In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832

PD 151832 is a potent partial muscarinic agonist that displays a high level of functional selectivity for the muscarinic m1 receptor subtype, as evidenced by its selective stimulation of PI turnover and cellular metabolic activity in transfected Hm1-CHO cells at concentrations that produce minimal s...

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Veröffentlicht in:	Life sciences (1973) 1995, Vol.56 (11), p.845-852
Hauptverfasser:	Jaen, J., Barrett, S., Brann, M., Callahan, M., Davis, R., Doyle, P., Eubanks, D., Lauffer, D., Lauffer, L., Lipinski, W., Moreland, D., Nelson, C., Raby, C., Schwarz, R., Spencer, C., Tecle, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - metabolism Animals Bridged Bicyclo Compounds, Heterocyclic - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - metabolism CHO Cells cholinomimetic Cricetinae Drug Evaluation, Preclinical Gastric Emptying - drug effects Gastric Emptying - physiology Humans m1-receptor Male Maze Learning - drug effects Mice Mice, Inbred C57BL Muscarinic Agonists - classification Muscarinic Agonists - metabolism Muscarinic Agonists - pharmacology muscarinic subtype Oximes - metabolism Oximes - pharmacology Phosphatidylinositols - metabolism Radioligand Assay Rats Receptor, Muscarinic M1 Receptors, Muscarinic - metabolism Structure-Activity Relationship Transfection
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