Influence of frusemide on cis-dichlorodiammineplatinum (II) pharmaco-kinetics

Cis-dichlorodiammineplatinum (CDDP) pharmacokinetics were evaluated in eighteen patients with cancer who received 80 mg/m2 CDDP as a 20 min infusion. One hour before, 10 of them had 20 mg/m2 frusemide. Fifteen blood samples and fifteen urine samples were collected over the 5 hours following the infu...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 1987-07, Vol.12 (3), p.203-206
Hauptverfasser:	DUMAS, M, D'ATHIS, P, DE GISLAIN, C, LAUTISSIER, J. L, AUTISSIER, N, ESCOUSSE, A, GUERRIN, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cisplatin - pharmacokinetics Furosemide - pharmacology General aspects Humans Kidney Diseases - metabolism Medical sciences Pharmacology. Drug treatments Platinum - blood Platinum - urine Spectrophotometry, Atomic
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