Randomised trial of excimer laser angioplasty versus balloon angioplasty for treatment of obstructive coronary artery disease
Summary Background Excimer laser coronary angioplasty is reported to give excellent procedural results for treatment of complex coronary lesions, but this method has not been compared with balloon angioplasty in a randomised trial. Methods Patients (n=308) with stable angina and coronary lesions lon...
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 1996-01, Vol.347 (8994), p.79-84 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 84 |
|---|---|
| container_issue | 8994 |
| container_start_page | 79 |
| container_title | The Lancet (British edition) |
| container_volume | 347 |
| creator | Appelman, Y.E.A Piek, J.J David, G.K Tijssen, J.G.P Koelemay, M.J Strikwerda, S de Feyter, P.J Serruys, P.W Montauban van Swijndregt, E.W.J Margolis, J.R Koolen, J.J |
| description | Summary
Background Excimer laser coronary angioplasty is reported to give excellent procedural results for treatment of complex coronary lesions, but this method has not been compared with balloon angioplasty in a randomised trial.
Methods Patients (n=308) with stable angina and coronary lesions longer than 10 mm on visual assessment were included. 151 patients (158 lesions) were assigned randomly to laser angioplasty and 157 (167 lesions) to balloon angioplasty. The primary clinical endpoints were death, myocardial infarction, coronary bypass surgery, or repeat coronary angioplasty of the randomised segment during 6 months of follow-up. The primary angiographic end-point was the minimal lumen diameter at follow-up in relation to the baseline value (net gain), as determined by quantitative coronary angiography.
Findings Laser angioplasty was followed by balloon angioplasty in 98% of procedures. The angiographic success rate was 80% in patients treated with laser angioplasty compared with 79% in patients treated with balloon angioplasty. There were no deaths. Myocardial infarction, coronary bypass surgery, and repeat angioplasty occurred in 4·6%, 10·6%, and 21·2%, respectively, of the patients in the laser angioplasty group compared with 5·7%, 10·8%, and 18·5% of the balloon angioplasty group. Net mean (SD) gain in minimal lumen diameter was 0·40 (0·69) mm in patients treated with laser angioplasty and 0·48 (0·66) mm in those treated with balloon angioplasty (p=0·34). The restenosis rate (>50% diameter stenosis) was 51·6% in the laser angioplasty group versus 41·3% in the balloon angioplasty group (p=0·13).
Interpretation Excimer laser angioplasty followed by balloon angioplasty provides no benefit additional to balloon angioplasty alone with respect to the initial and long-term clinical and angiographic outcome in the treatment of obstructive coronary artery disease. |
| doi_str_mv | 10.1016/S0140-6736(96)90209-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77923909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0140673696902093</els_id><sourcerecordid>9096948</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-30053d4d1c56b89a8020ef9f3931126b63f17f5a5b6ef1790fe89a2d9728f3d33</originalsourceid><addsrcrecordid>eNqFUU2LFDEUDKKs4-hPWGhEFj20Jp2P7pxEFnWFBcEP8BbSyYtk6U7GJD3sHvzvpp1hYL0IIe_Bq1SqXiF0TvBrgol48xUThlvRU_FSilcSd1i29AHaENazlrP-x0O0OUEeoyc532CMmcD8DJ0NnA6U8Q36_UUHG2efwTYleT010TVwa_wMqZl0rrcOP33c1b7cNXtIecnNqKcpxnBv5GKqDKDLDKGsLHHMJS2m-D00JqYYdLprdCpQi60fVvKn6JHTU4Znx7pF3z-8_3Z51V5__vjp8t11a5jgpaUYc2qZJYaLcZB6qGbBSUclJaQTo6CO9I5rPgqoncQOKqqzsu8GRy2lW3Rx4N2l-GuBXFR1bGCadIC4ZNX3sqMSywp8_g_wJi4pVG2KSIkZ7ermtogfQCbFnBM4tUt-ru4UwWrNRv3NRq2LV7KeNRu1qjg_ki_jDPb06hhGnb84znU2enJJB-PzCdZJKdiwanx7gEHd2N5DUtl4CAasT2CKstH_R8gfL4-tVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199043285</pqid></control><display><type>article</type><title>Randomised trial of excimer laser angioplasty versus balloon angioplasty for treatment of obstructive coronary artery disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Business Source Complete</source><creator>Appelman, Y.E.A ; Piek, J.J ; David, G.K ; Tijssen, J.G.P ; Koelemay, M.J ; Strikwerda, S ; de Feyter, P.J ; Serruys, P.W ; Montauban van Swijndregt, E.W.J ; Margolis, J.R ; Koolen, J.J</creator><creatorcontrib>Appelman, Y.E.A ; Piek, J.J ; David, G.K ; Tijssen, J.G.P ; Koelemay, M.J ; Strikwerda, S ; de Feyter, P.J ; Serruys, P.W ; Montauban van Swijndregt, E.W.J ; Margolis, J.R ; Koolen, J.J</creatorcontrib><description>Summary
Background Excimer laser coronary angioplasty is reported to give excellent procedural results for treatment of complex coronary lesions, but this method has not been compared with balloon angioplasty in a randomised trial.
