Associations between dietary factors and serum lipids by apolipoprotein E polymorphism
A geographically based observational study of 852 nondiabetic Hispanic and non-Hispanic white persons in southern Colorado aged 20-74 y was conducted to determine whether diet-lipid associations were modified by the apolipoprotein E (apoE, protein; APOE, gene) polymorphism. Subjects were seen for up...
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| Veröffentlicht in: | The American journal of clinical nutrition 1996-01, Vol.63 (1), p.87-95 |
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| creator | Marshall, JA Kamboh, MI Bessesen, DH Hoag, S Hamman, RF Ferrell, RE |
| description | A geographically based observational study of 852 nondiabetic Hispanic and non-Hispanic white persons in southern Colorado aged 20-74 y was conducted to determine whether diet-lipid associations were modified by the apolipoprotein E (apoE, protein; APOE, gene) polymorphism. Subjects were seen for up to three visits from 1984 to 1992. A 24-h diet recall was collected and fasting serum lipid concentrations were measured at all visits. In longitudinal-regression analyses, dietary factors were significantly associated with serum lipid concentrations in the directions expected based on the large amount of literature on this topic. The positive relation between dietary cholesterol and serum total and low-density-lipoprotein cholesterol was strongest in Hispanic subjects with the APOE*2 allele (E2/ 2,3/2 genotypes) and non-Hispanic white subjects with the APOE*3 allele (E3/3 genotype), and there was no association in subjects with the APOE*4 allele (E4/3, 4/4 genotypes) in either ethnic group. No other statistically significant differences in the relations between dietary factors and serum lipid concentrations by APOE polymorphism were identified. These findings suggest that the APOE polymorphism plays only a minor role in modifying the association between dietary factors and serum lipids. |
| doi_str_mv | 10.1093/ajcn/63.1.87 |
| format | Article |
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Subjects were seen for up to three visits from 1984 to 1992. A 24-h diet recall was collected and fasting serum lipid concentrations were measured at all visits. In longitudinal-regression analyses, dietary factors were significantly associated with serum lipid concentrations in the directions expected based on the large amount of literature on this topic. The positive relation between dietary cholesterol and serum total and low-density-lipoprotein cholesterol was strongest in Hispanic subjects with the APOE*2 allele (E2/ 2,3/2 genotypes) and non-Hispanic white subjects with the APOE*3 allele (E3/3 genotype), and there was no association in subjects with the APOE*4 allele (E4/3, 4/4 genotypes) in either ethnic group. No other statistically significant differences in the relations between dietary factors and serum lipid concentrations by APOE polymorphism were identified. These findings suggest that the APOE polymorphism plays only a minor role in modifying the association between dietary factors and serum lipids.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/63.1.87</identifier><identifier>PMID: 8604675</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adult ; Aged ; Alleles ; Anthropology. Demography ; Apolipoproteins E - genetics ; Base Sequence ; Biological and medical sciences ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Clinical trials ; Colorado ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - genetics ; Diet ; Dietary Fats - administration & dosage ; DNA Primers - chemistry ; European Continental Ancestry Group - genetics ; Female ; Genotype ; Hispanic Americans - genetics ; Human physiology applied to population studies and life conditions. Human ecophysiology ; Humans ; Lipids ; Lipids - blood ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Proteins</subject><ispartof>The American journal of clinical nutrition, 1996-01, Vol.63 (1), p.87-95</ispartof><rights>1996 American Society for Nutrition.</rights><rights>1996 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. 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Subjects were seen for up to three visits from 1984 to 1992. A 24-h diet recall was collected and fasting serum lipid concentrations were measured at all visits. In longitudinal-regression analyses, dietary factors were significantly associated with serum lipid concentrations in the directions expected based on the large amount of literature on this topic. The positive relation between dietary cholesterol and serum total and low-density-lipoprotein cholesterol was strongest in Hispanic subjects with the APOE*2 allele (E2/ 2,3/2 genotypes) and non-Hispanic white subjects with the APOE*3 allele (E3/3 genotype), and there was no association in subjects with the APOE*4 allele (E4/3, 4/4 genotypes) in either ethnic group. No other statistically significant differences in the relations between dietary factors and serum lipid concentrations by APOE polymorphism were identified. These findings suggest that the APOE polymorphism plays only a minor role in modifying the association between dietary factors and serum lipids.