A streptothricin-like antibiotic mixture, A-269A (and A-269A')
A streptothricin-like antibiotic, A-269A (referred to as A-269A hereafter) was isolated from the culture broth of Streptomyces sp., strain No. A-269. In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269A ar...
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| Veröffentlicht in: | Journal of antibiotics 1987, Vol.40 (12), p.1698-1706 |
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| container_issue | 12 |
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| container_title | Journal of antibiotics |
| container_volume | 40 |
| creator | KIDO, Y FURUIE, T SUZUKI, K SAKAMOTO, K YOKOHAMA, Y UYEDA, M KINJYO, J YAHARA, S NOHARA, T SHIBATA, M |
| description | A streptothricin-like antibiotic, A-269A (referred to as A-269A hereafter) was isolated from the culture broth of Streptomyces sp., strain No. A-269. In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269A are reported. The structure of the antibiotic was also examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. From the spectroscopic data, A-269A was assumed to be a mixture of antibiotic LL-BL 136 and an isomeric compound in which the carbamoyl group is substituted on C-12' hydroxyl instead of C-10 hydroxyl. |
| doi_str_mv | 10.7164/antibiotics.40.1698 |
| format | Article |
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In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269A are reported. The structure of the antibiotic was also examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. From the spectroscopic data, A-269A was assumed to be a mixture of antibiotic LL-BL 136 and an isomeric compound in which the carbamoyl group is substituted on C-12' hydroxyl instead of C-10 hydroxyl.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.40.1698</identifier><identifier>PMID: 2828297</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: Japan Antibiotics Research Association</publisher><subject>Aminoglycosides ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Applied sciences ; Biological and medical sciences ; Biotechnology ; Chemical Phenomena ; Chemistry, Physical ; Exact sciences and technology ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Gas Chromatography-Mass Spectrometry ; Health. Pharmaceutical industry ; Industrial applications and implications. Economical aspects ; Isomerism ; Magnetic Resonance Spectroscopy ; Medical sciences ; Microbial Sensitivity Tests ; Other techniques and industries ; Pharmacology. Drug treatments ; Production of active biomolecules ; Soil Microbiology ; Spectrophotometry, Infrared ; Streptomyces ; Streptomyces - analysis ; streptothricin ; Streptothricins - isolation & purification ; Streptothricins - pharmacology</subject><ispartof>Journal of antibiotics, 1987, Vol.40 (12), p.1698-1706</ispartof><rights>1989 INIST-CNRS</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c637t-5e1988ad34ad6708afe9deb1c9c992cce169b9cb2f4cda2870b7bc7bbe5497dc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7073519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7484309$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2828297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIDO, Y</creatorcontrib><creatorcontrib>FURUIE, T</creatorcontrib><creatorcontrib>SUZUKI, K</creatorcontrib><creatorcontrib>SAKAMOTO, K</creatorcontrib><creatorcontrib>YOKOHAMA, Y</creatorcontrib><creatorcontrib>UYEDA, M</creatorcontrib><creatorcontrib>KINJYO, J</creatorcontrib><creatorcontrib>YAHARA, S</creatorcontrib><creatorcontrib>NOHARA, T</creatorcontrib><creatorcontrib>SHIBATA, M</creatorcontrib><title>A streptothricin-like antibiotic mixture, A-269A (and A-269A')</title><title>Journal of antibiotics</title><addtitle>J Antibiot (Tokyo)</addtitle><description>A streptothricin-like antibiotic, A-269A (referred to as A-269A hereafter) was isolated from the culture broth of Streptomyces sp., strain No. A-269. In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269A are reported. The structure of the antibiotic was also examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. From the spectroscopic data, A-269A was assumed to be a mixture of antibiotic LL-BL 136 and an isomeric compound in which the carbamoyl group is substituted on C-12' hydroxyl instead of C-10 hydroxyl.