Renal resistive index in experimental partial and complete ureteral obstruction
Recent clinical work suggests that the Doppler resistive index (RI) may be useful in distinguishing obstructive from nonobstructive hydronephrosis. We evaluated the usefulness of the RI in a rabbit model of hydronephrosis. Unilateral partial ureteral obstruction was produced in nine rabbits and comp...
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| Veröffentlicht in: | Academic radiology 1995-05, Vol.2 (5), p.373-378 |
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| creator | Coley, Brian D. Arellano, Ronald S. Talner, Lee B. Baker, Kristine G. Peterson, Tom Mattrey, Robert F. |
| description | Recent clinical work suggests that the Doppler resistive index (RI) may be useful in distinguishing obstructive from nonobstructive hydronephrosis. We evaluated the usefulness of the RI in a rabbit model of hydronephrosis.
Unilateral partial ureteral obstruction was produced in nine rabbits and complete obstruction in another nine. Three sham operations were performed, and these animals served as control subjects. The RI was measured in all kidneys before and 6 hr after surgery and on days 1, 4, and 7 postoperatively. The RI and the difference in RI (ΔRI) between the obstructed and normal kidney were evaluated over time using a two-way analysis of variance. The intravenous urography and Whitaker tests served as gold standards.
Hydronephrosis was observed on sonograms in all obstructed kidneys. Comparing groups, there was no significant difference in mean RI or ΔRI between the three groups at any time point. Looking at individual groups over time, there was no significant change in mean ΔRI, whereas the change in mean RI was significantly elevated above baseline only in the complete obstruction group at 6 hr (
p = .002) and on days 4 (
p = .008) and 7 (
p = .006). In evaluating varying thresholds of RI and ΔRI, we could not consistently discriminate between normal and obstructed kidneys.
Although complete obstruction caused a significant increase in RI, partial obstruction failed to do so. RI and ΔRI values proved to be insensitive predictors of obstruction in this rabbit model. |
| doi_str_mv | 10.1016/S1076-6332(05)80337-X |
| format | Article |
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Unilateral partial ureteral obstruction was produced in nine rabbits and complete obstruction in another nine. Three sham operations were performed, and these animals served as control subjects. The RI was measured in all kidneys before and 6 hr after surgery and on days 1, 4, and 7 postoperatively. The RI and the difference in RI (ΔRI) between the obstructed and normal kidney were evaluated over time using a two-way analysis of variance. The intravenous urography and Whitaker tests served as gold standards.
Hydronephrosis was observed on sonograms in all obstructed kidneys. Comparing groups, there was no significant difference in mean RI or ΔRI between the three groups at any time point. Looking at individual groups over time, there was no significant change in mean ΔRI, whereas the change in mean RI was significantly elevated above baseline only in the complete obstruction group at 6 hr (
p = .002) and on days 4 (
p = .008) and 7 (
p = .006). In evaluating varying thresholds of RI and ΔRI, we could not consistently discriminate between normal and obstructed kidneys.
Although complete obstruction caused a significant increase in RI, partial obstruction failed to do so. RI and ΔRI values proved to be insensitive predictors of obstruction in this rabbit model.</description><identifier>ISSN: 1076-6332</identifier><identifier>EISSN: 1878-4046</identifier><identifier>DOI: 10.1016/S1076-6332(05)80337-X</identifier><identifier>PMID: 9419578</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Analysis of Variance ; Animals ; Disease Models, Animal ; Doppler ultrasound ; Hydronephrosis - diagnosis ; Hydronephrosis - etiology ; Hydronephrosis - physiopathology ; Kidney - blood supply ; Kidney - diagnostic imaging ; Kidney Pelvis - diagnostic imaging ; Kidney Pelvis - physiopathology ; obstructive hydronephrosis ; Pressure ; Rabbits ; Renal Artery - diagnostic imaging ; Renal Artery - physiology ; Renal Circulation ; renal dilatation ; Resistive index ; Sensitivity and Specificity ; Ultrasonography, Doppler, Color ; Ureteral Obstruction - complications ; Ureteral Obstruction - diagnosis ; Ureteral Obstruction - physiopathology ; Urography ; Vascular Resistance</subject><ispartof>Academic radiology, 1995-05, Vol.2 (5), p.373-378</ispartof><rights>1995 Association of University Radiologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-d19364d3e951e662fd0e68cd9a05e5e67c6da00ccb1d0fc7a22e2654f05962f93</citedby><cites>FETCH-LOGICAL-c360t-d19364d3e951e662fd0e68cd9a05e5e67c6da00ccb1d0fc7a22e2654f05962f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S107663320580337X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9419578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coley, Brian D.</creatorcontrib><creatorcontrib>Arellano, Ronald S.</creatorcontrib><creatorcontrib>Talner, Lee B.</creatorcontrib><creatorcontrib>Baker, Kristine G.</creatorcontrib><creatorcontrib>Peterson, Tom</creatorcontrib><creatorcontrib>Mattrey, Robert F.</creatorcontrib><title>Renal resistive index in experimental partial and complete ureteral obstruction</title><title>Academic radiology</title><addtitle>Acad Radiol</addtitle><description>Recent clinical work suggests that the Doppler resistive index (RI) may be useful in distinguishing obstructive from nonobstructive hydronephrosis. We evaluated the usefulness of the RI in a rabbit model of hydronephrosis.
