obesity and PCO.</description><subject>Androgens - biosynthesis</subject><subject>Androgens - blood</subject><subject>Androgens - secretion</subject><subject>Biological and medical sciences</subject><subject>Estrogens - blood</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Gonadotropins, Pituitary - blood</subject><subject>Humans</subject><subject>Hyperinsulinism - metabolism</subject><subject>Insulin - physiology</subject><subject>Insulin Resistance</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - physiology</subject><subject>Luteinizing Hormone - secretion</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAUx4Moc04v3oUcxINQza82zVGH08HAi57LS5pqpGtm0jr639uxMo-eHrzvh-97fBC6pOSOEiLvHxeEc5EpJY_QlEpGkpzn2TGaEq5oIoiSp-gsxi9CuOS5nKAJ5yzLFZ0iWDaxq12DIWLAFZjWB-wr7BoTLERbYmjK4D9sgzfBl51pnW-GFG_9ethtXfuJvbbRtf2OxBtf96aPrTPY_0BwNp6jkwrqaC_GOUPvi6e3-Uuyen1ezh9WieGCtYlmKiUlY0RZwzMBAEIwxjJpqKakJFpbRWWqVcotpVxSnUuoyopxKrVlks_Qzb53-PO7s7Et1i4aW9fQWN_FQkqVCSHFvyAViopsuDFDt3vQBB9jsFWxCW4NoS8oKXbiiz_xA3w1tnZ6bcsDOpoe8usxh2igrgI0xsUDJnOepiTlv7Epihk</recordid><startdate>19871201</startdate><enddate>19871201</enddate><creator>PASQUALI, R</creator><creator>ANTENUCCI, D</creator><creator>CASIMIRRI, F</creator><creator>VENTUROLI, S</creator><creator>PARADISI, R</creator><creator>FABBRI, R</creator><creator>MELCHIONDA, N</creator><creator>BARBARA, L</creator><general>Kurtis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19871201</creationdate><title>Insulin as a factor of increased androgen production in women with obesity and polycystic ovaries</title><author>PASQUALI, R ; ANTENUCCI, D ; CASIMIRRI, F ; VENTUROLI, S ; PARADISI, R ; FABBRI, R ; MELCHIONDA, N ; BARBARA, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-b2950d2209ec364aaa4422267c1b10d0bbe9175b953e11371b87afdf2317be273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Androgens - biosynthesis</topic><topic>Androgens - blood</topic><topic>Androgens - secretion</topic><topic>Biological and medical sciences</topic><topic>Estrogens - blood</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Gonadotropins, Pituitary - blood</topic><topic>Humans</topic><topic>Hyperinsulinism - metabolism</topic><topic>Insulin - physiology</topic><topic>Insulin Resistance</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - physiology</topic><topic>Luteinizing Hormone - secretion</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PASQUALI, R</creatorcontrib><creatorcontrib>ANTENUCCI, D</creatorcontrib><creatorcontrib>CASIMIRRI, F</creatorcontrib><creatorcontrib>VENTUROLI, S</creatorcontrib><creatorcontrib>PARADISI, R</creatorcontrib><creatorcontrib>FABBRI, R</creatorcontrib><creatorcontrib>MELCHIONDA, N</creatorcontrib><creatorcontrib>BARBARA, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PASQUALI, R</au><au>ANTENUCCI, D</au><au>CASIMIRRI, F</au><au>VENTUROLI, S</au><au>PARADISI, R</au><au>FABBRI, R</au><au>MELCHIONDA, N</au><au>BARBARA, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin as a factor of increased androgen production in women with obesity and polycystic ovaries</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>1987-12-01</date><risdate>1987</risdate><volume>10</volume><issue>6</issue><spage>575</spage><epage>579</epage><pages>575-579</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><coden>JEIND7</coden><abstract>To evaluate the possible role of moderate hyperinsulinemia on abnormal androgen secretion, we examined 4 age and weight-matched groups of obese subjects: 2 groups of women with normal menses whose fasting insulin (IRI) levels were less than or equal to 20 microU/ml (OB-I) or greater than or equal to 40 microU/ml (OB-I) and 2 groups of women with polycystic ovaries who were similarly grouped. All subjects underwent an oral glucose tolerance test, blood sex hormone determination and multiple LH determinations. Compared to OB, OB-PCO women showed significantly higher values of LH, androgen and estrogen concentrations. OB-I and OB-II showed similar hormonal patterns. On the contrary, OB-PCO-II presented significantly (p less than 0.05) higher androstenedione concentrations (348.7 +/- 129.9 ng/dl) (m +/- SD) than OB-PCO-I women (237.0 +/- 73.7 ng/dl). These differences were evident despite similar plasma LH concentrations. In conclusion, these results suggest that insulin may be a factor amplifying LH-dependent androgen secretion in hyperandrogenized women with obesity and PCO.</abstract><cop>Milano</cop><pub>Kurtis</pub><pmid>3326891</pmid><doi>10.1007/BF03346997</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Androgens - biosynthesis Androgens - blood Androgens - secretion Biological and medical sciences Estrogens - blood Female Glucose Tolerance Test Gonadotropins, Pituitary - blood Humans Hyperinsulinism - metabolism Insulin - physiology Insulin Resistance Luteinizing Hormone - blood Luteinizing Hormone - physiology Luteinizing Hormone - secretion Medical sciences Metabolic diseases Obesity Obesity - metabolism Polycystic Ovary Syndrome - metabolism |
| title | Insulin as a factor of increased androgen production in women with obesity and polycystic ovaries |
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