Nifedipine is an antagonist to cyclotron resonance enhancement of 45Ca incorporation in human lymphocytes
The incorporation of 45Ca in mixed human lymphocytes was measured following one-hour exposures of the cells to combined steady and periodic magnetic fields designed to probe for cyclotron resonance response in calcium incorporation. Measurements were made as a function of magnetic field frequency, u...
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| Veröffentlicht in: | Cell calcium (Edinburgh) 1987-12, Vol.8 (6), p.413-427 |
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| container_issue | 6 |
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| container_title | Cell calcium (Edinburgh) |
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| creator | Rozek, R.J. Sherman, M.L. Liboff, A.R. McLeod, B.R. Smith, S.D. |
| description | The incorporation of
45Ca in mixed human lymphocytes was measured following one-hour exposures of the cells to combined steady and periodic magnetic fields designed to probe for cyclotron resonance response in calcium incorporation. Measurements were made as a function of magnetic field frequency, up to 30 Hz, and as a function of magnetic field amplitude, up to 1.5 × 10
−4 T
rms. The amplitude measurements demonstrated that the relative
45Ca uptake at resonance follows different mechanisms of interaction above and below 0.2 × 10
−4 T
rms. After adjusting the magnetic field configuration for maximum incorporation, we then determined the effects of the calcium influx blocker nifedipine on
45Ca incorporation, with and without simultaneous exposure to this specific magnetic field combination. The presence of nifedipine in both unexposed and exposed cell suspensions resulted in decreased
45Ca uptake, presumably through the slow inward calcium channels. Evidence was found suggesting that nifedipine acts antagonistially to the
45Ca cyclotron resonance tuning signal. |
| doi_str_mv | 10.1016/0143-4160(87)90025-X |
| format | Article |
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45Ca in mixed human lymphocytes was measured following one-hour exposures of the cells to combined steady and periodic magnetic fields designed to probe for cyclotron resonance response in calcium incorporation. Measurements were made as a function of magnetic field frequency, up to 30 Hz, and as a function of magnetic field amplitude, up to 1.5 × 10
−4 T
rms. The amplitude measurements demonstrated that the relative
45Ca uptake at resonance follows different mechanisms of interaction above and below 0.2 × 10
−4 T
rms. After adjusting the magnetic field configuration for maximum incorporation, we then determined the effects of the calcium influx blocker nifedipine on
45Ca incorporation, with and without simultaneous exposure to this specific magnetic field combination. The presence of nifedipine in both unexposed and exposed cell suspensions resulted in decreased
45Ca uptake, presumably through the slow inward calcium channels. Evidence was found suggesting that nifedipine acts antagonistially to the
45Ca cyclotron resonance tuning signal.</description><identifier>ISSN: 0143-4160</identifier><identifier>EISSN: 1532-1991</identifier><identifier>DOI: 10.1016/0143-4160(87)90025-X</identifier><identifier>PMID: 3435912</identifier><identifier>CODEN: CECADV</identifier><language>eng</language><publisher>Oxford: Elsevier India Pvt Ltd</publisher><subject>Biological and medical sciences ; Calcium - blood ; Calcium Radioisotopes ; Cell physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Lymphocytes - metabolism ; Membrane and intracellular transports ; Molecular and cellular biology ; Nifedipine - pharmacology ; Particle Accelerators</subject><ispartof>Cell calcium (Edinburgh), 1987-12, Vol.8 (6), p.413-427</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2842-59e91adbccad8e55b25c990126e76e076649b269b18cfc71fd4eef1e0c1dcae43</citedby><cites>FETCH-LOGICAL-c2842-59e91adbccad8e55b25c990126e76e076649b269b18cfc71fd4eef1e0c1dcae43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/014341608790025X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7625057$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3435912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rozek, R.J.</creatorcontrib><creatorcontrib>Sherman, M.L.</creatorcontrib><creatorcontrib>Liboff, A.R.</creatorcontrib><creatorcontrib>McLeod, B.R.</creatorcontrib><creatorcontrib>Smith, S.D.</creatorcontrib><title>Nifedipine is an antagonist to cyclotron resonance enhancement of 45Ca incorporation in human lymphocytes</title><title>Cell calcium (Edinburgh)</title><addtitle>Cell Calcium</addtitle><description>The incorporation of
45Ca in mixed human lymphocytes was measured following one-hour exposures of the cells to combined steady and periodic magnetic fields designed to probe for cyclotron resonance response in calcium incorporation. Measurements were made as a function of magnetic field frequency, up to 30 Hz, and as a function of magnetic field amplitude, up to 1.5 × 10
−4 T
rms. The amplitude measurements demonstrated that the relative
45Ca uptake at resonance follows different mechanisms of interaction above and below 0.2 × 10
−4 T
