Scanning electron microscope analysis of structural changes and aberrations in human chromosomes associated with the inhibition and reversal of inhibition of ultraviolet light induced DNA repair

Metaphase chromosomes appear decondensed in preparations from mitotic cells that have been irradiated with ultraviolet light (UV) and incubated with inhibitors of DNA synthesis; under these conditions DNA repair is inhibited and both single and double strand DNA breaks accumulate. After reversal of...

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Veröffentlicht in:	Chromosoma 1987-01, Vol.96 (1), p.39-44
Hauptverfasser:	MULLINGER, A. M, JOHNSON, R. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosome Aberrations Chromosomes, Human - radiation effects Chromosomes, Human - ultrastructure DNA Damage DNA Repair - radiation effects Fundamental and applied biological sciences. Psychology HeLa Cells - metabolism HeLa Cells - radiation effects HeLa Cells - ultrastructure Humans Metaphase Microscopy, Electron, Scanning Molecular and cellular biology Molecular genetics Mutagenesis. Repair
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