Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease

Tiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [ 3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with...

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Veröffentlicht in:	Life sciences (1973) 1995, Vol.56 (11), p.853-859
Hauptverfasser:	Barnes, Peter J, Belvisi, Maria G, Mak, Judith C.W., Haddad, El-Bdaoui, O'Connor, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism airways Animals anticholinergics asthma Bronchodilator Agents - chemistry Bronchodilator Agents - metabolism Bronchodilator Agents - therapeutic use Chronic Disease chronic obstructive pulmonary disease Guinea Pigs Humans Ipratropium - chemistry Ipratropium - metabolism Ipratropium - therapeutic use Lung - drug effects Lung - metabolism Lung Diseases, Obstructive - drug therapy Lung Diseases, Obstructive - metabolism Muscarinic Antagonists - chemistry Muscarinic Antagonists - metabolism Muscarinic Antagonists - therapeutic use muscarinic receptors Receptors, Muscarinic - metabolism Scopolamine Derivatives - chemistry Scopolamine Derivatives - metabolism Scopolamine Derivatives - therapeutic use Tiotropium Bromide
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