Baclofen, a gamma-aminobutyric acid B agonist, modifies hormonal secretion in pituitary cells from infantile female rats

Recent work from our laboratory has demonstrated that the activation of GABA B adenohypophyseal receptors by baclofen inhibits pituitary hormone secretion under basal (PRL) or stimulated conditions (PRL and LH) in adult female rats, suggesting a hypophyseal site of action in additon to the central s...

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Veröffentlicht in:	Life sciences (1973) 1996, Vol.58 (13), p.1059-1065
Hauptverfasser:	Rey-Roldan, Estela B., Lux-Lantos, Victoria A.R., González-Iglesias, Arturo E., Becú-Villalobos, Damasia, Libertun, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals baclofen Baclofen - pharmacology Cells, Cultured Dose-Response Relationship, Drug Female Follicle Stimulating Hormone - metabolism GABA Agonists - pharmacology Gonadotropin-Releasing Hormone - pharmacology infantile female rats Kinetics Luteinizing Hormone - metabolism pituitary cells Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Rats Rats, Sprague-Dawley Receptors, GABA-B - physiology Thyrotropin - metabolism
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