Enantioselective Quantitation of (R)- and (S)-Alprenolol by Gas Chromatography—Mass Spectrometry in Human Saliva and Plasma

An enantioselective gas chromatographic—mass spectrometric assay is developed for alprenolol and its metabolite, 4-hydroxyalprenolol, in saliva and plasma. The procedure is based on a two-step derivatization technique with N-heptafluorobutyryl-l-prolylchloride and N-methyl-N-trimethylsilyl-trifluoro...

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