Isolation, characterization, and partial purification of a novel ubiquitin-protein ligase, E3. Targeting of protein substrates via multiple and distinct recognition signals and conjugating enzymes

Degradation of a protein via the ubiquitin system involves two discrete steps, conjugation of ubiquitin to the substrate and degradation of the adduct. Conjugation follows a three-step mechanism. First, ubiquitin is activated by the ubiquitin-activating enzyme, E1. Following activation, one of sever...

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Veröffentlicht in:	The Journal of biological chemistry 1996-01, Vol.271 (1), p.302-310
Hauptverfasser:	Gonen, H, Stancovski, I, Shkedy, D, Hadari, T, Bercovich, B, Bengal, E, Mesilati, S, Abu-Hatoum, O, Schwartz, A L, Ciechanover, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Hydrolysis Ligases - isolation & purification Ligases - metabolism Muramidase - metabolism Protein Sorting Signals - metabolism Rabbits Ribonuclease, Pancreatic - metabolism Substrate Specificity Ubiquitin-Activating Enzymes Ubiquitin-Protein Ligases
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