Synthesis of Peptide Chloromethyl Ketones and Examination of Their Inhibitory Effects on Human Spleen Fibrinolytic Proteinase (SFP) and Human Leukocyte Elastase (LE)

Various substrate-derived chloromethyl ketones were synthesized by a conventional method for the purpose of obtaining specific and potent irreversible inhibitors for human spleen fibrinolytic proteinase (SFP) and human leukocyte elastase (LE) in order to compare the properties of SFP with those of L...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1987/09/25, Vol.35(9), pp.3576-3584
Hauptverfasser:	TSUDA, YUKO, OKADA, YOSHIO, NAGAMATSU, YOKO, OKAMOTO, UTAKO
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - chemical synthesis chemical synthesis Chemistry chloromethyl ketones Endopeptidases Exact sciences and technology human leukocyte elastase human spleen fibrinolytic proteinase Humans In Vitro Techniques leukocyte elastase Leukocytes - enzymology man Organic chemistry Pancreatic Elastase - antagonists & inhibitors peptide chloromethyl ketone peptide synthesis Peptides Preparations and properties Protease Inhibitors specific inhibition Spleen - enzymology spleen fibrinolytic proteinase
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