Circulating Factor Associated with Increased Glomerular Permeability to Albumin in Recurrent Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis develops and progresses to renal failure in some patients who have idiopathic nephrotic syndrome that is resistant to treatment with corticosteroids and cytotoxic drugs. 1 – 3 After transplantation, up to 40 percent of such patients have recurrences. 4 – 9 The glom...
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| Veröffentlicht in: | The New England journal of medicine 1996-04, Vol.334 (14), p.878-883 |
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| container_title | The New England journal of medicine |
| container_volume | 334 |
| creator | Savin, Virginia J Sharma, Mukut Sharma, Ram McCarthy, Ellen T Swan, Suzanne K Ellis, Eileen Lovell, Helen Warady, Bradley Gunwar, Sripad Chonko, Arnold M Artero, Mary Vincenti, Flavio |
| description | Focal segmental glomerulosclerosis develops and progresses to renal failure in some patients who have idiopathic nephrotic syndrome that is resistant to treatment with corticosteroids and cytotoxic drugs.
1
–
3
After transplantation, up to 40 percent of such patients have recurrences.
4
–
9
The glomerular abnormalities in patients with established disease include focal and segmental glomerulosclerosis and hyalinosis, although fusion of epithelial-cell foot processes may be the only abnormality early in the course of the disease.
10
It has been proposed that because some patients with recurrent focal segmental glomerulosclerosis have a response to treatment with plasmapheresis,
11
–
16
there may be a circulating factor . . . |
| doi_str_mv | 10.1056/NEJM199604043341402 |
| format | Article |
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1
–
3
After transplantation, up to 40 percent of such patients have recurrences.
4
–
9
The glomerular abnormalities in patients with established disease include focal and segmental glomerulosclerosis and hyalinosis, although fusion of epithelial-cell foot processes may be the only abnormality early in the course of the disease.
10
It has been proposed that because some patients with recurrent focal segmental glomerulosclerosis have a response to treatment with plasmapheresis,
11
–
16
there may be a circulating factor . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199604043341402</identifier><identifier>PMID: 8596570</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Albumins - pharmacokinetics ; Animals ; Biological and medical sciences ; Disease ; Female ; Glomerulosclerosis, Focal Segmental - blood ; Glomerulosclerosis, Focal Segmental - metabolism ; Glomerulosclerosis, Focal Segmental - therapy ; Humans ; Investigative techniques of renal and urinary tract function ; Investigative techniques, diagnostic techniques (general aspects) ; Kidney Diseases - blood ; Kidney Glomerulus - metabolism ; Kidney Transplantation ; Kidneys ; Male ; Medical sciences ; Microscopy ; Permeability ; Plasmapheresis ; Rats ; Rats, Sprague-Dawley ; Recurrence ; Reference Values ; Rodents</subject><ispartof>The New England journal of medicine, 1996-04, Vol.334 (14), p.878-883</ispartof><rights>Copyright © 1996 Massachusetts Medical Society. All rights reserved.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-b51f50cdd605ed9cfe88bd789e06f938b25897624df3811cc7f0693ec6fcb2fe3</citedby><cites>FETCH-LOGICAL-c578t-b51f50cdd605ed9cfe88bd789e06f938b25897624df3811cc7f0693ec6fcb2fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199604043341402$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199604043341402$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3033517$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8596570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Savin, Virginia J</creatorcontrib><creatorcontrib>Sharma, Mukut</creatorcontrib><creatorcontrib>Sharma, Ram</creatorcontrib><creatorcontrib>McCarthy, Ellen T</creatorcontrib><creatorcontrib>Swan, Suzanne K</creatorcontrib><creatorcontrib>Ellis, Eileen</creatorcontrib><creatorcontrib>Lovell, Helen</creatorcontrib><creatorcontrib>Warady, Bradley</creatorcontrib><creatorcontrib>Gunwar, Sripad</creatorcontrib><creatorcontrib>Chonko, Arnold M</creatorcontrib><creatorcontrib>Artero, Mary</creatorcontrib><creatorcontrib>Vincenti, Flavio</creatorcontrib><title>Circulating Factor Associated with Increased Glomerular Permeability to Albumin in Recurrent Focal Segmental Glomerulosclerosis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Focal segmental glomerulosclerosis develops and progresses to renal failure in some patients who have idiopathic nephrotic syndrome that is resistant to treatment with corticosteroids and cytotoxic drugs.
1
–
3
After transplantation, up to 40 percent of such patients have recurrences.
4
–
9
The glomerular abnormalities in patients with established disease include focal and segmental glomerulosclerosis and hyalinosis, although fusion of epithelial-cell foot processes may be the only abnormality early in the course of the disease.
