Prevention of arterial thrombosis by adenovirus-mediated transfer of cyclooxygenase gene

Prostacyclin is an important vasoprotective molecule. It inhibits platelet aggregation, monocyte interaction with endothelium, and smooth muscle cell lipid accumulation. Vascular cyclooxygenase-1 (COX-1) is the rate-limiting step in prostacyclin synthesis. The objective of this study was to determin...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1996, Vol.93 (1), p.10-17
Hauptverfasser:	ZOLDHELYI, P, MCNATT, J, XIAO-MING XU, LOOSE-MITCHELL, D, MEIDELL, R. S, CLUBB, F. J, BUJA, L. M, WILLERSON, J. T, WU, K. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Angioplasty, Balloon - adverse effects Animals Biological and medical sciences Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Artery Thrombosis - etiology Carotid Artery Thrombosis - metabolism Carotid Artery Thrombosis - prevention & control Diseases of the cardiovascular system Epoprostenol - biosynthesis Epoprostenol - therapeutic use Gene Transfer Techniques Genetic Therapy Genetic Vectors Humans Medical sciences Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Recombinant Proteins - biosynthesis Swine
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