Use of a semi-nested PCR diagnosis test to evaluate antifolate resistance of Plasmodium falciparum isolates

The antifols, inhibitors of the dihydrofolate reductase (DHFR), such as pyrimethamine and proguanil, have been used against Plasmodium falciparum in the areas where chloroquine resistance is widespread. This use has selected resistant strains in Southeast Asia and South America. The resistance is co...

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Veröffentlicht in:	Molecular and cellular probes 1995-12, Vol.9 (6), p.391-397
Hauptverfasser:	Eldin de Pecoulas, P, Abdallah, B, Dje, M K, Basco, L K, le Bras, J, Mazabraud, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - pharmacology Base Sequence Codon - genetics DNA Mutational Analysis DNA, Protozoan - genetics Drug Resistance - genetics Folic Acid Antagonists - pharmacology Molecular Sequence Data Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Point Mutation Polymerase Chain Reaction - methods Proguanil - pharmacology Protozoan Proteins - antagonists & inhibitors Protozoan Proteins - genetics Pyrimethamine - pharmacology Sensitivity and Specificity Tetrahydrofolate Dehydrogenase - genetics
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