rms. After adjusting the magnetic field configuration for maximum incorporation, we then determined the effects of the calcium influx blocker nifedipine on
45Ca incorporation, with and without simultaneous exposure to this specific magnetic field combination. The presence of nifedipine in both unexposed and exposed cell suspensions resulted in decreased
45Ca uptake, presumably through the slow inward calcium channels. Evidence was found suggesting that nifedipine acts antagonistially to the
45Ca cyclotron resonance tuning signal.</description><subject>Biological and medical sciences</subject><subject>Calcium - blood</subject><subject>Calcium Radioisotopes</subject><subject>Cell physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lymphocytes - metabolism</subject><subject>Membrane and intracellular transports</subject><subject>Molecular and cellular biology</subject><subject>Nifedipine - pharmacology</subject><subject>Particle Accelerators</subject><issn>0143-4160</issn><issn>1532-1991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo6-zqP1DIQWQ9tCbppNO5LMjgFyx6UdhbSFdXO5HupE0ywvx7M84wR6GgDvW8L8VDyAvO3nLGu3eMy7aRvGO3vX5jGBOqeXhENly1ouHG8Mdkc0GekuucfzHGTKv5FblqZasMFxviv_oJR7_6gNRn6kKd4n7G4HOhJVI4wBxLioEmzDG4AEgx7I57wVBonKhUW0d9gJjWmFzxlfWB7vZLLZsPy7qLcCiYn5Enk5szPj_vG_Lj44fv28_N_bdPX7bv7xsQvRSNMmi4GwcAN_ao1CAUGMO46FB3yHTXSTOIzgy8hwk0n0aJOHFkwEdwKNsb8vrUu6b4e4-52MVnwHl2AeM-W61N2xkhKihPIKSYc8LJrskvLh0sZ_Zo2B712aM-22v7z7B9qLGX5_79sOB4CZ2V1vur891lcPOUqiufL5juhGJKV-zuhGF18cdjshk8Vq2jTwjFjtH__4-_fxiZTQ</recordid><startdate>198712</startdate><enddate>198712</enddate><creator>Rozek, R.J.</creator><creator>Sherman, M.L.</creator><creator>Liboff, A.R.</creator><creator>McLeod, B.R.</creator><creator>Smith, S.D.</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198712</creationdate><title>Nifedipine is an antagonist to cyclotron resonance enhancement of 45Ca incorporation in human lymphocytes</title><author>Rozek, R.J. ; Sherman, M.L. ; Liboff, A.R. ; McLeod, B.R. ; Smith, S.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2842-59e91adbccad8e55b25c990126e76e076649b269b18cfc71fd4eef1e0c1dcae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Biological and medical sciences</topic><topic>Calcium - blood</topic><topic>Calcium Radioisotopes</topic><topic>Cell physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lymphocytes - metabolism</topic><topic>Membrane and intracellular transports</topic><topic>Molecular and cellular biology</topic><topic>Nifedipine - pharmacology</topic><topic>Particle Accelerators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rozek, R.J.</creatorcontrib><creatorcontrib>Sherman, M.L.</creatorcontrib><creatorcontrib>Liboff, A.R.</creatorcontrib><creatorcontrib>McLeod, B.R.</creatorcontrib><creatorcontrib>Smith, S.D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell calcium (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rozek, R.J.</au><au>Sherman, M.L.</au><au>Liboff, A.R.</au><au>McLeod, B.R.</au><au>Smith, S.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nifedipine is an antagonist to cyclotron resonance enhancement of 45Ca incorporation in human lymphocytes</atitle><jtitle>Cell calcium (Edinburgh)</jtitle><addtitle>Cell Calcium</addtitle><date>1987-12</date><risdate>1987</risdate><volume>8</volume><issue>6</issue><spage>413</spage><epage>427</epage><pages>413-427</pages><issn>0143-4160</issn><eissn>1532-1991</eissn><coden>CECADV</coden><abstract>The incorporation of
45Ca in mixed human lymphocytes was measured following one-hour exposures of the cells to combined steady and periodic magnetic fields designed to probe for cyclotron resonance response in calcium incorporation. Measurements were made as a function of magnetic field frequency, up to 30 Hz, and as a function of magnetic field amplitude, up to 1.5 × 10
−4 T
rms. The amplitude measurements demonstrated that the relative
45Ca uptake at resonance follows different mechanisms of interaction above and below 0.2 × 10
−4 T
rms. After adjusting the magnetic field configuration for maximum incorporation, we then determined the effects of the calcium influx blocker nifedipine on
45Ca incorporation, with and without simultaneous exposure to this specific magnetic field combination. The presence of nifedipine in both unexposed and exposed cell suspensions resulted in decreased
45Ca uptake, presumably through the slow inward calcium channels. Evidence was found suggesting that nifedipine acts antagonistially to the
45Ca cyclotron resonance tuning signal.</abstract><cop>Oxford</cop><pub>Elsevier India Pvt Ltd</pub><pmid>3435912</pmid><doi>10.1016/0143-4160(87)90025-X</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0143-4160 |
| ispartof | Cell calcium (Edinburgh), 1987-12, Vol.8 (6), p.413-427 |
| issn | 0143-4160 1532-1991 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77936922 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Calcium - blood Calcium Radioisotopes Cell physiology Fundamental and applied biological sciences. Psychology Humans Lymphocytes - metabolism Membrane and intracellular transports Molecular and cellular biology Nifedipine - pharmacology Particle Accelerators |
| title | Nifedipine is an antagonist to cyclotron resonance enhancement of 45Ca incorporation in human lymphocytes |
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