Multiple proteins bind the insulin response element in the human IGFBP-1 promoter
An insulin response element (IRE) has been identified ∼100 base pairs (bp) 5′ to the transcription start site of the human insulin-like growth factor binding protein-1 (hIGFBP-1) gene. This cis element appears crucial to the multihormonal regulation of hIGFBP-1 expression in liver, since (i) an inta...
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| Veröffentlicht in: | Progress in growth factor research 1995, Vol.6 (2), p.93-101 |
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| container_title | Progress in growth factor research |
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| creator | Powell, David R. Allander, Susanne V. Scheimann, Ann O. Wasserman, Richard M. Durham, Susan K. Suwanichkul, Adisak |
| description | An insulin response element (IRE) has been identified ∼100 base pairs (bp) 5′ to the transcription start site of the human insulin-like growth factor binding protein-1 (hIGFBP-1) gene. This
cis element appears crucial to the multihormonal regulation of hIGFBP-1 expression in liver, since (i) an intact IRE is required for maximal stimulation of hIGFBP-1 promoter activity by dexamethasone, and (ii) the IRE confers activity. Further progress in understanding how the IRE confers insulin and glucocorticoid effects requires identification of transcription factors confering effects of these hormones. D-site binding protein (DBP), and members of the hepatic nuclear factor 3 (HNF 3) and high mobility group I/Y (HMG I/Y) protein families, each known to bind DNA elements similar in sequence to the IRE, were tested for IRE binding. DBP, HMGI and HNF 3β each protected the hIGFBP-1 IRE from DN AseI digestion. Additional studies are required to establish whether binding of any of these proteins to the IRE is important to the regulation of hIGFBP-1 expression by insulin and/or glucocorticoids. |
| doi_str_mv | 10.1016/0955-2235(95)00034-8 |
| format | Article |
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cis element appears crucial to the multihormonal regulation of hIGFBP-1 expression in liver, since (i) an intact IRE is required for maximal stimulation of hIGFBP-1 promoter activity by dexamethasone, and (ii) the IRE confers activity. Further progress in understanding how the IRE confers insulin and glucocorticoid effects requires identification of transcription factors confering effects of these hormones. D-site binding protein (DBP), and members of the hepatic nuclear factor 3 (HNF 3) and high mobility group I/Y (HMG I/Y) protein families, each known to bind DNA elements similar in sequence to the IRE, were tested for IRE binding. DBP, HMGI and HNF 3β each protected the hIGFBP-1 IRE from DN AseI digestion. Additional studies are required to establish whether binding of any of these proteins to the IRE is important to the regulation of hIGFBP-1 expression by insulin and/or glucocorticoids.</description><identifier>ISSN: 0955-2235</identifier><identifier>DOI: 10.1016/0955-2235(95)00034-8</identifier><identifier>PMID: 8817651</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>DBP ; Deoxyribonuclease I - metabolism ; DNA - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Hepatocyte Nuclear Factor 3-beta ; High Mobility Group Proteins - metabolism ; HMGA1a Protein ; HMGI ; HNF3 ; Humans ; IGFBP-1 ; Insulin-Like Growth Factor Binding Protein 1 - genetics ; IRE ; Leucine Zippers ; liver ; Nuclear Proteins - metabolism ; Promoter Regions, Genetic ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Progress in growth factor research, 1995, Vol.6 (2), p.93-101</ispartof><rights>1996</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-b954e249e5d039aab7da5e63bee270b5440f6e9969e55d09e2e2df374f2f9d493</citedby><cites>FETCH-LOGICAL-c272t-b954e249e5d039aab7da5e63bee270b5440f6e9969e55d09e2e2df374f2f9d493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8817651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Powell, David R.</creatorcontrib><creatorcontrib>Allander, Susanne V.</creatorcontrib><creatorcontrib>Scheimann, Ann O.</creatorcontrib><creatorcontrib>Wasserman, Richard M.</creatorcontrib><creatorcontrib>Durham, Susan K.</creatorcontrib><creatorcontrib>Suwanichkul, Adisak</creatorcontrib><title>Multiple proteins bind the insulin response element in the human IGFBP-1 promoter</title><title>Progress in growth factor research</title><addtitle>Prog Growth Factor Res</addtitle><description>An insulin response element (IRE) has been identified ∼100 base pairs (bp) 5′ to the transcription start site of the human insulin-like growth factor binding protein-1 (hIGFBP-1) gene. This
