Reduction in Peripheral Nerve Allograft Antigenicity with Warm and Cold Temperature Preservation
Lymphocyte migration into fresh and preserved peripheral nerve allografts was assessed to determine the effects of preservation lime, preservation temperature, and graft harvest technique on the immunologic response to the peripheral nerve allograft. Peroneal nerve was harvested from either live or...
Gespeichert in:
| Veröffentlicht in: | Plastic and reconstructive surgery (1963) 1996-01, Vol.97 (1), p.152-160 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 160 |
|---|---|
| container_issue | 1 |
| container_start_page | 152 |
| container_title | Plastic and reconstructive surgery (1963) |
| container_volume | 97 |
| creator | Strasberg, Suzanne R Mackinnon, Susan E Hare, Gregory M. T Narini, Philip P Hertl, Catherine M Hay, John B |
| description | Lymphocyte migration into fresh and preserved peripheral nerve allografts was assessed to determine the effects of preservation lime, preservation temperature, and graft harvest technique on the immunologic response to the peripheral nerve allograft. Peroneal nerve was harvested from either live or cadaveric (tissue) donors and stored as 1.5-cm segments at 5°C or 37°C for 1, 3, 5, or 7 days. Each of nine outbred ewes then received multiple segments of peroneal autograft, fresh allograft, and preserved nerve allograft implants. Lymphocyte migration was studied 7 days after implantation by intravenous injection of autologous In-labeled lymphocytes and quantified by gamma counter. Lymphocyte migration into fresh allografts (7212 ± 1575) increased an average of 4.1 times over fresh autograft tissue (1758 ± 421; p < 0.05). Short-term preservation (24 hours) at both temperatures enhanced lymphocyte migration into pretreated allograft tissue (12684 ± 2575 at 5°C, 8751 ± 1577 at 37°C) as compared with fresh allograft (7212 ± 1575). Conversely, 7 days of pretreatment at both 5°C (3586 ± 1421) and 37°C (1570 ± 414) resulted in migration values not significantly different from autograft. No statistically significant difference was seen between grafts harvested from live (5710 ± 1651) versus cadaveric (tissue) donors (4013 ± 832) after 5 days of cold preservation. (Plast. Reconstr. Surg. 97152, 1996.) |
| doi_str_mv | 10.1097/00006534-199601000-00025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77917782</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77917782</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3845-6784c80deb7cf3b7e20266bf6d40a68616da9bfb85dd0ed711ab08c711c984633</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo6-zoTxByEG-95quT9HEYXBUWXWTFY0wn1TvRdPeYpB3235t1xrlZUBRFvW8VPIUQpuSKkk69JTVky0VDu04SWrumJmufoBVtWdcIJthTtCKEs4aSlj1Hlzn_IIQqLtsLdKFbzpTiK_T9C_jFlTBPOEz4FlLY7yDZiD9B-g14E-N8n-xQ8GYq4R6m4EJ5wIdQdvibTSO2k8fbOXp8B-O-GsuSAN8myNVuH9e-QM8GGzO8PNU1-nr97m77obn5_P7jdnPTOK5F20ilhdPEQ6_cwHsFjDAp-0F6QazUkkpvu37odes9Aa8otT3RrlbXaSE5X6M3x737NP9aIBczhuwgRjvBvGSjVEeV0qwK9VHo0pxzgsHsUxhtejCUmEe45h9cc4Zr_sKt1lenG0s_gj8bTzTr_PVpbrOzcUh2ciGfZZxQLuoH1kgcZYc5Fkj5Z1wOkMwObCw787_X8j-JE5Gm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77917782</pqid></control><display><type>article</type><title>Reduction in Peripheral Nerve Allograft Antigenicity with Warm and Cold Temperature Preservation</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Strasberg, Suzanne R ; Mackinnon, Susan E ; Hare, Gregory M. T ; Narini, Philip P ; Hertl, Catherine M ; Hay, John B</creator><creatorcontrib>Strasberg, Suzanne R ; Mackinnon, Susan E ; Hare, Gregory M. T ; Narini, Philip P ; Hertl, Catherine M ; Hay, John B</creatorcontrib><description>Lymphocyte migration into fresh and preserved peripheral nerve allografts was assessed to determine the effects of preservation lime, preservation temperature, and graft harvest technique on the immunologic response to the peripheral nerve allograft. Peroneal nerve was harvested from either live