Poly(adenosine diphosphoribose) polymerase in peripheral blood leukocytes from normal donors and patients with malignancies
A two-color flow cytometric technique was developed to analyze poly(ADP-ribose) polymerase (PADPRP) in different individuals as a function of different physiological or pathological conditions and to establish the basis for determining whether enzyme deficiency may predispose to degenerative or mali...
Gespeichert in:
| Veröffentlicht in: | Clinical cancer research 1995-02, Vol.1 (2), p.223-234 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 234 |
|---|---|
| container_issue | 2 |
| container_start_page | 223 |
| container_title | Clinical cancer research |
| container_volume | 1 |
| creator | RANJIT, G. B MING-FANG CHENG MACKAY, W WHITACRE, C. M BERGER, J. S BERGER, N. A |
| description | A two-color flow cytometric technique was developed to analyze poly(ADP-ribose) polymerase (PADPRP) in different individuals
as a function of different physiological or pathological conditions and to establish the basis for determining whether enzyme
deficiency may predispose to degenerative or malignant disorders. Peripheral blood granulocytes were devoid of enzyme activity,
whereas mononuclear cells had variable amounts. PADPRP was highest in B cells, intermediate in T cells, and lowest in monocytes.
This pattern of enzyme distribution and relative enzyme content of different types of cells was remarkably constant in normal
subjects. In a series of 66 normal donors there was no significant biological variation in enzyme content as a function of
age, race, or sex. The mean PADPRP values in peripheral blood mononuclear cells from 81 random patient samples obtained from
an ambulatory oncology clinic did not differ significantly from normal subjects. However, groups of patients with breast cancer,
lymphocytic malignancies, and esophageal cancer were observed to have below normal levels for peripheral blood mononuclear
cell PADPRP. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_77952184</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77952184</sourcerecordid><originalsourceid>FETCH-LOGICAL-h266t-8a5c02597ddd8bc615a0cdec05e8f26d0512cd83126e7b572a22cd010295dcce3</originalsourceid><addsrcrecordid>eNpFkE1LxDAQhosoq67-BCEHET0UkrRp2qMsfsGCHvRc0mS6jbZJzbQsi3_eiIsewszL85BJ5iA5YULINOOFOIw9lWVK84wfJ6eI75SynNF8kSyqkolKypPk68X3u2tlwHm0DoixY-cxnmAbj3BDxsgHCAqBWEdGCFGIsSdN770hPcwfXu8mQNIGPxDnwxCh8bFBopwho5osuAnJ1k4didBunHLaAp4lR63qEc73dZm83d-9rh7T9fPD0-p2nXa8KKa0VEJTHp9rjCkbXTChqDagqYCy5YWhgnFtyozxAmQjJFc8Zsoor4TRGrJlcvV77xj85ww41YNFDX2vHPgZaykrwVmZR_FiL87NAKYegx1U2NX7bUV-uecKterb8PMP_NOygtFCsv95nd10Wxug1lGEEABBBd3VrOY151n2DUw9hM0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77952184</pqid></control><display><type>article</type><title>Poly(adenosine diphosphoribose) polymerase in peripheral blood leukocytes from normal donors and patients with malignancies</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>American Association for Cancer Research</source><source>Alma/SFX Local Collection</source><creator>RANJIT, G. B ; MING-FANG CHENG ; MACKAY, W ; WHITACRE, C. M ; BERGER, J. S ; BERGER, N. A</creator><creatorcontrib>RANJIT, G. B ; MING-FANG CHENG ; MACKAY, W ; WHITACRE, C. M ; BERGER, J. S ; BERGER, N. A</creatorcontrib><description>A two-color flow cytometric technique was developed to analyze poly(ADP-ribose) polymerase (PADPRP) in different individuals
as a function of different physiological or pathological conditions and to establish the basis for determining whether enzyme
deficiency may predispose to degenerative or malignant disorders. Peripheral blood granulocytes were devoid of enzyme activity,
whereas mononuclear cells had variable amounts. PADPRP was highest in B cells, intermediate in T cells, and lowest in monocytes.
