Topoisomerases in kinetoplastids
Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as wel...
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| Veröffentlicht in: | Parasitology Today 1996-06, Vol.12 (6), p.226-231 |
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| container_title | Parasitology Today |
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| creator | Burri, C. Bodley, A.L. Shapiro, T.A. |
| description | Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and
Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Armette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets. |
| doi_str_mv | 10.1016/0169-4758(96)10017-X |
| format | Article |
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| ispartof | Parasitology Today, 1996-06, Vol.12 (6), p.226-231 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Fundamental and applied biological sciences. Psychology Leishmania donovani Protozoa trypanosoma |
| title | Topoisomerases in kinetoplastids |
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