Methods Patients (n=308) with stable angina and coronary lesions longer than 10 mm on visual assessment were included. 151 patients (158 lesions) were assigned randomly to laser angioplasty and 157 (167 lesions) to balloon angioplasty. The primary clinical endpoints were death, myocardial infarction, coronary bypass surgery, or repeat coronary angioplasty of the randomised segment during 6 months of follow-up. The primary angiographic end-point was the minimal lumen diameter at follow-up in relation to the baseline value (net gain), as determined by quantitative coronary angiography.
Findings Laser angioplasty was followed by balloon angioplasty in 98% of procedures. The angiographic success rate was 80% in patients treated with laser angioplasty compared with 79% in patients treated with balloon angioplasty. There were no deaths. Myocardial infarction, coronary bypass surgery, and repeat angioplasty occurred in 4·6%, 10·6%, and 21·2%, respectively, of the patients in the laser angioplasty group compared with 5·7%, 10·8%, and 18·5% of the balloon angioplasty group. Net mean (SD) gain in minimal lumen diameter was 0·40 (0·69) mm in patients treated with laser angioplasty and 0·48 (0·66) mm in those treated with balloon angioplasty (p=0·34). The restenosis rate (>50% diameter stenosis) was 51·6% in the laser angioplasty group versus 41·3% in the balloon angioplasty group (p=0·13).
Interpretation Excimer laser angioplasty followed by balloon angioplasty provides no benefit additional to balloon angioplasty alone with respect to the initial and long-term clinical and angiographic outcome in the treatment of obstructive coronary artery disease.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(96)90209-3</identifier><identifier>PMID: 8538345</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Angioplasty ; Angioplasty, Balloon, Coronary ; Angioplasty, Balloon, Laser-Assisted ; Biological and medical sciences ; Cardiovascular disease ; Clinical trials ; Coronary Angiography ; Coronary Disease - surgery ; Coronary Disease - therapy ; Coronary vessels ; Diseases of the cardiovascular system ; Female ; Follow-Up Studies ; Humans ; Lasers ; Lesions ; Male ; Medical research ; Medical sciences ; Middle Aged ; Myocardial infarction ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Recurrence ; Treatment Outcome</subject><ispartof>The Lancet (British edition), 1996-01, Vol.347 (8994), p.79-84</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Jan 13, 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-30053d4d1c56b89a8020ef9f3931126b63f17f5a5b6ef1790fe89a2d9728f3d33</citedby><cites>FETCH-LOGICAL-c465t-30053d4d1c56b89a8020ef9f3931126b63f17f5a5b6ef1790fe89a2d9728f3d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673696902093$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2996489$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8538345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Appelman, Y.E.A</creatorcontrib><creatorcontrib>Piek, J.J</creatorcontrib><creatorcontrib>David, G.K</creatorcontrib><creatorcontrib>Tijssen, J.G.P</creatorcontrib><creatorcontrib>Koelemay, M.J</creatorcontrib><creatorcontrib>Strikwerda, S</creatorcontrib><creatorcontrib>de Feyter, P.J</creatorcontrib><creatorcontrib>Serruys, P.W</creatorcontrib><creatorcontrib>Montauban van Swijndregt, E.W.J</creatorcontrib><creatorcontrib>Margolis, J.R</creatorcontrib><creatorcontrib>Koolen, J.J</creatorcontrib><title>Randomised trial of excimer laser angioplasty versus balloon angioplasty for treatment of obstructive coronary artery disease</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Summary
Background Excimer laser coronary angioplasty is reported to give excellent procedural results for treatment of complex coronary lesions, but this method has not been compared with balloon angioplasty in a randomised trial.
