Ontogenetic development of proenkephalin A and proenkephalin B messenger RNA in fetal pigs
Using solution hybridization analysis and Northern blotting with complementary RNA probes labelled to high specific activity, levels of proenkephalin A and B mRNA were analyzed throughout prenatal development in the hippocampus and striatum of fetal pigs. A differential time course for the appearanc...
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| Veröffentlicht in: | Experimental brain research 1987-01, Vol.69 (1), p.208-212 |
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| container_title | Experimental brain research |
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| creator | PITTIUS, C. W ELLENDORFF, F HOLLT, V PARVIZI, N |
| description | Using solution hybridization analysis and Northern blotting with complementary RNA probes labelled to high specific activity, levels of proenkephalin A and B mRNA were analyzed throughout prenatal development in the hippocampus and striatum of fetal pigs. A differential time course for the appearance of these opioid precursor mRNAs was observed: in hippocampus, both mRNAs increased linearly throughout development with proenkephalin B mRNA increasing faster than proenkephalin A mRNA. In striatum, both mRNAs behaved similarly, increasing to a maximum level around mid-gestation and declining thereafter. The differences might be attributed to differential localization of the two precursor systems in the tissues and might be of functional relevance. |
| doi_str_mv | 10.1007/BF00247043 |
| format | Article |
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The differences might be attributed to differential localization of the two precursor systems in the tissues and might be of functional relevance.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/BF00247043</identifier><identifier>PMID: 3436388</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Brain - embryology ; Brain - metabolism ; Corpus Striatum - embryology ; Corpus Striatum - metabolism ; Embryology: invertebrates and vertebrates. Teratology ; Enkephalins - metabolism ; Enkephalins - physiology ; Fetus - metabolism ; Fundamental and applied biological sciences. 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The differences might be attributed to differential localization of the two precursor systems in the tissues and might be of functional relevance.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - embryology</subject><subject>Brain - metabolism</subject><subject>Corpus Striatum - embryology</subject><subject>Corpus Striatum - metabolism</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Enkephalins - metabolism</subject><subject>Enkephalins - physiology</subject><subject>Fetus - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Gestational Age</subject><subject>Hippocampus - embryology</subject><subject>Hippocampus - metabolism</subject><subject>Molecular embryology</subject><subject>Nucleic Acid Hybridization</subject><subject>Protein Precursors - metabolism</subject><subject>Protein Precursors - physiology</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA, Messenger - physiology</subject><subject>Swine</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxYMo6_px8S7kIB6E6kyTtM1xd_ELREH04qVk08labdPadAX_eyu7rODF0_De-_EYHmNHCOcIkF5MrwBimYIUW2yMUsQRIiTbbAyAMpIZ6l22F8LbjxQpjNhISJGILBuzlwffNwvy1JeWF_RJVdPW5HveON52Dfl3al9NVXo-4cYXf7wprykE8gvq-OP9hA-Wo95UvC0X4YDtOFMFOlzfffZ8dfk0u4nuHq5vZ5O7yAoZ95HWTkgLxigXk9IZ6HSeoUWZKmWsRdROJVDMY2GpQMiUKwwkUmhlCyTrxD47XfUOv30sKfR5XQZLVWU8NcuQp6kWMsvkvyBKjbFWagDPVqDtmhA6cnnblbXpvnKE_Gfx_HfxAT5ety7nNRUbdD3xkJ-scxOsqVxnvC3DBksTEUOC4hvGW4cl</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>PITTIUS, C. 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W ; ELLENDORFF, F ; HOLLT, V ; PARVIZI, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-99f34c0aa5f2e598097b81c14755acc119f560db23ced1085fda064395cd1ecf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - embryology</topic><topic>Brain - metabolism</topic><topic>Corpus Striatum - embryology</topic><topic>Corpus Striatum - metabolism</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Enkephalins - metabolism</topic><topic>Enkephalins - physiology</topic><topic>Fetus - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Gestational Age</topic><topic>Hippocampus - embryology</topic><topic>Hippocampus - metabolism</topic><topic>Molecular embryology</topic><topic>Nucleic Acid Hybridization</topic><topic>Protein Precursors - metabolism</topic><topic>Protein Precursors - physiology</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA, Messenger - physiology</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PITTIUS, C. W</creatorcontrib><creatorcontrib>ELLENDORFF, F</creatorcontrib><creatorcontrib>HOLLT, V</creatorcontrib><creatorcontrib>PARVIZI, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PITTIUS, C. W</au><au>ELLENDORFF, F</au><au>HOLLT, V</au><au>PARVIZI, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ontogenetic development of proenkephalin A and proenkephalin B messenger RNA in fetal pigs</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>69</volume><issue>1</issue><spage>208</spage><epage>212</epage><pages>208-212</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>Using solution hybridization analysis and Northern blotting with complementary RNA probes labelled to high specific activity, levels of proenkephalin A and B mRNA were analyzed throughout prenatal development in the hippocampus and striatum of fetal pigs. A differential time course for the appearance of these opioid precursor mRNAs was observed: in hippocampus, both mRNAs increased linearly throughout development with proenkephalin B mRNA increasing faster than proenkephalin A mRNA. In striatum, both mRNAs behaved similarly, increasing to a maximum level around mid-gestation and declining thereafter. The differences might be attributed to differential localization of the two precursor systems in the tissues and might be of functional relevance.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3436388</pmid><doi>10.1007/BF00247043</doi><tpages>5</tpages></addata></record> |
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| ispartof | Experimental brain research, 1987-01, Vol.69 (1), p.208-212 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Brain - embryology Brain - metabolism Corpus Striatum - embryology Corpus Striatum - metabolism Embryology: invertebrates and vertebrates. Teratology Enkephalins - metabolism Enkephalins - physiology Fetus - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gestational Age Hippocampus - embryology Hippocampus - metabolism Molecular embryology Nucleic Acid Hybridization Protein Precursors - metabolism Protein Precursors - physiology RNA, Messenger - metabolism RNA, Messenger - physiology Swine |
| title | Ontogenetic development of proenkephalin A and proenkephalin B messenger RNA in fetal pigs |
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