Unilateral partial ureteral obstruction was produced in nine rabbits and complete obstruction in another nine. Three sham operations were performed, and these animals served as control subjects. The RI was measured in all kidneys before and 6 hr after surgery and on days 1, 4, and 7 postoperatively. The RI and the difference in RI (ΔRI) between the obstructed and normal kidney were evaluated over time using a two-way analysis of variance. The intravenous urography and Whitaker tests served as gold standards.
Hydronephrosis was observed on sonograms in all obstructed kidneys. Comparing groups, there was no significant difference in mean RI or ΔRI between the three groups at any time point. Looking at individual groups over time, there was no significant change in mean ΔRI, whereas the change in mean RI was significantly elevated above baseline only in the complete obstruction group at 6 hr (
p = .002) and on days 4 (
p = .008) and 7 (
p = .006). In evaluating varying thresholds of RI and ΔRI, we could not consistently discriminate between normal and obstructed kidneys.
Although complete obstruction caused a significant increase in RI, partial obstruction failed to do so. RI and ΔRI values proved to be insensitive predictors of obstruction in this rabbit model.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Doppler ultrasound</subject><subject>Hydronephrosis - diagnosis</subject><subject>Hydronephrosis - etiology</subject><subject>Hydronephrosis - physiopathology</subject><subject>Kidney - blood supply</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney Pelvis - diagnostic imaging</subject><subject>Kidney Pelvis - physiopathology</subject><subject>obstructive hydronephrosis</subject><subject>Pressure</subject><subject>Rabbits</subject><subject>Renal Artery - diagnostic imaging</subject><subject>Renal Artery - physiology</subject><subject>Renal Circulation</subject><subject>renal dilatation</subject><subject>Resistive index</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography, Doppler, Color</subject><subject>Ureteral Obstruction - complications</subject><subject>Ureteral Obstruction - diagnosis</subject><subject>Ureteral Obstruction - physiopathology</subject><subject>Urography</subject><subject>Vascular Resistance</subject><issn>1076-6332</issn><issn>1878-4046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78hIWeRA_VSdOkzUlE_IKFBT_AW8gmU4h025qksv574-7q1cvMMO87M8xDyJTCBQUqLp8pVCIXjBVnwM9rYKzK33bIhNZVnZdQit1U_1oOyGEI7wCUi5rtk31ZUsmrekLmT9jpNvMYXIjuEzPXWVylmOFqQO-W2MWkD9pHl7LubGb65dBixGz0KfrU7Rch-tFE13fHZK_RbcCTbT4ir3e3LzcP-Wx-_3hzPcsNExBzSyUTpWUoOUUhisYCitpYqYEjR1EZYTWAMQtqoTGVLgosBC8b4DK5JTsip5u9g-8_RgxRLV0w2La6w34MqqokL0BCMvKN0fg-BI-NGtJX2n8pCuoHpFqDVD-UFHC1Bqne0tx0e2BcLNH-TW3JJf1qo2P68tOhV8E47Axa59FEZXv3z4Vv4VSERA</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>Coley, Brian D.</creator><creator>Arellano, Ronald S.</creator><creator>Talner, Lee B.</creator><creator>Baker, Kristine G.</creator><creator>Peterson, Tom</creator><creator>Mattrey, Robert F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950501</creationdate><title>Renal resistive index in experimental partial and complete ureteral obstruction</title><author>Coley, Brian D. ; Arellano, Ronald S. ; Talner, Lee B. ; Baker, Kristine G. ; Peterson, Tom ; Mattrey, Robert F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-d19364d3e951e662fd0e68cd9a05e5e67c6da00ccb1d0fc7a22e2654f05962f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Doppler ultrasound</topic><topic>Hydronephrosis - diagnosis</topic><topic>Hydronephrosis - etiology</topic><topic>Hydronephrosis - physiopathology</topic><topic>Kidney - blood supply</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney Pelvis - diagnostic imaging</topic><topic>Kidney Pelvis - physiopathology</topic><topic>obstructive hydronephrosis</topic><topic>Pressure</topic><topic>Rabbits</topic><topic>Renal Artery - diagnostic imaging</topic><topic>Renal Artery - physiology</topic><topic>Renal Circulation</topic><topic>renal dilatation</topic><topic>Resistive index</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography, Doppler, Color</topic><topic>Ureteral Obstruction - complications</topic><topic>Ureteral Obstruction - diagnosis</topic><topic>Ureteral Obstruction - physiopathology</topic><topic>Urography</topic><topic>Vascular Resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coley, Brian D.