Transfection of an Invasive Human Astrocytoma Cell Line with a TIMP-1 cDNA: Modulation of Astrocytoma Invasive Potential

Malignant astrocytomas are highly invasive tumors which infiltrate diffusely into regions of normal brain. The degradation of the extracellular matrix (ECM) by matrix metalloproteinases is thought to be one of the most important steps in the process of tumor invasion. However, the activity of most m...

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