GABAA Receptors Modulate Early Spontaneous Excitatory Activity in Differentiating P19 Neurons

: P19 embryonic carcinoma (EC) stem cells are pluripotent and are efficiently induced to differentiate into neurons and glia with retinoic acid (RA) treatment. Within 5 days, a substantial number of differentiating P19 cells express gene products that are characteristic of a neuronal phenotype. P19...

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Veröffentlicht in:	Journal of neurochemistry 1996-01, Vol.66 (1), p.233-242
Hauptverfasser:	Lin, Pengxin, Kusano, Kiyoshi, Zhang, Qianlin, Felder, Christian C., Geiger, Peter M., Mahan, Lawrence C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Biological and medical sciences Biomarkers Calcium - physiology Carcinoma, Embryonal - pathology Cell Differentiation - drug effects Cell line Embryonal carcinoma Fundamental and applied biological sciences. Psychology GABA GABAA receptor gamma-Aminobutyric Acid - pharmacology Isolated neuron and nerve. Neuroglia Mice Neuroglia - drug effects Neuroglia - physiology Neuronal differentiation Neurons - drug effects Neurons - physiology PCR Receptors, GABA-A - drug effects Receptors, GABA-A - physiology Stem Cells - drug effects Stem Cells - physiology Tretinoin - pharmacology Tumor Cells, Cultured - drug effects Vertebrates: nervous system and sense organs
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