or cadaveric (tissue) donors and stored as 1.5-cm segments at 5°C or 37°C for 1, 3, 5, or 7 days. Each of nine outbred ewes then received multiple segments of peroneal autograft, fresh allograft, and preserved nerve allograft implants. Lymphocyte migration was studied 7 days after implantation by intravenous injection of autologous In-labeled lymphocytes and quantified by gamma counter. Lymphocyte migration into fresh allografts (7212 ± 1575) increased an average of 4.1 times over fresh autograft tissue (1758 ± 421; p < 0.05). Short-term preservation (24 hours) at both temperatures enhanced lymphocyte migration into pretreated allograft tissue (12684 ± 2575 at 5°C, 8751 ± 1577 at 37°C) as compared with fresh allograft (7212 ± 1575). Conversely, 7 days of pretreatment at both 5°C (3586 ± 1421) and 37°C (1570 ± 414) resulted in migration values not significantly different from autograft. No statistically significant difference was seen between grafts harvested from live (5710 ± 1651) versus cadaveric (tissue) donors (4013 ± 832) after 5 days of cold preservation. (Plast. Reconstr. Surg. 97152, 1996.)</description><identifier>ISSN: 0032-1052</identifier><identifier>EISSN: 1529-4242</identifier><identifier>DOI: 10.1097/00006534-199601000-00025</identifier><identifier>PMID: 8532773</identifier><language>eng</language><publisher>Hagerstown, MD: American Society of Plastic Surgeons</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Cell Movement - immunology ; Cranial nerves. Peripheral nerves. Autonomic nervous system ; Erythrocytes - pathology ; Female ; Lymphocytes - immunology ; Medical sciences ; Neurosurgery ; Peripheral Nerves - immunology ; Peripheral Nerves - pathology ; Peripheral Nerves - transplantation ; Peroneal Nerve - immunology ; Peroneal Nerve - pathology ; Peroneal Nerve - transplantation ; Sheep ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Temperature ; Tissue Preservation - methods ; Transplantation, Homologous - immunology ; Transplantation, Homologous - pathology ; Wallerian Degeneration</subject><ispartof>Plastic and reconstructive surgery (1963), 1996-01, Vol.97 (1), p.152-160</ispartof><rights>1996American Society of Plastic Surgeons</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3845-6784c80deb7cf3b7e20266bf6d40a68616da9bfb85dd0ed711ab08c711c984633</citedby><cites>FETCH-LOGICAL-c3845-6784c80deb7cf3b7e20266bf6d40a68616da9bfb85dd0ed711ab08c711c984633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3013417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8532773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strasberg, Suzanne R</creatorcontrib><creatorcontrib>Mackinnon, Susan E</creatorcontrib><creatorcontrib>Hare, Gregory M. T</creatorcontrib><creatorcontrib>Narini, Philip P</creatorcontrib><creatorcontrib>Hertl, Catherine M</creatorcontrib><creatorcontrib>Hay, John B</creatorcontrib><title>Reduction in Peripheral Nerve Allograft Antigenicity with Warm and Cold Temperature Preservation</title><title>Plastic and reconstructive surgery (1963)</title><addtitle>Plast Reconstr Surg</addtitle><description>Lymphocyte migration into fresh and preserved peripheral nerve allografts was assessed to determine the effects of preservation lime, preservation temperature, and graft harvest technique on the immunologic response to the peripheral nerve allograft. Peroneal nerve was harvested from either live or cadaveric (tissue) donors and stored as 1.5-cm segments at 5°C or 37°C for 1, 3, 5, or 7 days. Each of nine outbred ewes then received multiple segments of peroneal autograft, fresh allograft, and preserved nerve allograft implants. Lymphocyte migration was studied 7 days after implantation by intravenous injection of autologous In-labeled lymphocytes and quantified by gamma counter. Lymphocyte migration into fresh allografts (7212 ± 1575) increased an average of 4.1 times over fresh autograft tissue (1758 ± 421; p < 0.05). Short-term preservation (24 hours) at both temperatures enhanced lymphocyte migration into pretreated allograft tissue (12684 ± 2575 at 5°C, 8751 ± 1577 at 37°C) as compared with fresh allograft (7212 ± 1575). Conversely, 7 days of pretreatment at both 5°C (3586 ± 1421) and 37°C (1570 ± 414) resulted in migration values not significantly different from autograft. No statistically significant difference was seen between grafts harvested from live (5710 ± 1651) versus cadaveric (tissue) donors (4013 ± 832) after 5 days of cold preservation. (Plast. Reconstr. Surg. 97152, 1996.)