RNA recognition and translational regulation by a homeodomain protein
In Drosophila , the primary determinant of anterior pattern is the gradient morphogen bicoid (bed), a homeodomain protein that binds DMA and transcriptionally activates target genes at different threshold concentrations. Here we present evidence that bed also binds RNA and acts as a translational re...
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| Veröffentlicht in: | Nature (London) 1996-02, Vol.379 (6567), p.694-699 |
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| creator | Dubnau, Josh Struhl, Gary |
| description | In
Drosophila
, the primary determinant of anterior pattern is the gradient morphogen bicoid (bed), a homeodomain protein that binds DMA and transcriptionally activates target genes at different threshold concentrations. Here we present evidence that bed also binds RNA and acts as a translational represser to generate an opposing gradient of the homeodomain protein caudal (cad). RNA binding by bed seems to involve direct interactions between the bed homeodomain and discrete target sequences within the 3′ untranslated region of the
cad
messenger RNA and to block the initiation of cad translation. |
| doi_str_mv | 10.1038/379694a0 |
| format | Article |
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Drosophila
, the primary determinant of anterior pattern is the gradient morphogen bicoid (bed), a homeodomain protein that binds DMA and transcriptionally activates target genes at different threshold concentrations. Here we present evidence that bed also binds RNA and acts as a translational represser to generate an opposing gradient of the homeodomain protein caudal (cad). RNA binding by bed seems to involve direct interactions between the bed homeodomain and discrete target sequences within the 3′ untranslated region of the
cad
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Drosophila
, the primary determinant of anterior pattern is the gradient morphogen bicoid (bed), a homeodomain protein that binds DMA and transcriptionally activates target genes at different threshold concentrations. Here we present evidence that bed also binds RNA and acts as a translational represser to generate an opposing gradient of the homeodomain protein caudal (cad). RNA binding by bed seems to involve direct interactions between the bed homeodomain and discrete target sequences within the 3′ untranslated region of the
cad
messenger RNA and to block the initiation of cad translation.</description><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Cell division</subject><subject>Cell Line</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Embryos</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Insect Hormones - metabolism</subject><subject>Insects</subject><subject>Introns</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Peptide Chain Initiation, Translational</subject><subject>Peptide Fragments - metabolism</subject><subject>Protein Biosynthesis</subject><subject>Proteins</subject><subject>Recombinant Fusion Proteins - metabolism</subject><subject>Regulatory Sequences, Nucleic Acid</subject><subject>Repressor Proteins - metabolism</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Trans-Activators</subject><subject>Transcription Factors</subject><subject>Translation. 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubnau, Josh</au><au>Struhl, Gary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RNA recognition and translational regulation by a homeodomain protein</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1996-02-22</date><risdate>1996</risdate><volume>379</volume><issue>6567</issue><spage>694</spage><epage>699</epage><pages>694-699</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>In
Drosophila
, the primary determinant of anterior pattern is the gradient morphogen bicoid (bed), a homeodomain protein that binds DMA and transcriptionally activates target genes at different threshold concentrations. Here we present evidence that bed also binds RNA and acts as a translational represser to generate an opposing gradient of the homeodomain protein caudal (cad). RNA binding by bed seems to involve direct interactions between the bed homeodomain and discrete target sequences within the 3′ untranslated region of the
cad
messenger RNA and to block the initiation of cad translation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8602214</pmid><doi>10.1038/379694a0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1996-02, Vol.379 (6567), p.694-699 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77960509 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Animals Animals, Genetically Modified Base Sequence Binding Sites Biological and medical sciences Cell division Cell Line Deoxyribonucleic acid DNA Drosophila Drosophila - embryology Drosophila - genetics Drosophila Proteins Embryos Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humanities and Social Sciences Insect Hormones - metabolism Insects Introns Molecular and cellular biology Molecular genetics Molecular Sequence Data multidisciplinary Peptide Chain Initiation, Translational Peptide Fragments - metabolism Protein Biosynthesis Proteins Recombinant Fusion Proteins - metabolism Regulatory Sequences, Nucleic Acid Repressor Proteins - metabolism Ribonucleic acid RNA RNA, Messenger - metabolism RNA-Binding Proteins - metabolism Science Science (multidisciplinary) Trans-Activators Transcription Factors Translation. Translation factors. Protein processing |
| title | RNA recognition and translational regulation by a homeodomain protein |
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