</description><subject>Aminoglycosides</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Exact sciences and technology</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Health. Pharmaceutical industry</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Isomerism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Other techniques and industries</subject><subject>Pharmacology. Drug treatments</subject><subject>Production of active biomolecules</subject><subject>Soil Microbiology</subject><subject>Spectrophotometry, Infrared</subject><subject>Streptomyces</subject><subject>Streptomyces - analysis</subject><subject>streptothricin</subject><subject>Streptothricins - isolation & purification</subject><subject>Streptothricins - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMo4zj6BCJ0IV7A1qTJ5LIRyuANBtzoOiRpitFexiQFfXs7TBndDVmcwPnOzzkfAKcIZgxRcqva6LTrojMhIzBDVPA9MEWcoxQRKvbBFMIcpZzn8BAchfABIWaY8QmY5Hx4gk3BXZGE6O0qdvHdO-PatHafNvmLThr3HXtvb5IizakokivVluP_8voYHFSqDvZkrDPw9nD_unhKly-Pz4timRqKWUznFgnOVYmJKimDXFVWlFYjI4wQuTF22F0Lo_OKmFLlnEHNtGFa2zkRrDR4Bi42uSvfffU2RNm4YGxdq9Z2fZCMCUTpcN8uEBFB0CBhAPEGNL4LwdtKrrxrlP-RCMq1XvlPryRQrvUOU2djfK8bW25nRp9D_3zsq2BUXXnVGhe2GCOcYCh2YpDhORL4F4eYkM8</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>KIDO, Y</creator><creator>FURUIE, T</creator><creator>SUZUKI, K</creator><creator>SAKAMOTO, K</creator><creator>YOKOHAMA, Y</creator><creator>UYEDA, M</creator><creator>KINJYO, J</creator><creator>YAHARA, S</creator><creator>NOHARA, T</creator><creator>SHIBATA, M</creator><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>A streptothricin-like antibiotic mixture, A-269A (and A-269A')</title><author>KIDO, Y ; FURUIE, T ; SUZUKI, K ; SAKAMOTO, K ; YOKOHAMA, Y ; UYEDA, M ; KINJYO, J ; YAHARA, S ; NOHARA, T ; SHIBATA, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c637t-5e1988ad34ad6708afe9deb1c9c992cce169b9cb2f4cda2870b7bc7bbe5497dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aminoglycosides</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Exact sciences and technology</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Health. Pharmaceutical industry</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Isomerism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Other techniques and industries</topic><topic>Pharmacology. Drug treatments</topic><topic>Production of active biomolecules</topic><topic>Soil Microbiology</topic><topic>Spectrophotometry, Infrared</topic><topic>Streptomyces</topic><topic>Streptomyces - analysis</topic><topic>streptothricin</topic><topic>Streptothricins - isolation & purification</topic><topic>Streptothricins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIDO, Y</creatorcontrib><creatorcontrib>FURUIE, T</creatorcontrib><creatorcontrib>SUZUKI, K</creatorcontrib><creatorcontrib>SAKAMOTO, K</creatorcontrib><creatorcontrib>YOKOHAMA, Y</creatorcontrib><creatorcontrib>UYEDA, M</creatorcontrib><creatorcontrib>KINJYO, J</creatorcontrib><creatorcontrib>YAHARA, S</creatorcontrib><creatorcontrib>NOHARA, T</creatorcontrib><creatorcontrib>SHIBATA, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIDO, Y</au><au>FURUIE, T</au><au>SUZUKI, K</au><au>SAKAMOTO, K</au><au>YOKOHAMA, Y</au><au>UYEDA, M</au><au>KINJYO, J</au><au>YAHARA, S</au><au>NOHARA, T</au><au>SHIBATA, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A streptothricin-like antibiotic mixture, A-269A (and A-269A')</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J Antibiot (Tokyo)</addtitle><date>1987</date><risdate>1987</risdate><volume>40</volume><issue>12</issue><spage>1698</spage><epage>1706</epage><pages>1698-1706</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>A streptothricin-like antibiotic, A-269A (referred to as A-269A hereafter) was isolated from the culture broth of Streptomyces sp., strain No. A-269. In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269A are reported. The structure of the antibiotic was also examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. From the spectroscopic data, A-269A was assumed to be a mixture of antibiotic LL-BL 136 and an isomeric compound in which the carbamoyl group is substituted on C-12' hydroxyl instead of C-10 hydroxyl.</abstract><cop>Tokyo</cop><pub>Japan Antibiotics Research Association</pub><pmid>2828297</pmid><doi>10.7164/antibiotics.40.1698</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of antibiotics, 1987, Vol.40 (12), p.1698-1706 |
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| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Aminoglycosides Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Applied sciences Biological and medical sciences Biotechnology Chemical Phenomena Chemistry, Physical Exact sciences and technology Fermentation Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Isomerism Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Other techniques and industries Pharmacology. Drug treatments Production of active biomolecules Soil Microbiology Spectrophotometry, Infrared Streptomyces Streptomyces - analysis streptothricin Streptothricins - isolation & purification Streptothricins - pharmacology |
| title | A streptothricin-like antibiotic mixture, A-269A (and A-269A') |
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