Methods Patients (n=308) with stable angina and coronary lesions longer than 10 mm on visual assessment were included. 151 patients (158 lesions) were assigned randomly to laser angioplasty and 157 (167 lesions) to balloon angioplasty. The primary clinical endpoints were death, myocardial infarction, coronary bypass surgery, or repeat coronary angioplasty of the randomised segment during 6 months of follow-up. The primary angiographic end-point was the minimal lumen diameter at follow-up in relation to the baseline value (net gain), as determined by quantitative coronary angiography.
Findings Laser angioplasty was followed by balloon angioplasty in 98% of procedures. The angiographic success rate was 80% in patients treated with laser angioplasty compared with 79% in patients treated with balloon angioplasty. There were no deaths. Myocardial infarction, coronary bypass surgery, and repeat angioplasty occurred in 4·6%, 10·6%, and 21·2%, respectively, of the patients in the laser angioplasty group compared with 5·7%, 10·8%, and 18·5% of the balloon angioplasty group. Net mean (SD) gain in minimal lumen diameter was 0·40 (0·69) mm in patients treated with laser angioplasty and 0·48 (0·66) mm in those treated with balloon angioplasty (p=0·34). The restenosis rate (>50% diameter stenosis) was 51·6% in the laser angioplasty group versus 41·3% in the balloon angioplasty group (p=0·13).
Interpretation Excimer laser angioplasty followed by balloon angioplasty provides no benefit additional to balloon angioplasty alone with respect to the initial and long-term clinical and angiographic outcome in the treatment of obstructive coronary artery disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioplasty</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Angioplasty, Balloon, Laser-Assisted</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Clinical trials</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - surgery</subject><subject>Coronary Disease - therapy</subject><subject>Coronary vessels</subject><subject>Diseases of the cardiovascular system</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lasers</subject><subject>Lesions</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Recurrence</subject><subject>Treatment Outcome</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUU2LFDEUDKKs4-hPWGhEFj20Jp2P7pxEFnWFBcEP8BbSyYtk6U7GJD3sHvzvpp1hYL0IIe_Bq1SqXiF0TvBrgol48xUThlvRU_FSilcSd1i29AHaENazlrP-x0O0OUEeoyc532CMmcD8DJ0NnA6U8Q36_UUHG2efwTYleT010TVwa_wMqZl0rrcOP33c1b7cNXtIecnNqKcpxnBv5GKqDKDLDKGsLHHMJS2m-D00JqYYdLprdCpQi60fVvKn6JHTU4Znx7pF3z-8_3Z51V5__vjp8t11a5jgpaUYc2qZJYaLcZB6qGbBSUclJaQTo6CO9I5rPgqoncQOKqqzsu8GRy2lW3Rx4N2l-GuBXFR1bGCadIC4ZNX3sqMSywp8_g_wJi4pVG2KSIkZ7ermtogfQCbFnBM4tUt-ru4UwWrNRv3NRq2LV7KeNRu1qjg_ki_jDPb06hhGnb84znU2enJJB-PzCdZJKdiwanx7gEHd2N5DUtl4CAasT2CKstH_R8gfL4-tVQ</recordid><startdate>19960113</startdate><enddate>19960113</enddate><creator>Appelman, Y.E.A</creator><creator>Piek, J.J</creator><creator>David, G.K</creator><creator>Tijssen, J.G.P</creator><creator>Koelemay, M.J</creator><creator>Strikwerda, S</creator><creator>de Feyter, P.J</creator><creator>Serruys, P.W</creator><creator>Montauban van Swijndregt, E.W.J</creator><creator>Margolis, J.R</creator><creator>Koolen, J.J</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19960113</creationdate><title>Randomised trial of excimer laser angioplasty versus balloon angioplasty for treatment of obstructive coronary artery disease</title><author>Appelman, Y.E.A ; Piek, J.J ; David, G.K ; Tijssen, J.G.P ; Koelemay, M.J ; Strikwerda, S ; de Feyter, P.J ; Serruys, P.W ; Montauban van Swijndregt, E.W.J ; Margolis, J.R ; Koolen, J.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-30053d4d1c56b89a8020ef9f3931126b63f17f5a5b6ef1790fe89a2d9728f3d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angioplasty</topic><topic>Angioplasty, Balloon, Coronary</topic><topic>Angioplasty, Balloon, Laser-Assisted</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular disease</topic><topic>Clinical trials</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - surgery</topic><topic>Coronary Disease - therapy</topic><topic>Coronary vessels</topic><topic>Diseases of the cardiovascular system</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lasers</topic><topic>Lesions</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Recurrence</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Appelman, Y.E.A</creatorcontrib><creatorcontrib>Piek, J.J</creatorcontrib><creatorcontrib>David, G.K</creatorcontrib><creatorcontrib>Tijssen, J.G.P</creatorcontrib><creatorcontrib>Koelemay, M.J</creatorcontrib><creatorcontrib>Strikwerda, S</creatorcontrib><creatorcontrib>de Feyter, P.J</creatorcontrib><creatorcontrib>Serruys, P.W</creatorcontrib><creatorcontrib>Montauban van Swijndregt, E.W.J</creatorcontrib><creatorcontrib>Margolis, J.R</creatorcontrib><creatorcontrib>Koolen, J.J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Appelman, Y.E.A</au><au>Piek, J.J</au><au>David, G.K</au><au>Tijssen, J.G.P</au><au>Koelemay, M.J</au><au>Strikwerda, S</au><au>de Feyter, P.J</au><au>Serruys, P.W</au><au>Montauban van Swijndregt, E.W.J</au><au>Margolis, J.R</au><au>Koolen, J.