The effect of insulin and insulin-like growth factors on the expression of steroidogenic enzymes in a human ovarian thecal-like tumor cell model

To determine the effects of insulin and insulin-like growth factors (IGF-I and IGF-II) on steroidogenesis and steroidogenic enzyme expression in a human ovarian thecal-like tumor cell culture model system. Human ovarian thecal-like tumor cells treated with forskolin and insulin IGF-I or IGF-II were...

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Veröffentlicht in:	Fertility and sterility 1996-01, Vol.65 (1), p.87-93
Hauptverfasser:	McGee, Elizabeth A., Sawetawan, Chiravudh, Bird, Ian, Rainey, William E., Carr, Bruce R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxysteroid Dehydrogenases - genetics 3-Hydroxysteroid Dehydrogenases - metabolism 3βHSD Androstenedione - metabolism Base Sequence Cholesterol Side-Chain Cleavage Enzyme - genetics Cholesterol Side-Chain Cleavage Enzyme - metabolism Female Gene Expression Regulation, Enzymologic - drug effects Humans insulin Insulin - pharmacology insulin-like growth factors Molecular Sequence Data Ovarian Neoplasms - enzymology Ovary P450c17 Progesterone - metabolism RNA, Messenger - analysis Somatomedins - pharmacology Steroid 21-Hydroxylase - genetics Steroid 21-Hydroxylase - metabolism steroidogenesis Steroids - biosynthesis theca Theca Cells - enzymology Tumor Cells, Cultured
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