Penetration of ofloxacin from blood to sputum

Penetration of ofloxacin from blood to sputum

Serum and sputum concentrations of ofloxacin were measured by a microbiological agar-well diffusion assay in nearly 100 patients after single 400, 600 or 800 mg doses of ofloxacin. All patients were admitted to hospital because of acute purulent exacerbations of chronic respiratory disease, and the...

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Veröffentlicht in:Drugs (New York, N.Y.) N.Y.), 1987, Vol.34 Suppl 1 (Supplement 1), p.26-32
Hauptverfasser: Davies, B I, Maesen, F P, Geraedts, W H, Baur, C
Format: Artikel
Sprache:eng
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Anti-Infective Agents - blood
Anti-Infective Agents - pharmacokinetics
Humans
Ofloxacin
Oxazines - blood
Oxazines - pharmacokinetics
Sputum - metabolism
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container_end_page 32
container_issue Supplement 1
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container_title Drugs (New York, N.Y.)
container_volume 34 Suppl 1
creator Davies, B I
Maesen, F P
Geraedts, W H
Baur, C
description Serum and sputum concentrations of ofloxacin were measured by a microbiological agar-well diffusion assay in nearly 100 patients after single 400, 600 or 800 mg doses of ofloxacin. All patients were admitted to hospital because of acute purulent exacerbations of chronic respiratory disease, and the concentration studies were performed on the first treatment day while the sputum was still purulent. Both blood and sputum samples were tested at standardised time intervals after dosage, and concentration-time curves were constructed. Cmax values in serum and sputum were 3.7 and 2.7 mg/L after 400 mg ofloxacin, 7.1 and 6.1 mg/L after 600 mg and 8.8 and 6.3 mg/L after 800 mg. Penetration from blood to sputum, as judged from ratio of AUC values for sputum and serum, varied from 78 to 103%.
doi_str_mv 10.2165/00003495-198700341-00007
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subjects Anti-Infective Agents - blood
Anti-Infective Agents - pharmacokinetics
Humans
Ofloxacin
Oxazines - blood
Oxazines - pharmacokinetics
Sputum - metabolism
title Penetration of ofloxacin from blood to sputum
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