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Anthropology. Demography</subject><subject>Apolipoproteins E - genetics</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Clinical trials</subject><subject>Colorado</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diet</subject><subject>Dietary Fats - administration & dosage</subject><subject>DNA Primers - chemistry</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Hispanic Americans - genetics</subject><subject>Human physiology applied to population studies and life conditions. Human ecophysiology</subject><subject>Humans</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Proteins</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E2LFDEQBuAgyjqu3rwKjYgnezaVdOfjuCzrByx4Ua8hnVRjhu6kTbqV-fdmmGEP4ikU9fCmeAl5DXQPVPMbe3DxRvA97JV8QnaguWo5o_Ip2VFKWatB9M_Ji1IOlALrlLgiV0rQTsh-R37clpJcsGtIsTQDrn8QY-MDrjYfm9G6NeXS2OibgnmbmykswVd4bOyS6pCWnFYMsblv6nycU15-hjK_JM9GOxV8dXmvyfeP99_uPrcPXz99ubt9aF3H5NqC5Ayh7xQqp4DJAQawXrAOOPSD8JQBH5nnAnnnmKBSa9lTMSLY3gtJ-TV5f86tZ_zasKxmDsXhNNmIaStGSs04cFbh23_gIW051ttMBRqUZn1FH87I5VRKxtEsOcy1CAPUnLo2p66N4AaMkpW_uWRuw4z-EV_Krft3l70tzk5jttGF8siY7hXXpxhxZliL-h0wm-ICRoc-ZHSr8Sn8__-_rkuZPg</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>Marshall, JA</creator><creator>Kamboh, MI</creator><creator>Bessesen, DH</creator><creator>Hoag, S</creator><creator>Hamman, RF</creator><creator>Ferrell, RE</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199601</creationdate><title>Associations between dietary factors and serum lipids by apolipoprotein E polymorphism</title><author>Marshall, JA ; Kamboh, MI ; Bessesen, DH ; Hoag, S ; Hamman, RF ; Ferrell, RE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-1732e1548e8c8127b1b1ad6241315b6d0213f2d36e34c2607997506fe1a5d6703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Anthropology. Demography</topic><topic>Apolipoproteins E - genetics</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Clinical trials</topic><topic>Colorado</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diet</topic><topic>Dietary Fats - administration & dosage</topic><topic>DNA Primers - chemistry</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Hispanic Americans - genetics</topic><topic>Human physiology applied to population studies and life conditions. Human ecophysiology</topic><topic>Humans</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marshall, JA</creatorcontrib><creatorcontrib>Kamboh, MI</creatorcontrib><creatorcontrib>Bessesen, DH</creatorcontrib><creatorcontrib>Hoag, S</creatorcontrib><creatorcontrib>Hamman, RF</creatorcontrib><creatorcontrib>Ferrell, RE</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marshall, JA</au><au>Kamboh, MI</au><au>Bessesen, DH</au><au>Hoag, S</au><au>Hamman, RF</au><au>Ferrell, RE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between dietary factors and serum lipids by apolipoprotein E polymorphism</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1996-01</date><risdate>1996</risdate><volume>63</volume><issue>1</issue><spage>87</spage><epage>95</epage><pages>87-95</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>A geographically based observational study of 852 nondiabetic Hispanic and non-Hispanic white persons in southern Colorado aged 20-74 y was conducted to determine whether diet-lipid associations were modified by the apolipoprotein E (apoE, protein; APOE, gene) polymorphism. Subjects were seen for up to three visits from 1984 to 1992. A 24-h diet recall was collected and fasting serum lipid concentrations were measured at all visits. In longitudinal-regression analyses, dietary factors were significantly associated with serum lipid concentrations in the directions expected based on the large amount of literature on this topic. The positive relation between dietary cholesterol and serum total and low-density-lipoprotein cholesterol was strongest in Hispanic subjects with the APOE*2 allele (E2/ 2,3/2 genotypes) and non-Hispanic white subjects with the APOE*3 allele (E3/3 genotype), and there was no association in subjects with the APOE*4 allele (E4/3, 4/4 genotypes) in either ethnic group. No other statistically significant differences in the relations between dietary factors and serum lipid concentrations by APOE polymorphism were identified. These findings suggest that the APOE polymorphism plays only a minor role in modifying the association between dietary factors and serum lipids.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>8604675</pmid><doi>10.1093/ajcn/63.1.87</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Alleles Anthropology. Demography Apolipoproteins E - genetics Base Sequence Biological and medical sciences Cholesterol, HDL - blood Cholesterol, LDL - blood Clinical trials Colorado Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Diet Dietary Fats - administration & dosage DNA Primers - chemistry European Continental Ancestry Group - genetics Female Genotype Hispanic Americans - genetics Human physiology applied to population studies and life conditions. Human ecophysiology Humans Lipids Lipids - blood Male Medical sciences Middle Aged Molecular Sequence Data Polymerase Chain Reaction Polymorphism, Genetic Proteins |
| title | Associations between dietary factors and serum lipids by apolipoprotein E polymorphism |
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