</creatorcontrib><creatorcontrib>Arellano, Ronald S.</creatorcontrib><creatorcontrib>Talner, Lee B.</creatorcontrib><creatorcontrib>Baker, Kristine G.</creatorcontrib><creatorcontrib>Peterson, Tom</creatorcontrib><creatorcontrib>Mattrey, Robert F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Academic radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coley, Brian D.</au><au>Arellano, Ronald S.</au><au>Talner, Lee B.</au><au>Baker, Kristine G.</au><au>Peterson, Tom</au><au>Mattrey, Robert F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal resistive index in experimental partial and complete ureteral obstruction</atitle><jtitle>Academic radiology</jtitle><addtitle>Acad Radiol</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>2</volume><issue>5</issue><spage>373</spage><epage>378</epage><pages>373-378</pages><issn>1076-6332</issn><eissn>1878-4046</eissn><abstract>Recent clinical work suggests that the Doppler resistive index (RI) may be useful in distinguishing obstructive from nonobstructive hydronephrosis. We evaluated the usefulness of the RI in a rabbit model of hydronephrosis.
Unilateral partial ureteral obstruction was produced in nine rabbits and complete obstruction in another nine. Three sham operations were performed, and these animals served as control subjects. The RI was measured in all kidneys before and 6 hr after surgery and on days 1, 4, and 7 postoperatively. The RI and the difference in RI (ΔRI) between the obstructed and normal kidney were evaluated over time using a two-way analysis of variance. The intravenous urography and Whitaker tests served as gold standards.
Hydronephrosis was observed on sonograms in all obstructed kidneys. Comparing groups, there was no significant difference in mean RI or ΔRI between the three groups at any time point. Looking at individual groups over time, there was no significant change in mean ΔRI, whereas the change in mean RI was significantly elevated above baseline only in the complete obstruction group at 6 hr (
p = .002) and on days 4 (
p = .008) and 7 (
p = .006). In evaluating varying thresholds of RI and ΔRI, we could not consistently discriminate between normal and obstructed kidneys.
Although complete obstruction caused a significant increase in RI, partial obstruction failed to do so. RI and ΔRI values proved to be insensitive predictors of obstruction in this rabbit model.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9419578</pmid><doi>10.1016/S1076-6332(05)80337-X</doi><tpages>6</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Disease Models, Animal Doppler ultrasound Hydronephrosis - diagnosis Hydronephrosis - etiology Hydronephrosis - physiopathology Kidney - blood supply Kidney - diagnostic imaging Kidney Pelvis - diagnostic imaging Kidney Pelvis - physiopathology obstructive hydronephrosis Pressure Rabbits Renal Artery - diagnostic imaging Renal Artery - physiology Renal Circulation renal dilatation Resistive index Sensitivity and Specificity Ultrasonography, Doppler, Color Ureteral Obstruction - complications Ureteral Obstruction - diagnosis Ureteral Obstruction - physiopathology Urography Vascular Resistance |
| title | Renal resistive index in experimental partial and complete ureteral obstruction |
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