10
It has been proposed that because some patients with recurrent focal segmental glomerulosclerosis have a response to treatment with plasmapheresis,
11
–
16
there may be a circulating factor . . .</description><subject>Adult</subject><subject>Albumins - pharmacokinetics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease</subject><subject>Female</subject><subject>Glomerulosclerosis, Focal Segmental - blood</subject><subject>Glomerulosclerosis, Focal Segmental - metabolism</subject><subject>Glomerulosclerosis, Focal Segmental - therapy</subject><subject>Humans</subject><subject>Investigative techniques of renal and urinary tract function</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidney Diseases - blood</subject><subject>Kidney Glomerulus - metabolism</subject><subject>Kidney Transplantation</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy</subject><subject>Permeability</subject><subject>Plasmapheresis</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recurrence</subject><subject>Reference Values</subject><subject>Rodents</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kV1rFDEUhoModa3-AhGCiDcyNZl8THK5LN1aaVX8uB4ymZOaJZnUZAbpVf-60V17UcQQyDmc5z0nyYvQc0pOKBHy7YfT95dUa0k44Yxxykn7AK2oYKzhnMiHaEVIqxreafYYPSllR-qiXB-hIyW0FB1ZoduNz3YJZvbTFd4aO6eM16Uk680MI_7p5-_4fLIZTKnpWUgRcsUz_gQ5ghl88PMNnhNeh2GJfsJ1fwa75AzTjLfJmoC_wFWsWY3-6lOxAXIqvjxFj5wJBZ4dzmP0bXv6dfOuufh4dr5ZXzRWdGpuBkGdIHYcJREwautAqWHslAYinWZqaIXSnWz56Jii1NrOEakZWOns0Dpgx-j1vu91Tj8WKHMffbEQgpkgLaXvOi0pIbKCL--Bu7Tkqd6tb1umNeW0qxDbQ7Y-omRw_XX20eSbnpL-tzf9P7ypqheH1ssQYbzTHMyo9VeHuin131w2k_XlDmOEMfFn-Js9FmPpJ9jF_w79BetKpNA</recordid><startdate>19960404</startdate><enddate>19960404</enddate><creator>Savin, Virginia J</creator><creator>Sharma, Mukut</creator><creator>Sharma, Ram</creator><creator>McCarthy, Ellen T</creator><creator>Swan, Suzanne K</creator><creator>Ellis, Eileen</creator><creator>Lovell, Helen</creator><creator>Warady, Bradley</creator><creator>Gunwar, Sripad</creator><creator>Chonko, Arnold M</creator><creator>Artero, Mary</creator><creator>Vincenti, Flavio</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19960404</creationdate><title>Circulating Factor Associated with Increased Glomerular Permeability to Albumin in Recurrent Focal Segmental Glomerulosclerosis</title><author>Savin, Virginia J ; Sharma, Mukut ; Sharma, Ram ; McCarthy, Ellen T ; Swan, Suzanne K ; Ellis, Eileen ; Lovell, Helen ; Warady, Bradley ; Gunwar, Sripad ; Chonko, Arnold M ; Artero, Mary ; Vincenti, Flavio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-b51f50cdd605ed9cfe88bd789e06f938b25897624df3811cc7f0693ec6fcb2fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Albumins - pharmacokinetics</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease</topic><topic>Female</topic><topic>Glomerulosclerosis, Focal Segmental - blood</topic><topic>Glomerulosclerosis, Focal Segmental - metabolism</topic><topic>Glomerulosclerosis, Focal Segmental - therapy</topic><topic>Humans</topic><topic>Investigative techniques of renal and urinary tract function</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kidney Diseases - blood</topic><topic>Kidney Glomerulus - metabolism</topic><topic>Kidney Transplantation</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy</topic><topic>Permeability</topic><topic>Plasmapheresis</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recurrence</topic><topic>Reference Values</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savin, Virginia J</creatorcontrib><creatorcontrib>Sharma, Mukut</creatorcontrib><creatorcontrib>Sharma, Ram</creatorcontrib><creatorcontrib>McCarthy, Ellen T</creatorcontrib><creatorcontrib>Swan, Suzanne K</creatorcontrib><creatorcontrib>Ellis, Eileen</creatorcontrib><creatorcontrib>Lovell, Helen</creatorcontrib><creatorcontrib>Warady, Bradley</creatorcontrib><creatorcontrib>Gunwar, Sripad</creatorcontrib><creatorcontrib>Chonko, Arnold M</creatorcontrib><creatorcontrib>Artero, Mary</creatorcontrib><creatorcontrib>Vincenti, Flavio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savin, Virginia J</au><au>Sharma, Mukut</au><au>Sharma, Ram</au><au>McCarthy, Ellen T</au><au>Swan, Suzanne K</au><au>Ellis, Eileen</au><au>Lovell, Helen</au><au>Warady, Bradley</au><au>Gunwar, Sripad</au><au>Chonko, Arnold M</au><au>Artero, Mary</au><au>Vincenti, Flavio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Factor Associated with Increased Glomerular Permeability to Albumin in Recurrent Focal Segmental Glomerulosclerosis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1996-04-04</date><risdate>1996</risdate><volume>334</volume><issue>14</issue><spage>878</spage><epage>883</epage><pages>878-883</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Focal segmental glomerulosclerosis develops and progresses to renal failure in some patients who have idiopathic nephrotic syndrome that is resistant to treatment with corticosteroids and cytotoxic drugs.
1
–
3
After transplantation, up to 40 percent of such patients have recurrences.
4
–
9
The glomerular abnormalities in patients with established disease include focal and segmental glomerulosclerosis and hyalinosis, although fusion of epithelial-cell foot processes may be the only abnormality early in the course of the disease.
10
It has been proposed that because some patients with recurrent focal segmental glomerulosclerosis have a response to treatment with plasmapheresis,
11
–
16
there may be a circulating factor . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>8596570</pmid><doi>10.1056/NEJM199604043341402</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1996-04, Vol.334 (14), p.878-883 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77961006 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine Current |
| subjects | Adult Albumins - pharmacokinetics Animals Biological and medical sciences Disease Female Glomerulosclerosis, Focal Segmental - blood Glomerulosclerosis, Focal Segmental - metabolism Glomerulosclerosis, Focal Segmental - therapy Humans Investigative techniques of renal and urinary tract function Investigative techniques, diagnostic techniques (general aspects) Kidney Diseases - blood Kidney Glomerulus - metabolism Kidney Transplantation Kidneys Male Medical sciences Microscopy Permeability Plasmapheresis Rats Rats, Sprague-Dawley Recurrence Reference Values Rodents |
| title | Circulating Factor Associated with Increased Glomerular Permeability to Albumin in Recurrent Focal Segmental Glomerulosclerosis |
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