Altered Sensory Processing in the Somatosensory Cortex of the Mouse Mutant Barrelless
Mice homozygous for the barrelless (brl) mutation, mapped here to chromosome 11, lack barrel-shaped arrays of cell clusters termed "barrels" in the primary somatosensory cortex. Deoxyglucose uptake demonstrated that the topology of the cortical whisker representation in nevertheless preser...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-03, Vol.271 (5257), p.1864-1867 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Welker, E. Armstrong-James, M. Bronchti, G. Ourednik, W. Gheorghita-Baechler, F. Dubois, R. Guernsey, D. L. Van der Loos, H. Neumann, P. E. |
| description | Mice homozygous for the barrelless (brl) mutation, mapped here to chromosome 11, lack barrel-shaped arrays of cell clusters termed "barrels" in the primary somatosensory cortex. Deoxyglucose uptake demonstrated that the topology of the cortical whisker representation in nevertheless preserved. Anterograde tracers revealed a lack of spatial segregation of thalamic afferents into individual barrel territories, and single-cell recordings demonstrated a lack of temporal discrimination of center from surround information. Thus, structural segregation of thalamic inputs is not essential to generate topological order in the somatosensory cortex, but it is required for discrete spatiotemporal relay of sensory information to the cortex. |
| doi_str_mv | 10.1126/science.271.5257.1864 |
| format | Article |
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L. ; Van der Loos, H. ; Neumann, P. E.</creator><creatorcontrib>Welker, E. ; Armstrong-James, M. ; Bronchti, G. ; Ourednik, W. ; Gheorghita-Baechler, F. ; Dubois, R. ; Guernsey, D. L. ; Van der Loos, H. ; Neumann, P. E.</creatorcontrib><description>Mice homozygous for the barrelless (brl) mutation, mapped here to chromosome 11, lack barrel-shaped arrays of cell clusters termed "barrels" in the primary somatosensory cortex. Deoxyglucose uptake demonstrated that the topology of the cortical whisker representation in nevertheless preserved. Anterograde tracers revealed a lack of spatial segregation of thalamic afferents into individual barrel territories, and single-cell recordings demonstrated a lack of temporal discrimination of center from surround information. Thus, structural segregation of thalamic inputs is not essential to generate topological order in the somatosensory cortex, but it is required for discrete spatiotemporal relay of sensory information to the cortex.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.271.5257.1864</identifier><identifier>PMID: 8596955</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Anatomy ; Animals ; Axons ; Axons - ultrastructure ; Biological and medical sciences ; Brain ; Brain - cytology ; Brain - metabolism ; Brain stem ; Cellular biology ; Cerebral cortex ; Chromosome Mapping ; Deoxyglucose - metabolism ; Feedback (Response) ; Follicles ; Fundamental and applied biological sciences. 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Sensory receptors ; Thalamus - cytology ; Thalamus - physiology ; Topology ; Vertebrates: nervous system and sense organs ; Vibrissae - innervation ; Vibrissae - physiology</subject><ispartof>Science (American Association for the Advancement of Science), 1996-03, Vol.271 (5257), p.1864-1867</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Mar 29, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c815t-4f0eb986ff549551376354f8c2fad149ccc4d8730268f92ea6d15808d12b38d3</citedby><cites>FETCH-LOGICAL-c815t-4f0eb986ff549551376354f8c2fad149ccc4d8730268f92ea6d15808d12b38d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2889379$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2889379$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3032844$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8596955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Welker, E.</creatorcontrib><creatorcontrib>Armstrong-James, M.</creatorcontrib><creatorcontrib>Bronchti, G.</creatorcontrib><creatorcontrib>Ourednik, W.</creatorcontrib><creatorcontrib>Gheorghita-Baechler, F.</creatorcontrib><creatorcontrib>Dubois, R.</creatorcontrib><creatorcontrib>Guernsey, D. L.</creatorcontrib><creatorcontrib>Van der Loos, H.</creatorcontrib><creatorcontrib>Neumann, P. E.</creatorcontrib><title>Altered Sensory Processing in the Somatosensory Cortex of the Mouse Mutant Barrelless</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Mice homozygous for the barrelless (brl) mutation, mapped here to chromosome 11, lack barrel-shaped arrays of cell clusters termed "barrels" in the primary somatosensory cortex. Deoxyglucose uptake demonstrated that the topology of the cortical whisker representation in nevertheless preserved. Anterograde tracers revealed a lack of spatial segregation of thalamic afferents into individual barrel territories, and single-cell recordings demonstrated a lack of temporal discrimination of center from surround information. Thus, structural segregation of thalamic inputs is not essential to generate topological order in the somatosensory cortex, but it is required for discrete spatiotemporal relay of sensory information to the cortex.