Pentalenolactone-insensitive glyceraldehyde-3-phosphate dehydrogenase from Streptomyces arenae is closely related to GAPDH from thermostable eubacteria and plant chloroplasts

Streptomyces arenae produces the antibiotic pentalenolactone, a highly specific inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). During the phase of pentalenolactone production, S. arenae expresses a pentalenolactone-insensitive GAPDH isoform; otherwise, a pentalenolactone-sensitive fo...

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Veröffentlicht in:	Archives of microbiology 1996-03, Vol.165 (3), p.179-186
Hauptverfasser:	FRÖHLICH, K.-U, KANNWISCHER, R, RÜDIGER, M, MECKE, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - pharmacology Bacteria - enzymology Bacteriology Base Composition Base Sequence Biological and medical sciences Chloroplasts - enzymology Cloning, Molecular Drug Resistance, Microbial Enzyme Stability Fundamental and applied biological sciences. Psychology Glyceraldehyde-3-Phosphate Dehydrogenases - chemistry Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Glyceraldehyde-3-Phosphate Dehydrogenases - isolation & purification Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Metabolism. Enzymes Microbiology Molecular Sequence Data Phylogeny Plants - enzymology Sequence Analysis, DNA Sesquiterpenes - pharmacology Streptomyces - drug effects Streptomyces - enzymology Streptomyces - genetics Streptomyces arenae Temperature
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