Surgery for Early Breast Cancer
To the Editor: Dr. Bailar (Nov. 30 issue) 1 reassures physicians and patients that the lumpectomy study findings of the National Surgical Adjuvant Breast and Bowel Project (NSABP) are credible. However, he asserts that until a much broader analysis of the entire cohort from St. Luc Hospital alone is...
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| Veröffentlicht in: | The New England journal of medicine 1996-04, Vol.334 (15), p.987-988 |
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| container_end_page | 988 |
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| container_issue | 15 |
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| container_title | The New England journal of medicine |
| container_volume | 334 |
| creator | Fisher, B Anderson, S Redmond, C K |
| description | To the Editor:
Dr. Bailar (Nov. 30 issue)
1
reassures physicians and patients that the lumpectomy study findings of the National Surgical Adjuvant Breast and Bowel Project (NSABP) are credible. However, he asserts that until a much broader analysis of the entire cohort from St. Luc Hospital alone is reported, all St. Luc data should be excluded from future interpretations of Protocol B-06. In fact, we did conduct extensive analyses to verify the integrity of the St. Luc data.
2
Presenting findings from a single institution compromises the integrity and conduct of multicenter trials. It also increases the chances of finding false . . . |
| doi_str_mv | 10.1056/NEJM199604113341512 |
| format | Article |
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Dr. Bailar (Nov. 30 issue)
1
reassures physicians and patients that the lumpectomy study findings of the National Surgical Adjuvant Breast and Bowel Project (NSABP) are credible. However, he asserts that until a much broader analysis of the entire cohort from St. Luc Hospital alone is reported, all St. Luc data should be excluded from future interpretations of Protocol B-06. In fact, we did conduct extensive analyses to verify the integrity of the St. Luc data.
2
Presenting findings from a single institution compromises the integrity and conduct of multicenter trials. It also increases the chances of finding false . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199604113341512</identifier><identifier>PMID: 8596604</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Breast Neoplasms - mortality ; Breast Neoplasms - surgery ; Confidence Intervals ; Female ; Humans ; Informed Consent ; Mastectomy, Segmental ; Medical Audit ; Randomized Controlled Trials as Topic - standards ; Survival Analysis</subject><ispartof>The New England journal of medicine, 1996-04, Vol.334 (15), p.987-988</ispartof><rights>Copyright © 1996 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c324t-8a41d9c625bb3c0b5046d5b1bfc5d36356632065faedf68ff2fb7bca8f6282a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199604113341512$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199604113341512$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8596604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fisher, B</creatorcontrib><creatorcontrib>Anderson, S</creatorcontrib><creatorcontrib>Redmond, C K</creatorcontrib><title>Surgery for Early Breast Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Dr. Bailar (Nov. 30 issue)
1
reassures physicians and patients that the lumpectomy study findings of the National Surgical Adjuvant Breast and Bowel Project (NSABP) are credible. However, he asserts that until a much broader analysis of the entire cohort from St. Luc Hospital alone is reported, all St. Luc data should be excluded from future interpretations of Protocol B-06. In fact, we did conduct extensive analyses to verify the integrity of the St. Luc data.
2
Presenting findings from a single institution compromises the integrity and conduct of multicenter trials. It also increases the chances of finding false . . .</description><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - surgery</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>Humans</subject><subject>Informed Consent</subject><subject>Mastectomy, Segmental</subject><subject>Medical Audit</subject><subject>Randomized Controlled Trials as Topic - standards</subject><subject>Survival Analysis</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EKiHwCxAiEwsK-PMSjxCVLxUYgNmyHRu1SppiJ0P_PUGpmBC33PDe80r3IHRK8BXBAq5f5k_PRErAnBDGOBGE7qGECMZyzjHsowRjWua8kOwQHcW4wuMQLmdoVgoJI5eg87chfLqwzXwXsrkOzTa7DU7HPqv02rpwjA68bqI72e0UfdzN36uHfPF6_1jdLHLLKO_zUnNSSwtUGMMsNgJzqIUhxltRM2ACgFEMwmtXeyi9p94UxurSAy2pBpaii6l3E7qvwcVetctoXdPoteuGqIpCCsDjnyli06ENXYzBebUJy1aHrSJY_WhRf2gZqbNd_WBaV_8yOw9jfjnlbRvV2q3af9u-AZVCZ5U</recordid><startdate>19960411</startdate><enddate>19960411</enddate><creator>Fisher, B</creator><creator>Anderson, S</creator><creator>Redmond, C K</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960411</creationdate><title>Surgery for Early Breast Cancer</title><author>Fisher, B ; Anderson, S ; Redmond, C K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-8a41d9c625bb3c0b5046d5b1bfc5d36356632065faedf68ff2fb7bca8f6282a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - surgery</topic><topic>Confidence Intervals</topic><topic>Female</topic><topic>Humans</topic><topic>Informed Consent</topic><topic>Mastectomy, Segmental</topic><topic>Medical Audit</topic><topic>Randomized Controlled Trials as Topic - standards</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fisher, B</creatorcontrib><creatorcontrib>Anderson, S</creatorcontrib><creatorcontrib>Redmond, C K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fisher, B</au><au>Anderson, S</au><au>Redmond, C K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgery for Early Breast Cancer</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1996-04-11</date><risdate>1996</risdate><volume>334</volume><issue>15</issue><spage>987</spage><epage>988</epage><pages>987-988</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
Dr. Bailar (Nov. 30 issue)
1
reassures physicians and patients that the lumpectomy study findings of the National Surgical Adjuvant Breast and Bowel Project (NSABP) are credible. However, he asserts that until a much broader analysis of the entire cohort from St. Luc Hospital alone is reported, all St. Luc data should be excluded from future interpretations of Protocol B-06. In fact, we did conduct extensive analyses to verify the integrity of the St. Luc data.
2
Presenting findings from a single institution compromises the integrity and conduct of multicenter trials. It also increases the chances of finding false . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>8596604</pmid><doi>10.1056/NEJM199604113341512</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1996-04, Vol.334 (15), p.987-988 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77956011 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Breast Neoplasms - mortality Breast Neoplasms - surgery Confidence Intervals Female Humans Informed Consent Mastectomy, Segmental Medical Audit Randomized Controlled Trials as Topic - standards Survival Analysis |
| title | Surgery for Early Breast Cancer |
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