Tests for Distributed, Nonfocal Brain Activations

Most approaches to detecting changes in functional brain images assume that activations are focal or very localized. However, the brain's response to cognitive of sensorimotor challenge may be spatially or anatomically distributed. In this paper we consider the use-fulness of a test based on th...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 1995-09, Vol.2 (3), p.183-194
Hauptverfasser: Worsley, K.J., Poline, J-B., Vandal, A.C., Friston, K.J.
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container_start_page 183
container_title NeuroImage (Orlando, Fla.)
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creator Worsley, K.J.
Poline, J-B.
Vandal, A.C.
Friston, K.J.
description Most approaches to detecting changes in functional brain images assume that activations are focal or very localized. However, the brain's response to cognitive of sensorimotor challenge may be spatially or anatomically distributed. In this paper we consider the use-fulness of a test based on the mean sum of squares of statistical parametric maps. The performance of this test is evaluated using simulated and real data and is compared to the γ 2 test, a test of the size of the activated region, and a focal activation test based on the intensity of local maxima. We demonstrate that the mean sum of squares test is more sensitive to nonfocal signals and propose that it could be used to complement approaches that are more sensitive to focal activations.
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subjects Arousal - physiology
Attention - physiology
Brain - physiology
Brain Mapping
Fourier Analysis
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging - statistics & numerical data
Mathematical Computing
Normal Distribution
Phantoms, Imaging
Tomography, Emission-Computed - statistics & numerical data
title Tests for Distributed, Nonfocal Brain Activations
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