</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Movement - immunology</subject><subject>Cranial nerves. Peripheral nerves. Autonomic nervous system</subject><subject>Erythrocytes - pathology</subject><subject>Female</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Neurosurgery</subject><subject>Peripheral Nerves - immunology</subject><subject>Peripheral Nerves - pathology</subject><subject>Peripheral Nerves - transplantation</subject><subject>Peroneal Nerve - immunology</subject><subject>Peroneal Nerve - pathology</subject><subject>Peroneal Nerve - transplantation</subject><subject>Sheep</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Temperature</subject><subject>Tissue Preservation - methods</subject><subject>Transplantation, Homologous - immunology</subject><subject>Transplantation, Homologous - pathology</subject><subject>Wallerian Degeneration</subject><issn>0032-1052</issn><issn>1529-4242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2LFDEQhoMo6-zoTxByEG-95quT9HEYXBUWXWTFY0wn1TvRdPeYpB3235t1xrlZUBRFvW8VPIUQpuSKkk69JTVky0VDu04SWrumJmufoBVtWdcIJthTtCKEs4aSlj1Hlzn_IIQqLtsLdKFbzpTiK_T9C_jFlTBPOEz4FlLY7yDZiD9B-g14E-N8n-xQ8GYq4R6m4EJ5wIdQdvibTSO2k8fbOXp8B-O-GsuSAN8myNVuH9e-QM8GGzO8PNU1-nr97m77obn5_P7jdnPTOK5F20ilhdPEQ6_cwHsFjDAp-0F6QazUkkpvu37odes9Aa8otT3RrlbXaSE5X6M3x737NP9aIBczhuwgRjvBvGSjVEeV0qwK9VHo0pxzgsHsUxhtejCUmEe45h9cc4Zr_sKt1lenG0s_gj8bTzTr_PVpbrOzcUh2ciGfZZxQLuoH1kgcZYc5Fkj5Z1wOkMwObCw787_X8j-JE5Gm</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>Strasberg, Suzanne R</creator><creator>Mackinnon, Susan E</creator><creator>Hare, Gregory M. T</creator><creator>Narini, Philip P</creator><creator>Hertl, Catherine M</creator><creator>Hay, John B</creator><general>American Society of Plastic Surgeons</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199601</creationdate><title>Reduction in Peripheral Nerve Allograft Antigenicity with Warm and Cold Temperature Preservation</title><author>Strasberg, Suzanne R ; Mackinnon, Susan E ; Hare, Gregory M. T ; Narini, Philip P ; Hertl, Catherine M ; Hay, John B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3845-6784c80deb7cf3b7e20266bf6d40a68616da9bfb85dd0ed711ab08c711c984633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Movement - immunology</topic><topic>Cranial nerves. Peripheral nerves. Autonomic nervous system</topic><topic>Erythrocytes - pathology</topic><topic>Female</topic><topic>Lymphocytes - immunology</topic><topic>Medical sciences</topic><topic>Neurosurgery</topic><topic>Peripheral Nerves - immunology</topic><topic>Peripheral Nerves - pathology</topic><topic>Peripheral Nerves - transplantation</topic><topic>Peroneal Nerve - immunology</topic><topic>Peroneal Nerve - pathology</topic><topic>Peroneal Nerve - transplantation</topic><topic>Sheep</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Temperature</topic><topic>Tissue Preservation - methods</topic><topic>Transplantation, Homologous - immunology</topic><topic>Transplantation, Homologous - pathology</topic><topic>Wallerian Degeneration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strasberg, Suzanne R</creatorcontrib><creatorcontrib>Mackinnon, Susan E</creatorcontrib><creatorcontrib>Hare, Gregory M. T</creatorcontrib><creatorcontrib>Narini, Philip P</creatorcontrib><creatorcontrib>Hertl, Catherine M</creatorcontrib><creatorcontrib>Hay, John