cis element appears crucial to the multihormonal regulation of hIGFBP-1 expression in liver, since (i) an intact IRE is required for maximal stimulation of hIGFBP-1 promoter activity by dexamethasone, and (ii) the IRE confers activity. Further progress in understanding how the IRE confers insulin and glucocorticoid effects requires identification of transcription factors confering effects of these hormones. D-site binding protein (DBP), and members of the hepatic nuclear factor 3 (HNF 3) and high mobility group I/Y (HMG I/Y) protein families, each known to bind DNA elements similar in sequence to the IRE, were tested for IRE binding. DBP, HMGI and HNF 3β each protected the hIGFBP-1 IRE from DN AseI digestion. Additional studies are required to establish whether binding of any of these proteins to the IRE is important to the regulation of hIGFBP-1 expression by insulin and/or glucocorticoids.</description><subject>DBP</subject><subject>Deoxyribonuclease I - metabolism</subject><subject>DNA - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Hepatocyte Nuclear Factor 3-beta</subject><subject>High Mobility Group Proteins - metabolism</subject><subject>HMGA1a Protein</subject><subject>HMGI</subject><subject>HNF3</subject><subject>Humans</subject><subject>IGFBP-1</subject><subject>Insulin-Like Growth Factor Binding Protein 1 - genetics</subject><subject>IRE</subject><subject>Leucine Zippers</subject><subject>liver</subject><subject>Nuclear Proteins - metabolism</subject><subject>Promoter Regions, Genetic</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0955-2235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LwzAUx3NQ5pz-Bwo9iR6qSZo0zUXQ4eZgooKeQ9u8skib1qQV_O9Nt7Gjp0fe98cjH4QuCL4lmKR3WHIeU5rwa8lvMMYJi7MjND2sT9Cp918YE0E4m6BJlhGRcjJF7y9D3ZuuhqhzbQ_G-qgwVkf9BqLwGGpjIwe-a62HCGpowPZB2OqboclttFouHt9iMuab0ODO0HGV1x7O93OGPhdPH_PneP26XM0f1nFJBe3jQnIGlEngGicyzwuhcw5pUgBQgQvOGK5SkDINjmCRQIHqKhGsopXUTCYzdLXrDYe_B_C9aowvoa5zC-3glRCSUizSYGQ7Y-la7x1UqnOmyd2vIliN9NSISY2YlORqS09lIXa57x-KBvQhtEcX9PudDuGTPwac8qUBW4I2Dspe6db8f-APIiiAVw</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Powell, David R.</creator><creator>Allander, Susanne V.</creator><creator>Scheimann, Ann O.</creator><creator>Wasserman, Richard M.</creator><creator>Durham, Susan K.</creator><creator>Suwanichkul, Adisak</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Multiple proteins bind the insulin response element in the human IGFBP-1 promoter</title><author>Powell, David R. ; Allander, Susanne V. ; Scheimann, Ann O. ; Wasserman, Richard M. ; Durham, Susan K. ; Suwanichkul, Adisak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-b954e249e5d039aab7da5e63bee270b5440f6e9969e55d09e2e2df374f2f9d493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>DBP</topic><topic>Deoxyribonuclease I - metabolism</topic><topic>DNA - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Hepatocyte Nuclear Factor 3-beta</topic><topic>High Mobility Group Proteins - metabolism</topic><topic>HMGA1a Protein</topic><topic>HMGI</topic><topic>HNF3</topic><topic>Humans</topic><topic>IGFBP-1</topic><topic>Insulin-Like Growth Factor Binding Protein 1 - genetics</topic><topic>IRE</topic><topic>Leucine Zippers</topic><topic>liver</topic><topic>Nuclear Proteins - metabolism</topic><topic>Promoter Regions, Genetic</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Powell, David R.</creatorcontrib><creatorcontrib>Allander, Susanne V.</creatorcontrib><creatorcontrib>Scheimann, Ann O.</creatorcontrib><creatorcontrib>Wasserman, Richard M.</creatorcontrib><creatorcontrib>Durham, Susan K.</creatorcontrib><creatorcontrib>Suwanichkul, Adisak</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in growth factor research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Powell, David R.</au><au>Allander, Susanne V.</au><au>Scheimann, Ann O.</au><au>Wasserman, Richard M.</au><au>Durham, Susan K.</au><au>Suwanichkul, Adisak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple proteins bind the insulin response element in the human IGFBP-1 promoter</atitle><jtitle>Progress in growth factor research</jtitle><addtitle>Prog Growth Factor Res</addtitle><date>1995</date><risdate>1995</risdate><volume>6</volume><issue>2</issue><spage>93</spage><epage>101</epage><pages>93-101</pages><issn>0955-2235</issn><abstract>An insulin response element (IRE) has been identified ∼100 base pairs (bp) 5′ to the transcription start site of the human insulin-like growth factor binding protein-1 (hIGFBP-1) gene. This
cis element appears crucial to the multihormonal regulation of hIGFBP-1 expression in liver, since (i) an intact IRE is required for maximal stimulation of hIGFBP-1 promoter activity by dexamethasone, and (ii) the IRE confers activity. Further progress in understanding how the IRE confers insulin and glucocorticoid effects requires identification of transcription factors confering effects of these hormones. D-site binding protein (DBP), and members of the hepatic nuclear factor 3 (HNF 3) and high mobility group I/Y (HMG I/Y) protein families, each known to bind DNA elements similar in sequence to the IRE, were tested for IRE binding. DBP, HMGI and HNF 3β each protected the hIGFBP-1 IRE from DN AseI digestion. Additional studies are required to establish whether binding of any of these proteins to the IRE is important to the regulation of hIGFBP-1 expression by insulin and/or glucocorticoids.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>8817651</pmid><doi>10.1016/0955-2235(95)00034-8</doi><tpages>9</tpages></addata></record> |
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| ispartof | Progress in growth factor research, 1995, Vol.6 (2), p.93-101 |
| issn | 0955-2235 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | DBP Deoxyribonuclease I - metabolism DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Hepatocyte Nuclear Factor 3-beta High Mobility Group Proteins - metabolism HMGA1a Protein HMGI HNF3 Humans IGFBP-1 Insulin-Like Growth Factor Binding Protein 1 - genetics IRE Leucine Zippers liver Nuclear Proteins - metabolism Promoter Regions, Genetic Transcription Factors - genetics Transcription Factors - metabolism |
| title | Multiple proteins bind the insulin response element in the human IGFBP-1 promoter |
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