RefVal: a program implementing the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values
RefVal is a computer program that implements the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. The program performs the following main tasks: graphical display of the distribution of reference values, identification or elimina...
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| Veröffentlicht in: | Computer methods and programs in biomedicine 1995-12, Vol.48 (3), p.247-256 |
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| container_title | Computer methods and programs in biomedicine |
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| creator | Solberg, Helge Erik |
| description | RefVal is a computer program that implements the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. The program performs the following main tasks: graphical display of the distribution of reference values, identification or elimination of outliers, testing of the fit of the distribution to Gaussian shape (coefficients of skewness and kurtosis, Anderson-Darling's test, Cramér-von Mises' test, Kolmogorov-Smirnov's test), non-parametric and parametric estimation of reference limits (fractiles, percentiles). The parametric estimation method is based on a two-stage mathematical transformation of data: (1) Manly's exponential transformation (to remove skewness) and (2) John and Draper's modulus transformation (to adjust for remaining kurtosis). The program exists in different versions. The paper describes two of these: (1) a library of FORTRAN functions and subroutines and (2) a Pascal PC program that runs under MS-DOS. |
| doi_str_mv | 10.1016/0169-2607(95)01697-X |
| format | Article |
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| identifier | ISSN: 0169-2607 |
| ispartof | Computer methods and programs in biomedicine, 1995-12, Vol.48 (3), p.247-256 |
| issn | 0169-2607 1872-7565 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77920612 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Bias Chemistry, Clinical - standards Confidence interval Data Interpretation, Statistical Distribution tests Fractile estimation International Agencies Mathematical transformations Non-parametric method Numerical Analysis, Computer-Assisted Outlier detection Parametric method Programming Languages Reference interval Reference limits Reference Standards Software Validation Statistics, Nonparametric |
| title | RefVal: a program implementing the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values |
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