B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Plastic and reconstructive surgery (1963)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strasberg, Suzanne R</au><au>Mackinnon, Susan E</au><au>Hare, Gregory M. T</au><au>Narini, Philip P</au><au>Hertl, Catherine M</au><au>Hay, John B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction in Peripheral Nerve Allograft Antigenicity with Warm and Cold Temperature Preservation</atitle><jtitle>Plastic and reconstructive surgery (1963)</jtitle><addtitle>Plast Reconstr Surg</addtitle><date>1996-01</date><risdate>1996</risdate><volume>97</volume><issue>1</issue><spage>152</spage><epage>160</epage><pages>152-160</pages><issn>0032-1052</issn><eissn>1529-4242</eissn><abstract>Lymphocyte migration into fresh and preserved peripheral nerve allografts was assessed to determine the effects of preservation lime, preservation temperature, and graft harvest technique on the immunologic response to the peripheral nerve allograft. Peroneal nerve was harvested from either live or cadaveric (tissue) donors and stored as 1.5-cm segments at 5°C or 37°C for 1, 3, 5, or 7 days. Each of nine outbred ewes then received multiple segments of peroneal autograft, fresh allograft, and preserved nerve allograft implants. Lymphocyte migration was studied 7 days after implantation by intravenous injection of autologous In-labeled lymphocytes and quantified by gamma counter. Lymphocyte migration into fresh allografts (7212 ± 1575) increased an average of 4.1 times over fresh autograft tissue (1758 ± 421; p < 0.05). Short-term preservation (24 hours) at both temperatures enhanced lymphocyte migration into pretreated allograft tissue (12684 ± 2575 at 5°C, 8751 ± 1577 at 37°C) as compared with fresh allograft (7212 ± 1575). Conversely, 7 days of pretreatment at both 5°C (3586 ± 1421) and 37°C (1570 ± 414) resulted in migration values not significantly different from autograft. No statistically significant difference was seen between grafts harvested from live (5710 ± 1651) versus cadaveric (tissue) donors (4013 ± 832) after 5 days of cold preservation. (Plast. Reconstr. Surg. 97152, 1996.)</abstract><cop>Hagerstown, MD</cop><pub>American Society of Plastic Surgeons</pub><pmid>8532773</pmid><doi>10.1097/00006534-199601000-00025</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0032-1052 |
| ispartof | Plastic and reconstructive surgery (1963), 1996-01, Vol.97 (1), p.152-160 |
| issn | 0032-1052 1529-4242 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77917782 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Analysis of Variance Animals Biological and medical sciences Cell Movement - immunology Cranial nerves. Peripheral nerves. Autonomic nervous system Erythrocytes - pathology Female Lymphocytes - immunology Medical sciences Neurosurgery Peripheral Nerves - immunology Peripheral Nerves - pathology Peripheral Nerves - transplantation Peroneal Nerve - immunology Peroneal Nerve - pathology Peroneal Nerve - transplantation Sheep Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Temperature Tissue Preservation - methods Transplantation, Homologous - immunology Transplantation, Homologous - pathology Wallerian Degeneration |
| title | Reduction in Peripheral Nerve Allograft Antigenicity with Warm and Cold Temperature Preservation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T01%3A57%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduction%20in%20Peripheral%20Nerve%20Allograft%20Antigenicity%20with%20Warm%20and%20Cold%20Temperature%20Preservation&rft.jtitle=Plastic%20and%20reconstructive%20surgery%20(1963)&rft.au=Strasberg,%20Suzanne%20R&rft.date=1996-01&rft.volume=97&rft.issue=1&rft.spage=152&rft.epage=160&rft.pages=152-160&rft.issn=0032-1052&rft.eissn=1529-4242&rft_id=info:doi/10.1097/00006534-199601000-00025&rft_dat=%3Cproquest_cross%3E77917782%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77917782&rft_id=info:pmid/8532773&rfr_iscdi=true |