Antibody VH Domains as Small Recognition Units

To develop immunoglobulin based recognition units of minimum size, a human heavy chain variable domain (VH) was designed for selection of phage displayed VH. Non-specific binding of the VH through its interface for the light chain variable domain (VL) was prevented through three mutations (G44E, L45...

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Veröffentlicht in:	Bio/Technology 1995-05, Vol.13 (5), p.475-479
Hauptverfasser:	Davies, Julian, Riechmann, Lutz
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino Acid Sequence Antibody Specificity Antigen-Antibody Reactions Bacteriophages Base Sequence Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Escherichia coli Fundamental and applied biological sciences. Psychology Genes. Genome Humans Immunoglobulin Variable Region Life Sciences Molecular and cellular biology Molecular genetics Molecular Sequence Data Molecular Weight Peptide Library Protein Binding Protein Structure, Tertiary Templates, Genetic
Online-Zugang:	Volltext
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