Transient immunomodulation by intravenous methylprednisolone treatment of multiple sclerosis

The extent and duration of immunomodulation induced by high-dose corticosteroid treatment of clinical relapse of multiple sclerosis was investigated. Ten patients treated with a 5 day course of intravenous methylprednisolone (IVMP) (500 mg daily) were studied. Circulating lymphocyte subpopulations a...

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Veröffentlicht in:	Multiple sclerosis 1995-04, Vol.1 (1), p.20-24
Hauptverfasser:	Crockard, AD, Treacy, MT, Droogan, AG, McNeill, TA, Hawkins, SA
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - therapeutic use Adult Antigens, CD - drug effects Antigens, CD - metabolism Female Glucocorticoids - therapeutic use HLA-DR Antigens - biosynthesis HLA-DR Antigens - drug effects Humans Injections, Intravenous Interferon-gamma - biosynthesis Interferon-gamma - drug effects Interleukin-2 - biosynthesis Lymphocyte Count - drug effects Lymphocyte Subsets - drug effects Lymphocyte Subsets - immunology Male Methylprednisolone - administration & dosage Methylprednisolone - therapeutic use Middle Aged Mitogens - pharmacology Multiple Sclerosis - drug therapy Multiple Sclerosis - immunology Receptors, Antigen, T-Cell, alpha-beta - drug effects Receptors, Antigen, T-Cell, alpha-beta - metabolism Receptors, Antigen, T-Cell, gamma-delta - drug effects Receptors, Antigen, T-Cell, gamma-delta - metabolism Time Factors
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