Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat
The free radical theory of aging was examined by measuring the formation of superoxide radical (SOR) and the level of lipid peroxides in various tissues of the aging rat. A significant increase in SOR production was seen in mitochondria prepared from the brain and the heart as rats aged. An elevatio...
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| Veröffentlicht in: | Mechanisms of ageing and development 1987-11, Vol.41 (1), p.125-137 |
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| container_title | Mechanisms of ageing and development |
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| creator | Sawada, Masaaki Carlson, John C. |
| description | The free radical theory of aging was examined by measuring the formation of superoxide radical (SOR) and the level of lipid peroxides in various tissues of the aging rat. A significant increase in SOR production was seen in mitochondria prepared from the brain and the heart as rats aged. An elevation in the level of lipid peroxidation was also found in whole tissue homogenates of the brain and the liver. Vitamin E concentrations in the blood rose rapidly in young rats and remained steady except for a non significant drop in old animals. These results suggest that age-related degeneration of various tissues in the rat may be due to a rise in free radical production in the mitochondria. |
| doi_str_mv | 10.1016/0047-6374(87)90057-1 |
| format | Article |
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A significant increase in SOR production was seen in mitochondria prepared from the brain and the heart as rats aged. An elevation in the level of lipid peroxidation was also found in whole tissue homogenates of the brain and the liver. Vitamin E concentrations in the blood rose rapidly in young rats and remained steady except for a non significant drop in old animals. These results suggest that age-related degeneration of various tissues in the rat may be due to a rise in free radical production in the mitochondria.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/0047-6374(87)90057-1</identifier><identifier>PMID: 2828774</identifier><identifier>CODEN: MAGDA3</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Ageing, cell death ; Aging - metabolism ; Animals ; Biological and medical sciences ; Brain - metabolism ; Brain, heart and liver mitochondria ; Cell physiology ; Electron Spin Resonance Spectroscopy ; Free Radicals ; Fundamental and applied biological sciences. Psychology ; Lipid peroxidation ; Lipid Peroxides - metabolism ; Liver - metabolism ; Male ; Mitochondria - metabolism ; Molecular and cellular biology ; Myocardium - metabolism ; Rats ; Rats, Inbred Strains ; Superoxide radical ; Superoxides - metabolism ; Vitamin E</subject><ispartof>Mechanisms of ageing and development, 1987-11, Vol.41 (1), p.125-137</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-cfa9a641add4cdc46b80daf3d297e05283e524d5b6e748b61c528198bd9348673</citedby><cites>FETCH-LOGICAL-c386t-cfa9a641add4cdc46b80daf3d297e05283e524d5b6e748b61c528198bd9348673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0047637487900571$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7654824$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2828774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawada, Masaaki</creatorcontrib><creatorcontrib>Carlson, John C.</creatorcontrib><title>Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>The free radical theory of aging was examined by measuring the formation of superoxide radical (SOR) and the level of lipid peroxides in various tissues of the aging rat. A significant increase in SOR production was seen in mitochondria prepared from the brain and the heart as rats aged. An elevation in the level of lipid peroxidation was also found in whole tissue homogenates of the brain and the liver. Vitamin E concentrations in the blood rose rapidly in young rats and remained steady except for a non significant drop in old animals. These results suggest that age-related degeneration of various tissues in the rat may be due to a rise in free radical production in the mitochondria.</description><subject>Ageing, cell death</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain, heart and liver mitochondria</subject><subject>Cell physiology</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Free Radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxides - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mitochondria - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Myocardium - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Superoxide radical</subject><subject>Superoxides - metabolism</subject><subject>Vitamin E</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EKkvhDUDyAaEiNWA7ju1cKqEVtJUqcYGzNbEnXaPEWeykpW_fZDfaI6eR5__-kfUR8p6zL5xx9ZUxqQtVanlh9OeasUoX_AXZcKNFoQRXL8nmhLwmb3L-wxjjUqgzciaMMFrLDXnc7iDeY6Yh0jztMQ3_gkeawAcHHYXoaRf2wdNT1A6phzEMcamMO6RNghAv6Q4hjWvhARP1Uwrx_kB0ocUx9EiH9vBOML4lr1roMr5b5zn5_eP7r-1Ncffz-nb77a5wpVFj4VqoQUkO3kvnnVSNYR7a0otaI6uEKbES0leNQi1No7ibd7w2ja9LaZQuz8mn4919Gv5OmEfbh-yw6yDiMGWrdS1UVVYzKI-gS0POCVu7T6GH9GQ5s4tvu8i0i0xrtD34tnyufVjvT02P_lRaBc_5xzWHPAttE0QX8gnTqpJGLNjVEcPZxUPAZLMLGB36kNCN1g_h__94BletnKQ</recordid><startdate>19871101</startdate><enddate>19871101</enddate><creator>Sawada, Masaaki</creator><creator>Carlson, John C.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19871101</creationdate><title>Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat</title><author>Sawada, Masaaki ; Carlson, John C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-cfa9a641add4cdc46b80daf3d297e05283e524d5b6e748b61c528198bd9348673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Ageing, cell death</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain, heart and liver mitochondria</topic><topic>Cell physiology</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>Free Radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxides - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mitochondria - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Myocardium - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Superoxide radical</topic><topic>Superoxides - metabolism</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawada, Masaaki</creatorcontrib><creatorcontrib>Carlson, John C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sawada, Masaaki</au><au>Carlson, John C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>1987-11-01</date><risdate>1987</risdate><volume>41</volume><issue>1</issue><spage>125</spage><epage>137</epage><pages>125-137</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><coden>MAGDA3</coden><abstract>The free radical theory of aging was examined by measuring the formation of superoxide radical (SOR) and the level of lipid peroxides in various tissues of the aging rat. A significant increase in SOR production was seen in mitochondria prepared from the brain and the heart as rats aged. An elevation in the level of lipid peroxidation was also found in whole tissue homogenates of the brain and the liver. Vitamin E concentrations in the blood rose rapidly in young rats and remained steady except for a non significant drop in old animals. These results suggest that age-related degeneration of various tissues in the rat may be due to a rise in free radical production in the mitochondria.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>2828774</pmid><doi>10.1016/0047-6374(87)90057-1</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0047-6374 |
| ispartof | Mechanisms of ageing and development, 1987-11, Vol.41 (1), p.125-137 |
| issn | 0047-6374 1872-6216 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Ageing, cell death Aging - metabolism Animals Biological and medical sciences Brain - metabolism Brain, heart and liver mitochondria Cell physiology Electron Spin Resonance Spectroscopy Free Radicals Fundamental and applied biological sciences. Psychology Lipid peroxidation Lipid Peroxides - metabolism Liver - metabolism Male Mitochondria - metabolism Molecular and cellular biology Myocardium - metabolism Rats Rats, Inbred Strains Superoxide radical Superoxides - metabolism Vitamin E |
| title | Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat |
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