This pattern of enzyme distribution and relative enzyme content of different types of cells was remarkably constant in normal
subjects. In a series of 66 normal donors there was no significant biological variation in enzyme content as a function of
age, race, or sex. The mean PADPRP values in peripheral blood mononuclear cells from 81 random patient samples obtained from
an ambulatory oncology clinic did not differ significantly from normal subjects. However, groups of patients with breast cancer,
lymphocytic malignancies, and esophageal cancer were observed to have below normal levels for peripheral blood mononuclear
cell PADPRP.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 9815977</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Age Factors ; Antigens, CD - immunology ; B-Lymphocytes - enzymology ; Biological and medical sciences ; Breast Neoplasms - blood ; Breast Neoplasms - enzymology ; Child ; Esophageal Neoplasms - blood ; Esophageal Neoplasms - enzymology ; Female ; Flow Cytometry ; General aspects ; Granulocytes - enzymology ; Humans ; Leukocytes - enzymology ; Leukocytes - immunology ; Lymphoma - blood ; Lymphoma - enzymology ; Male ; Medical sciences ; Monocytes - enzymology ; Neoplasms - blood ; Neoplasms - enzymology ; Poly(ADP-ribose) Polymerases - blood ; Reference Values ; Regression Analysis ; T-Lymphocytes - enzymology ; Tumors</subject><ispartof>Clinical cancer research, 1995-02, Vol.1 (2), p.223-234</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3610671$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9815977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RANJIT, G. B</creatorcontrib><creatorcontrib>MING-FANG CHENG</creatorcontrib><creatorcontrib>MACKAY, W</creatorcontrib><creatorcontrib>WHITACRE, C. M</creatorcontrib><creatorcontrib>BERGER, J. S</creatorcontrib><creatorcontrib>BERGER, N. A</creatorcontrib><title>Poly(adenosine diphosphoribose) polymerase in peripheral blood leukocytes from normal donors and patients with malignancies</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>A two-color flow cytometric technique was developed to analyze poly(ADP-ribose) polymerase (PADPRP) in different individuals
as a function of different physiological or pathological conditions and to establish the basis for determining whether enzyme
deficiency may predispose to degenerative or malignant disorders. Peripheral blood granulocytes were devoid of enzyme activity,
whereas mononuclear cells had variable amounts. PADPRP was highest in B cells, intermediate in T cells, and lowest in monocytes.
This pattern of enzyme distribution and relative enzyme content of different types of cells was remarkably constant in normal
subjects. In a series of 66 normal donors there was no significant biological variation in enzyme content as a function of
age, race, or sex. The mean PADPRP values in peripheral blood mononuclear cells from 81 random patient samples obtained from
an ambulatory oncology clinic did not differ significantly from normal subjects. However, groups of patients with breast cancer,
lymphocytic malignancies, and esophageal cancer were observed to have below normal levels for peripheral blood mononuclear
cell PADPRP.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Antigens, CD - immunology</subject><subject>B-Lymphocytes - enzymology</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - enzymology</subject><subject>Child</subject><subject>Esophageal Neoplasms - blood</subject><subject>Esophageal Neoplasms - enzymology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>General aspects</subject><subject>Granulocytes - enzymology</subject><subject>Humans</subject><subject>Leukocytes - enzymology</subject><subject>Leukocytes - immunology</subject><subject>Lymphoma - blood</subject><subject>Lymphoma - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monocytes - enzymology</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - enzymology</subject><subject>Poly(ADP-ribose) Polymerases - blood</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>T-Lymphocytes - enzymology</subject><subject>Tumors</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhosoq67-BCEHET0UkrRp2qMsfsGCHvRc0mS6jbZJzbQsi3_eiIsewszL85BJ5iA5YULINOOFOIw9lWVK84wfJ6eI75SynNF8kSyqkolKypPk68X3u2tlwHm0DoixY-cxnmAbj3BDxsgHCAqBWEdGCFGIsSdN770hPcwfXu8mQNIGPxDnwxCh8bFBopwho5osuAnJ1k4didBunHLaAp4lR63qEc73dZm83d-9rh7T9fPD0-p2nXa8KKa0VEJTHp9rjCkbXTChqDagqYCy5YWhgnFtyozxAmQjJFc8Zsoor4TRGrJlcvV77xj85ww41YNFDX2vHPgZaykrwVmZR_FiL87NAKYegx1U2NX7bUV-uecKterb8PMP_NOygtFCsv95nd10Wxug1lGEEABBBd3VrOY151n2DUw9hM0</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>RANJIT, G. B</creator><creator>MING-FANG CHENG</creator><creator>MACKAY, W</creator><creator>WHITACRE, C. M</creator><creator>BERGER, J. S</creator><creator>BERGER, N. A</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19950201</creationdate><title>Poly(adenosine diphosphoribose) polymerase in peripheral blood leukocytes from normal donors and patients with malignancies</title><author>RANJIT, G. B ; MING-FANG CHENG ; MACKAY, W ; WHITACRE, C. M ; BERGER, J. S ; BERGER, N. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-8a5c02597ddd8bc615a0cdec05e8f26d0512cd83126e7b572a22cd010295dcce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Antigens, CD - immunology</topic><topic>B-Lymphocytes - enzymology</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - enzymology</topic><topic>Child</topic><topic>Esophageal Neoplasms - blood</topic><topic>Esophageal Neoplasms - enzymology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>General aspects</topic><topic>Granulocytes - enzymology</topic><topic>Humans</topic><topic>Leukocytes - enzymology</topic><topic>Leukocytes - immunology</topic><topic>Lymphoma - blood</topic><topic>Lymphoma - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monocytes - enzymology</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - enzymology</topic><topic>Poly(ADP-ribose) Polymerases - blood</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>T-Lymphocytes - enzymology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RANJIT, G. B</creatorcontrib><creatorcontrib>MING-FANG CHENG</creatorcontrib><creatorcontrib>MACKAY, W</creatorcontrib><creatorcontrib>WHITACRE, C. M</creatorcontrib><creatorcontrib>BERGER, J. S</creatorcontrib><creatorcontrib>BERGER, N. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RANJIT, G. B</au><au>MING-FANG CHENG</au><au>MACKAY, W</au><au>WHITACRE, C. M</au><au>BERGER, J. S</au><au>BERGER, N. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poly(adenosine diphosphoribose) polymerase in peripheral blood leukocytes from normal donors and patients with malignancies</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>1</volume><issue>2</issue><spage>223</spage><epage>234</epage><pages>223-234</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>A two-color flow cytometric technique was developed to analyze poly(ADP-ribose) polymerase (PADPRP) in different individuals
as a function of different physiological or pathological conditions and to establish the basis for determining whether enzyme
deficiency may predispose to degenerative or malignant disorders. Peripheral blood granulocytes were devoid of enzyme activity,
whereas mononuclear cells had variable amounts. PADPRP was highest in B cells, intermediate in T cells, and lowest in monocytes.
This pattern of enzyme distribution and relative enzyme content of different types of cells was remarkably constant in normal
subjects. In a series of 66 normal donors there was no significant biological variation in enzyme content as a function of
age, race, or sex. The mean PADPRP values in peripheral blood mononuclear cells from 81 random patient samples obtained from
an ambulatory oncology clinic did not differ significantly from normal subjects. However, groups of patients with breast cancer,
lymphocytic malignancies, and esophageal cancer were observed to have below normal levels for peripheral blood mononuclear
cell PADPRP.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>9815977</pmid><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 1995-02, Vol.1 (2), p.223-234 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77952184 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research; Alma/SFX Local Collection |
| subjects | Adult Age Factors Antigens, CD - immunology B-Lymphocytes - enzymology Biological and medical sciences Breast Neoplasms - blood Breast Neoplasms - enzymology Child Esophageal Neoplasms - blood Esophageal Neoplasms - enzymology Female Flow Cytometry General aspects Granulocytes - enzymology Humans Leukocytes - enzymology Leukocytes - immunology Lymphoma - blood Lymphoma - enzymology Male Medical sciences Monocytes - enzymology Neoplasms - blood Neoplasms - enzymology Poly(ADP-ribose) Polymerases - blood Reference Values Regression Analysis T-Lymphocytes - enzymology Tumors |
| title | Poly(adenosine diphosphoribose) polymerase in peripheral blood leukocytes from normal donors and patients with malignancies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T02%3A59%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Poly(adenosine%20diphosphoribose)%20polymerase%20in%20peripheral%20blood%20leukocytes%20from%20normal%20donors%20and%20patients%20with%20malignancies&rft.jtitle=Clinical%20cancer%20research&rft.au=RANJIT,%20G.%20B&rft.date=1995-02-01&rft.volume=1&rft.issue=2&rft.spage=223&rft.epage=234&rft.pages=223-234&rft.issn=1078-0432&rft.eissn=1557-3265&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E77952184%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77952184&rft_id=info:pmid/9815977&rfr_iscdi=true |