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomised trial of excimer laser angioplasty versus balloon angioplasty for treatment of obstructive coronary artery disease</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1996-01-13</date><risdate>1996</risdate><volume>347</volume><issue>8994</issue><spage>79</spage><epage>84</epage><pages>79-84</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Summary
Background Excimer laser coronary angioplasty is reported to give excellent procedural results for treatment of complex coronary lesions, but this method has not been compared with balloon angioplasty in a randomised trial.
Methods Patients (n=308) with stable angina and coronary lesions longer than 10 mm on visual assessment were included. 151 patients (158 lesions) were assigned randomly to laser angioplasty and 157 (167 lesions) to balloon angioplasty. The primary clinical endpoints were death, myocardial infarction, coronary bypass surgery, or repeat coronary angioplasty of the randomised segment during 6 months of follow-up. The primary angiographic end-point was the minimal lumen diameter at follow-up in relation to the baseline value (net gain), as determined by quantitative coronary angiography.
Findings Laser angioplasty was followed by balloon angioplasty in 98% of procedures. The angiographic success rate was 80% in patients treated with laser angioplasty compared with 79% in patients treated with balloon angioplasty. There were no deaths. Myocardial infarction, coronary bypass surgery, and repeat angioplasty occurred in 4·6%, 10·6%, and 21·2%, respectively, of the patients in the laser angioplasty group compared with 5·7%, 10·8%, and 18·5% of the balloon angioplasty group. Net mean (SD) gain in minimal lumen diameter was 0·40 (0·69) mm in patients treated with laser angioplasty and 0·48 (0·66) mm in those treated with balloon angioplasty (p=0·34). The restenosis rate (>50% diameter stenosis) was 51·6% in the laser angioplasty group versus 41·3% in the balloon angioplasty group (p=0·13).
Interpretation Excimer laser angioplasty followed by balloon angioplasty provides no benefit additional to balloon angioplasty alone with respect to the initial and long-term clinical and angiographic outcome in the treatment of obstructive coronary artery disease.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>8538345</pmid><doi>10.1016/S0140-6736(96)90209-3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1996-01, Vol.347 (8994), p.79-84 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77923909 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Business Source Complete |
| subjects | Adult Aged Aged, 80 and over Angioplasty Angioplasty, Balloon, Coronary Angioplasty, Balloon, Laser-Assisted Biological and medical sciences Cardiovascular disease Clinical trials Coronary Angiography Coronary Disease - surgery Coronary Disease - therapy Coronary vessels Diseases of the cardiovascular system Female Follow-Up Studies Humans Lasers Lesions Male Medical research Medical sciences Middle Aged Myocardial infarction Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Recurrence Treatment Outcome |
| title | Randomised trial of excimer laser angioplasty versus balloon angioplasty for treatment of obstructive coronary artery disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T19%3A52%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Randomised%20trial%20of%20excimer%20laser%20angioplasty%20versus%20balloon%20angioplasty%20for%20treatment%20of%20obstructive%20coronary%20artery%20disease&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Appelman,%20Y.E.A&rft.date=1996-01-13&rft.volume=347&rft.issue=8994&rft.spage=79&rft.epage=84&rft.pages=79-84&rft.issn=0140-6736&rft.eissn=1474-547X&rft.coden=LANCAO&rft_id=info:doi/10.1016/S0140-6736(96)90209-3&rft_dat=%3Cproquest_cross%3E9096948%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199043285&rft_id=info:pmid/8538345&rft_els_id=S0140673696902093&rfr_iscdi=true |