</description><subject>Anatomy</subject><subject>Animals</subject><subject>Axons</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - cytology</subject><subject>Brain - metabolism</subject><subject>Brain stem</subject><subject>Cellular biology</subject><subject>Cerebral cortex</subject><subject>Chromosome Mapping</subject><subject>Deoxyglucose - metabolism</subject><subject>Feedback (Response)</subject><subject>Follicles</subject><subject>Fundamental and applied biological sciences. 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Sensory receptors</subject><subject>Thalamus - cytology</subject><subject>Thalamus - physiology</subject><subject>Topology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vibrissae - innervation</subject><subject>Vibrissae - physiology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNk12LEzEUhgdxWevqP3BhEBEvdmo-Jpnkslu0LlQrdPU2pJmkTpkmu0kG3H9vxg6FLoWWQAJ5n_NBct4su4ZgDCGin4NqtFV6jCo4JohUY8ho-SIbQcBJwRHAL7MRAJgWDFTkVfY6hA0ASeP4MrtkhFNOyCj7NWmj9rrOl9oG55_yn94pHUJj13lj8_hH50u3ldGFQZ86H_Xf3Jn_2nfXhbR3UdqY30rvddum6DfZhZFt0G-H8yq7__rlfvqtmC9md9PJvFAMkliUBugVZ9QYUqZuIK4oJqVhChlZw5IrpcqaVRggygxHWtIaEgZYDdEKsxpfZR93aR-8e-x0iGLbBJVakFanxkRVcUJJhU-CmKBUBJwGEYQMYMROgrACCBLKE_j-GbhxnbfpVVIyTGiJy77szQ5ay1aLxhoXvVRrbbWXrbPaNOl6AhlkJeJVwosjeFq13jbqGP_pgE9I-sO4ll0I4m7542x08fts9HZ2Lspm8wP05hiqXBqstRZpfKaLA5zscOVdCF4b8eCbrfRPAgLR-0QMPhHJJ6L3ieh9kuKuh2_pVltd76MGYyT9w6DLoGRrvLSqCXsM90NQ9mne7bBNiM7vZcQYxxXH_wCPKh_W</recordid><startdate>19960329</startdate><enddate>19960329</enddate><creator>Welker, E.</creator><creator>Armstrong-James, M.</creator><creator>Bronchti, G.</creator><creator>Ourednik, W.</creator><creator>Gheorghita-Baechler, F.</creator><creator>Dubois, R.</creator><creator>Guernsey, D. 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L.</au><au>Van der Loos, H.</au><au>Neumann, P. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered Sensory Processing in the Somatosensory Cortex of the Mouse Mutant Barrelless</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1996-03-29</date><risdate>1996</risdate><volume>271</volume><issue>5257</issue><spage>1864</spage><epage>1867</epage><pages>1864-1867</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Mice homozygous for the barrelless (brl) mutation, mapped here to chromosome 11, lack barrel-shaped arrays of cell clusters termed "barrels" in the primary somatosensory cortex. Deoxyglucose uptake demonstrated that the topology of the cortical whisker representation in nevertheless preserved. Anterograde tracers revealed a lack of spatial segregation of thalamic afferents into individual barrel territories, and single-cell recordings demonstrated a lack of temporal discrimination of center from surround information. Thus, structural segregation of thalamic inputs is not essential to generate topological order in the somatosensory cortex, but it is required for discrete spatiotemporal relay of sensory information to the cortex.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8596955</pmid><doi>10.1126/science.271.5257.1864</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-03, Vol.271 (5257), p.1864-1867 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77956573 |
| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Anatomy Animals Axons Axons - ultrastructure Biological and medical sciences Brain Brain - cytology Brain - metabolism Brain stem Cellular biology Cerebral cortex Chromosome Mapping Deoxyglucose - metabolism Feedback (Response) Follicles Fundamental and applied biological sciences. Psychology Human information processing Individualized Instruction Mice Mice, Mutant Strains Mutation Neural Pathways Neurons Neurons - cytology Neurons - physiology Neuroscience Pathology Phenotype Physiological aspects Rodents Senses Senses and sensation Sensory Experience Somatosensory cortex Somatosensory Cortex - cytology Somatosensory Cortex - metabolism Somatosensory Cortex - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Thalamus - cytology Thalamus - physiology Topology Vertebrates: nervous system and sense organs Vibrissae - innervation Vibrissae - physiology |
| title | Altered Sensory Processing in the Somatosensory Cortex of the Mouse Mutant Barrelless |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T03%3A50%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Altered%20Sensory%20Processing%20in%20the%20Somatosensory%20Cortex%20of%20the%20Mouse%20Mutant%20Barrelless&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Welker,%20E.&rft.date=1996-03-29&rft.volume=271&rft.issue=5257&rft.spage=1864&rft.epage=1867&rft.pages=1864-1867&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.271.5257.1864&rft_dat=%3Cgale_proqu%3EA18184297%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213564343&rft_id=info:pmid/8596955&rft_galeid=A18184297&rft_jstor_id=2889379&rfr_iscdi=true |