Physicochemical properties, pharmacokinetics, and biodistribution of gadoteridol injection in rats and dogs

The physicochemical properties of gadoteridol, a macrocyclic nonionic gadolinium complex, were studied together with its pharmacokinetics and biodistribution in rats and dogs. Studies in rats were conducted after single intravenous injections at 0.1 or 0.35 mmol/kg using 153Gd-labeled gadoteridol or...

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Veröffentlicht in:	Academic radiology 1995-07, Vol.2 (7), p.584-591
Hauptverfasser:	Eakins, Michael N., Eaton, Stephen M., Fisco, Ricardo A., Hunt, Richard J., Ita, Callixtus E., Katona, Thomas, Owies, Laila M., Schramm, Ernst, Sulner, Joseph W., Thompson, Charles W., White, Gregory W., Murthy Yerramilli, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal pharmacokinetics Animals Autoradiography Bone and Bones - metabolism Contrast Media - administration & dosage Contrast Media - chemistry Contrast Media - pharmacokinetics Dogs - metabolism Female gadolinium Gadolinium - pharmacokinetics gadoteridol Heterocyclic Compounds - administration & dosage Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacokinetics Injections, Intravenous Liver - metabolism Magnetic resonance contrast agents Male Organometallic Compounds - administration & dosage Organometallic Compounds - chemistry Organometallic Compounds - pharmacokinetics Osmolar Concentration physicochemical properties Radioisotopes Rats Rats, Sprague-Dawley - metabolism Tissue Distribution Viscosity
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